Single-Agent Pixantrone as a Bridge to Autologous Stem Cell Transplantation in a Patient with Refractory Diffuse Large B-Cell Lymphoma.

abstract：:A single oral dose of an antimicrobial agent is as effective as a conventional 3-day course for the treatment of uncomplicated lower urinary tract infections. A case history of a young woman with recurrent cystitis is presented to demonstrate this approach to the management of a common clinical problem. The place of a...

journal_title：Chemotherapy

authors： Bailey RR

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...

journal_title：Chemotherapy

authors： Kodama T,Watanabe K,Shinkai M,Kaneko T

更新日期：2018-01-01 00:00:00

abstract：:Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not lik...

journal_title：Chemotherapy

authors： Ericsson CD,DuPont HL

更新日期：2005-01-01 00:00:00

abstract：:The involvement of plasma testosterone in patients associated with scalp hair loss accelerated by anticancer drugs including aclarubicin and cisplatin was investigated. Scalp hair loss observed was minor in 12 and severe in 2 out of 31 patients. In patients without significant hair loss, the combination of aclarubicin...

journal_title：Chemotherapy

authors： Umeki S,Niki Y,Soejima R

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pili that help them bind to specific tissue receptors. One such adhesin is Dr, which binds ...

journal_title：Chemotherapy

authors： Kachroo BB

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...

journal_title：Chemotherapy

authors： Cirino IC,Menezes-Silva SM,Silva HT,de Souza EL,Siqueira-Júnior JP

更新日期：2014-01-01 00:00:00

abstract：:We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6-10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10-14 days and therapeutical succ...

journal_title：Chemotherapy

authors： Lus RG,Calvo MC,Lopez LG,Cancer RC,Molina AM,Sanchez ED,Parilla AC,Mur LL

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND/AIMS:A single-institution phase I trial to determine the feasibility of using filgrastim or pegfilgrastim to increase the dose intensity of biweekly docetaxel and gemcitabine. METHODS:Patients with metastatic solid tumors received gemcitabine 3,000 mg/m(2) and increasing doses of docetaxel (55 mg/m(2) in 10...

journal_title：Chemotherapy

authors： Dragnev KH,Hardin SB,Pipas JM,Davis TH,Rigas JR

更新日期：2010-01-01 00:00:00

abstract：:The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37 degrees C) of PMN with different concentrations of linezolid (2, 10 and 20 mg/l) did not significantly affect the phagocytosis of either...

journal_title：Chemotherapy

authors： Ballesta S,Pascual A,García I,Perea EJ

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Enterococci and especially glycopeptide-resistant strains (GRE) are widely distributed in the hospital environment, by acquiring resistance determinants and virulence factors. METHODS:The study included 48 GRE isolated during a 1-year period from different inpatients in a tertiary hospital in southwestern G...

journal_title：Chemotherapy

authors： Kolonitsiou F,Mani V,Parikou H,Trakala M,Dimitracopoulos G,Spiliopoulou I

更新日期：2004-11-01 00:00:00

abstract：:Ciprofloxacin (CIP) and metabolite concentrations in lung tissue, parietal pleura and bronchial tissue were assessed in 43 adult patients who underwent lung surgery. A single oral dose of CIP was given for prophylaxis of bacterial infections. Two to 6 h prior to tissues sampling, 23 patients received 250 mg and 20 sub...

journal_title：Chemotherapy

authors： Rohwedder R,Bergan T,Caruso E,Thorsteinsson SB,Della Torre H,Scholl H

更新日期：1991-01-01 00:00:00

abstract：:There is evidence that a variety of anticancer drugs exert their cytotoxic activity by a free-radical-mediated mechanism. These drugs include anthracyclines such as adriamycin, daunorubicin, 4-epi-adriblastin as well as bleomycin, procarbazine, vincristin, cyclophosphamide, etoposide and mitomycin C. The aim of this s...

journal_title：Chemotherapy

authors： Look MP,Musch E

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...

journal_title：Chemotherapy

authors： Benoit-Vical F,Grellier P,Abdoulaye A,Moussa I,Ousmane A,Berry A,Ikhiri K,Poupat C

更新日期：2006-01-01 00:00:00

abstract：:A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...

journal_title：Chemotherapy

authors： Tsai YH,Williams EB,Hirth RS,Price KE

更新日期：1975-01-01 00:00:00

abstract：:Among third-generation cephalosporins, cefodizime (CFDZ) has shown to modulate many functions of the host defense system against infections. The aim of the present study was to assess the in vitro CFDZ-dependent modulation of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-8 release from lipopolysac...

journal_title：Chemotherapy

authors： Meloni F,Ballabio P,Bianchi L,Grassi FA,Gialdroni Grassi GG

更新日期：1995-07-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...

journal_title：Chemotherapy

authors： Mese H,Sasaki A,Alcalde RE,Nakayama S,Matsumura T

更新日期：2000-01-01 00:00:00

abstract：:The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative ba...

journal_title：Chemotherapy

authors： Renzini G,Ravagnan G,Oliva B

更新日期：1975-01-01 00:00:00

abstract：:Chloramphenicol serum concentration is often monitored to assure efficacy and prevent toxicity. We studied the relationship between steady-state chloramphenicol serum concentration and hematologic adverse effects in 45 pediatric patients. The mean peak serum concentration of chloramphenicol in patients with and withou...

journal_title：Chemotherapy

authors： Nahata MC

更新日期：1987-01-01 00:00:00

abstract：:The effect of three nucleoside analogs, including 2-methyl-2'-deoxyadenosine (MDA), 5-amino-2'-deoxyuridine (ADU) and 2',3'-dideoxycytidine (DDC) on colony formation from unfractionated human bone marrow obtained from volunteers expressing parameters typical for normal cells (NBM) and from patients with the diagnosis ...

journal_title：Chemotherapy

authors： Cinatl J Jr,Cinatl J,Gussetis ES,Nemeth U,Mainke M,Kornhuber B,Brendel M,Doerr HW

更新日期：1991-01-01 00:00:00

abstract：:The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...

journal_title：Chemotherapy

authors： Alrifai T,Grant Szymanski K,Venugopal P,Mahon B,Okwuosa T,Karmali R

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatib...

journal_title：Chemotherapy

authors： Draenert ME,Hickel R,Draenert Y

更新日期：2013-01-01 00:00:00

abstract：:Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...

journal_title：Chemotherapy

authors： Hori K

更新日期：2005-10-01 00:00:00

abstract：:The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin. Synergistic antibacterial action (defined as FIC index less than or equal to 0.5) w...

journal_title：Chemotherapy

authors： Kern W,Gulden H,Vanek E,Kurrle E

更新日期：1988-01-01 00:00:00

abstract：:The sensitivity of 23 isolates of opportunistic fungi, Aspergillus fumigatus (5), A. flavus (5), A. niger (5), Pseudallescheria boydii (5), Alternaria alternata (2) and Xylohypha bantiana (1), was investigated against fluconazole and itraconazole, using Sabouraud's dextrose broth (SD) and a high-resolution (HR) medium...

journal_title：Chemotherapy

authors： Sekhon AS,Padhye AA,Garg AK,Hamir Z

更新日期：1992-01-01 00:00:00

abstract：:Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...

journal_title：Chemotherapy

authors： Seydel JK,Wempe E

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...

journal_title：Chemotherapy

authors： Yamamura J,Masuda N,Yamamoto D,Tsuyuki S,Yamaguchi M,Tanaka S,Tsurutani J,Tokunaga S,Yoshidome K,Mizutani M,Aono T,Ooe A,Tanino H,Matsunami N,Yasojima H,Nakayama T,Nishida Y

更新日期：2017-01-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：:The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a d...

journal_title：Chemotherapy

authors： Ikeda F,Yokota Y,Ikemoto A,Teratani N,Shimomura K,Kanno H

更新日期：1995-05-01 00:00:00

abstract：:The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...

journal_title：Chemotherapy

authors： Pusztai-Markos Z,Pranada F,Leimbrock C

更新日期：1982-01-01 00:00:00