Antiandrogen and antineoplastic effects of a novel drug, CPC10997.

abstract：:A total of 5 healthy volunteers were enrolled in a crossover study on the dose dependency and the effect of probenecid on pharmacokinetics of DQ-2556. They were administered intravenously 0.5 and 1.0 g of DQ-2556, and 1.0 g of DQ-2556 with oral administration of probenecid. The linearity in pharmacokinetics of DQ-2556...

journal_title：Chemotherapy

authors： Shiba K,Yoshida M,Shimada J,Saito A,Matsubayashi K,Hashimoto S,Yoshida K,Osada Y,Sakai O

更新日期：1992-01-01 00:00:00

abstract：:The effect of deficiency of vitamin A and its supplementation on growth of murine sarcoma 180 was evaluated. The efficacy of cyclophosphamide under depleted and supplemented condition of the vitamin was also scrutinized. Supplemental vitamin A helped to check progression of tumour growth and also increased the effecti...

journal_title：Chemotherapy

authors： Ghosh J,Das S

更新日期：1987-01-01 00:00:00

abstract：:Oxygen radical generation by blood cells before and after chemotherapy was investigated in 16 elderly (72.8 +/- 1.0 years) and 14 adult (45.0 +/- 2.4 years) patients with lung cancer, using a lucigenin-dependent chemiluminescence method. The oxygen radical generation by 100 microliters of blood before chemotherapy in ...

journal_title：Chemotherapy

authors： Teramoto S,Fukuchi Y,Shu CY,Orimo H

更新日期：1995-05-01 00:00:00

abstract：:Within recent years, novel serological and molecular methods have been developed to improve the early diagnosis of invasive fungal infections especially in patients with malignant hematological diseases being at highest risk of developing these life-threatening infections. Early diagnosis is essential for adequate the...

journal_title：Chemotherapy

authors： Buchheidt D,Skladny H,Baust C,Hehlmann R

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00

abstract：:Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...

journal_title：Chemotherapy

authors： Yamabe S

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...

journal_title：Chemotherapy

authors： El Malki HO,Mohsine R,Benkhraba K,Amahzoune M,Benkabbou A,El Absi M,Ifrine L,Belkouchi A,Balafrej S

更新日期：2006-01-01 00:00:00

abstract：:We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amika...

journal_title：Chemotherapy

authors： Jacobson K,Rolston K,Elting L,LeBlanc B,Whimbey E,Ho DH

更新日期：1999-09-01 00:00:00

abstract：:Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...

journal_title：Chemotherapy

authors： Llorens J,Ley G,Forés A,Olay T

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00

abstract：:A semi-automated microdilution test was adapted for the in vitro testing of potential antitrichomonal agents. Washed cell suspensions of the pathogenic protozoan Trichomonas vaginalis were incubated in microtitration plates for 4 h at 37 degrees C in the presence radiolabelled adenine and serial dilutions of the test ...

journal_title：Chemotherapy

authors： Meingassner JG,Heyworth PG,Havelec L

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:In this study, the in vitro antimicrobial activity and spectrum of new dimeric compounds derived from the cyanobacterial alkaloid nostocarboline were investigated. The mechanism of action and selectivity to bacteria were studied and compared to the cationic antiseptic chlorhexidine. METHODS:Minimal inhibito...

journal_title：Chemotherapy

authors： Locher HH,Ritz D,Pfaff P,Gaertner M,Knezevic A,Sabato D,Schroeder S,Barbaras D,Gademann K

更新日期：2010-01-01 00:00:00

abstract：:A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...

journal_title：Chemotherapy

authors： Kissling M,Bergamini N

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...

journal_title：Chemotherapy

authors： Kim SH,Jeong SH,Kim JW,Lee SH,Kim JM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIM:A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and ...

journal_title：Chemotherapy

authors： Nagase H,Nakagawa F,Uchida J

更新日期：2018-01-01 00:00:00

abstract：:New fluoroquinolones, as exemplified by levofloxacin, possess broad spectrum activity against many common pathogens, including the majority responsible for respiratory tract infections (RTIs), atypical pathogens and those resistant to other therapeutic regimens. Following administration, levofloxacin attains high intr...

journal_title：Chemotherapy

authors： Graninger W,Zeitlinger M

更新日期：2004-01-01 00:00:00

abstract：:Many bis(amidinohydrazones) are potent inhibitors of adenosylmethionine decarboxylase (AdoMetDC), a key enzyme of polyamine biosynthesis, and some of them are also known to be powerful antiviral agents. Therefore, seven bis(amidinohydrazones), including the two most potent inhibitors of eukaryotic AdoMetDC so far repo...

journal_title：Chemotherapy

authors： Elo H

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...

journal_title：Chemotherapy

authors： Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

更新日期：2004-06-01 00:00:00

abstract：:17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...

journal_title：Chemotherapy

authors： Focht J,Klietmann W,Nösner K,Rolinson GN,Johnsen J

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：:Gametocytocidal activity of artemisinin (qinghaosu) has been demonstrated against simian malaria parasite Plasmodium cynomolgi B. Colony-bred Anopheles stephensi were allowed to feed on gametocyte-carrying rhesus monkeys and the mosquito infectivity rate and oocyst count of the infected mosquito gut were recorded on d...

journal_title：Chemotherapy

authors： Dutta GP,Bajpai R,Vishwakarma RA

更新日期：1989-01-01 00:00:00

abstract：:Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...

journal_title：Chemotherapy

authors： Denning DW,Donnelly JP,Hellreigel KP,Ito J,Martino P,van't Wout JW

更新日期：1992-01-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:Minimal bactericidal concentrations of thienamycin revealed moderate intraphagolysosomal bactericidal activity against pseudo-(PSR) and genuinely serum-resistant (NSS) assay strains of Serratia marcescens. Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blo...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1983-01-01 00:00:00

abstract：:Antimicrobial agents may interact with polymorphonuclear leukocytes and directly modify the leukocyte functions, or bacteria can be modified by the antimicrobial agents causing them to be treated differently by phagocytic cells. Brief exposure of bacteria to high levels of antimicrobials can affect their interaction w...

journal_title：Chemotherapy

authors： Pérez P,Herrera I,Martín M,Martínez P,Gómez-Lus ML

更新日期：1994-03-01 00:00:00

abstract：:There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, daunorubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this s...

journal_title：Chemotherapy

authors： Look MP,Musch E

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The aim of this clinical study was to evaluate the efficacy of combination chemotherapy of oxaliplatin, leucovorin and continuous-infusion 5-fluorouracil (5-FU) for advanced gastric cancer. METHODS:Patients with previously untreated gastric cancer with measurable disease received oxaliplatin (100 mg/m(2), d...

journal_title：Chemotherapy

authors： Lim JY,Cho JY,Oh KJ,Choi SH,Lee SI,Jeung HC

更新日期：2009-01-01 00:00:00

abstract：:Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...

journal_title：Chemotherapy

authors： Ferraro G,Ambrosi G,Bucci L,Palmieri R,Palmieri G

更新日期：1990-01-01 00:00:00

abstract：:The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...

journal_title：Chemotherapy

authors： Alrifai T,Grant Szymanski K,Venugopal P,Mahon B,Okwuosa T,Karmali R

更新日期：2017-01-01 00:00:00

abstract：:Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...

journal_title：Chemotherapy

authors： Hof H,Müller KM,Heine WD

更新日期：1982-01-01 00:00:00