Abstract:
:The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincristine), and prednisone (R-CHOP). The use of the anthracycline doxorubicin has been associated with arrhythmias and cardiomyopathy, making patients with cardiac dysfunction poor candidates for R-CHOP. As such, it is imperative to find alternative regimens that omit cardiac toxicity without compromising efficacy for this patient population. We report a case of composite NHL in a patient who received frontline bendamustine with rituximab with encouraging results. Our patient had a left ventricular ejection fraction of 20%, making her a poor candidate for anthracycline-based therapy. We opted to administer bendamustine with rituximab for a total of 6 cycles. She remains disease free 18 months after the completion of therapy.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Alrifai T,Grant Szymanski K,Venugopal P,Mahon B,Okwuosa T,Karmali Rdoi
10.1159/000452756subject
Has Abstractpub_date
2017-01-01 00:00:00pages
140-146issue
2eissn
0009-3157issn
1421-9794pii
000452756journal_volume
62pub_type
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