当前位置： SCI文献检索 > CHEMOTHERAPY期刊下所有文献 > Anti-cachectic effect of clarithromycin for patients with unresectable non-small cell lung cancer.

Anti-cachectic effect of clarithromycin for patients with unresectable non-small cell lung cancer.

Abstract：

:We have previously reported that long-term treatment with clarithromycin (CAM) increased the median survival of patients with non-small cell lung cancer, and improved various clinical parameters in these patients. In the present study, CAM was administered to 33 patients with unresectable primary non-small cell lung cancer, who had received chemotherapy, radiotherapy or both (basic cancer therapy). Patients with clinical backgrounds matched to the CAM group, who did not receive CAM treatment, were included into this study as a control group (non-CAM group). CAM treatment was initiated 4 weeks after the basic cancer therapy. The non-CAM group did not receive a placebo. Before and after the 3-month treatment with CAM, body weight, serum levels of interleukin-6 (IL-6, a cytokine which, together with TNF-alpha, plays a crucial role in the development of cancer cachexia), total protein, albumin, cholinesterase and hemoglobin were measured for the evaluation of the patients' clinical status. There were no statistically significant differences in serum levels of IL-6 between the CAM group before the treatment and the non-CAM group. After 3 months of CAM treatment, serum levels of IL-6 significantly decreased. In contrast, body weight, cholinesterase, and hemoglobin increased to a significant extent. Among these four parameters, however, the decrease in serum IL-6 levels was only statistically correlated with the increase in body weight, but not with that in other parameters. Furthermore, CAM-treated patients whose serum IL-6 levels were decreased after 3 months of treatment survived longer: there was a statistically significant correlation between the decrease in serum IL-6 and survival time. In contrast, in the non-CAM group, these parameters did not change significantly during the study. These results suggest that CAM may reduce the progression of cancer-associated cachexia.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Sakamoto M,Mikasa K,Majima T,Hamada K,Konishi M,Maeda K,Kita E,Narita N

doi

10.1159/000048556

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

444-51

issue

eissn

0009-3157

issn

1421-9794

pii

che47444

journal_volume

pub_type

临床试验,杂志文章

在线工具

Anti-cachectic effect of clarithromycin for patients with unresectable non-small cell lung cancer.