The Essential Oil from Origanum vulgare L. and Its Individual Constituents Carvacrol and Thymol Enhance the Effect of Tetracycline against Staphylococcus aureus.

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：:Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...

journal_title：Chemotherapy

authors： Seydel JK,Wempe E

更新日期：1980-01-01 00:00:00

abstract：:The in vitro activity of the new semisynthetic ureidopenicillins azlocillin (AZ) and mezlocillin (MZ), and of the new cephalosporin cefsulodin (CEF) were determined against 50 carbenicillin-sensitive (CARs) and 50 carbenicillin-resistant (CARr) P. aeruginosa clinical isolates. In the CARs group the most active antibio...

journal_title：Chemotherapy

authors： Perea EJ,Palomares JC,García-Iglesias MC

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...

journal_title：Chemotherapy

authors： Guiral E,Bosch J,Vila J,Soto SM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the impact of different temperatures (22, 35 and 37 degrees C) on the postantifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 x MIC) on Candida albicans and Candida glabrata in PAFE stage (PAFSE). METHODS:This stage was induced by a 1.5-hour ...

journal_title：Chemotherapy

authors： García MT,Llorente MT,Mínguez F,Prieto J

更新日期：2000-07-01 00:00:00

abstract：:The in vitro activity of sparfloxacin, a new fluoroquinolone, was compared with ciprofloxacin and ofloxacin against 166 consecutive isolates from the upper respiratory tract of outpatients. The strains were fully susceptible to three quinolones. The antibacterial activity of sparfloxacin was comparable or better than ...

journal_title：Chemotherapy

authors： Malmborg AS,Ahlén S

更新日期：1993-01-01 00:00:00

abstract：:Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...

journal_title：Chemotherapy

authors： Denning DW,Donnelly JP,Hellreigel KP,Ito J,Martino P,van't Wout JW

更新日期：1992-01-01 00:00:00

abstract：:Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromato...

journal_title：Chemotherapy

authors： Viitanen J,Auvinen O,Tunturi T

更新日期：1983-01-01 00:00:00

abstract：:Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....

journal_title：Chemotherapy

authors： Cheng V,Rawlins M,Chang T,Fox E,Dyer J,Allen C,Litton E,Page MM,Hoad K,Roberts JA

更新日期：2019-01-01 00:00:00

abstract：:Among third-generation cephalosporins, cefodizime (CFDZ) has shown to modulate many functions of the host defense system against infections. The aim of the present study was to assess the in vitro CFDZ-dependent modulation of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-8 release from lipopolysac...

journal_title：Chemotherapy

authors： Meloni F,Ballabio P,Bianchi L,Grassi FA,Gialdroni Grassi GG

更新日期：1995-07-01 00:00:00

abstract：:Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not lik...

journal_title：Chemotherapy

authors： Ericsson CD,DuPont HL

更新日期：2005-01-01 00:00:00

abstract：:The minimum inhibitory concentration (MIC) of the new penem ALP 201 was tested against 243 recent clinical isolates of which 95 were from the family Enterobacteriaceae, 50 were from the genus Streptococcus, 50 were Staphylococcus aureus and 48 were Staphylococcus epidermidis. An agar dilution technique was used to det...

journal_title：Chemotherapy

authors： Bergan T,da Fonseca J

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring s...

journal_title：Chemotherapy

authors： Wittau M,Scheele J,Bulitta JB,Mayer B,Kaever V,Burhenne H,Henne-Bruns D,Isenmann R,Brockschmidt C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pili that help them bind to specific tissue receptors. One such adhesin is Dr, which binds ...

journal_title：Chemotherapy

authors： Kachroo BB

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients th...

journal_title：Chemotherapy

authors： Frielink LM,Pijlman BM,Ezendam NP,Pijnenborg JM

更新日期：2016-01-01 00:00:00

abstract：:In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...

journal_title：Chemotherapy

authors： Tanaka M,Otsuki M,Nishino T

更新日期：1992-01-01 00:00:00

abstract：:The antimicrobial susceptibility and in vitro growth curve of 4 nonencapsulated and 4 encapsulated isolates of Bacteroides fragilis were determined for clindamycin. The MIC of the nonencapsulated isolates was 1-2 dilutions less (0.062-0.25 microgram/ml) than the MIC for their encapsulated counterparts (0.25-0.5 microg...

journal_title：Chemotherapy

authors： Brook I,Gillmore JD

更新日期：1994-01-01 00:00:00

abstract：:108 white rats weighing 170-250 G were given trimethoprim, sulphamethoxazole and the combination trimethoprim 1/sulphamethoxazole orally and parenterally in order to test the preventive effect of these substances on experimental hematogenous pyelonephritis due to Staphylococcus aureus. Oral applications of 48 mg/kg/24...

journal_title：Chemotherapy

authors： Obek A,Anğ O,Iplikçi A,Güvener Z,Eroğlu L,Güngör M,Yurtkuran M

更新日期：1975-01-01 00:00:00

abstract：:100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...

journal_title：Chemotherapy

authors： Blanc C,Pollet JP,Bauters F

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...

journal_title：Chemotherapy

authors： Komazaki Y,Sakashita H,Furuiye M,Fujie T,Tamaoka M,Sumi Y,Miyazaki Y,Kojima K,Jin Y,Inase N

更新日期：2013-01-01 00:00:00

abstract：:Antibacterial kinetics of modified-release clarithromycin (CLA) and azithromycin (AZI) against respiratory tract pathogens were compared in relation to their pharmacokinetic profile. The study was carried out in three strains of Streptococcus pneumoniae, group A beta-hemolytic Streptococcus pyogenes, Moraxella catarrh...

journal_title：Chemotherapy

authors： Scaglione F,Demartini G,Dugnani S,Fraschini F

更新日期：2000-09-01 00:00:00

abstract：:137 patients with febrile neutropenia after cytotoxic therapy not responding to ceftazidime plus or ceftriaxone plus netilmicin in received additionally to the previous combination either vancomycin alone or combined with another anti-gram-negative compound: imipenem in those treated prophylactically with ofloxacin an...

journal_title：Chemotherapy

authors： Lacka J,Oravcova E,Sevcikova L,Studena M,Bachanova V,Kukuckova E,Spanik S,Sufliarsky J,Helpianska L,Trupl J,Kunova A,Vochyanova I,Sycova Z,Grey E,Krcméry V Jr

更新日期：1996-03-01 00:00:00

abstract：:We studied penicillin-binding protein (PBP) profiles of two Pseudomonas aeruginosa strains stably derepressed for constitutive, type Id beta-lactamase overproduction. Substantial levels of beta-lactamase were found to be strongly associated with isolated inner membranes of these two strains, as well as from a plasmid-...

journal_title：Chemotherapy

authors： Parr TR Jr,Chan L,Bayer AS

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...

journal_title：Chemotherapy

authors： Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the antimicrobial susceptibility patterns among common pathogens in the intensive care unit (ICU) of a university hospital in Iran between 2006 and 2009. METHODS:The isolates cultured in appropriate media and antimicrobial susceptibility were determined by disk diffusio...

journal_title：Chemotherapy

authors： Mohammadtaheri Z,Pourpaki M,Mohammadi F,Namdar R,Masjedi MR

更新日期：2010-01-01 00:00:00

abstract：:The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to r...

journal_title：Chemotherapy

authors： Kamberi P,Atsuro H,Takayoshi T,Masaru N

更新日期：1998-01-01 00:00:00

abstract：:Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind, randomized, parallel-group study was designed to demonstrate the lack of effect of steady-state concentrations of gemifloxacin on the pharmacodynamic effects of warfarin. Healthy male subjects received loading doses of warfar...

journal_title：Chemotherapy

authors： Davy M,Bird N,Rost KL,Fuder H

更新日期：1999-11-01 00:00:00

abstract：:Neither cefoperazone, cefotaxime, mezlocillin nor piperacillin significantly killed intraphagocytic bacteria of representative assay strains of Serratia marcescens, as determined with 55 vol% of fresh defibrinated human blood treated with 2 mg/ml of phenylbutazone, which permitted phagocytic ingestion of bacteria, but...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1983-01-01 00:00:00

abstract：:Contrary to L-lysine, D-lysine showed no inhibitory effect on growth of Ehrlich ascites tumour cell in in vivo studies. The in vitro studies on the growth of cultured Ehrlich ascites tumour cells showed similar results, namely, the growth of tumour cells was inhibited when cultured in 0.02 or 0.03 M L-lysine; while 0....

journal_title：Chemotherapy

authors： Choy YM,Fung KP

更新日期：1989-01-01 00:00:00

abstract：:Fifty-two children (mean age 23 months) with acute otitis media were treated randomly with either a single intramuscular dose of ceftriaxone (Rocephin) 50 mg/kg (27 patients) or 7 days of amoxicillin 12.5 mg/kg t.i.d. (25 patients). The rate of resolution of acute symptoms and incidence of recurrences and relapses dur...

journal_title：Chemotherapy

authors： Varsano I,Frydman M,Amir J,Alpert G

更新日期：1988-01-01 00:00:00