Abstract:
BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation with a defined flow under hypoxic conditions. The pH changes under stop-flow therapy may affect the further metabolism of 5-fluorouracil (5-FU), used here. METHODS:The in vitro 5-fluoro-2'-deoxyuridine (5-FUrd) concentrations at increasing pH values were measured using liposomal encapsulated and free 5-FU. Subsequently, 20 chinchilla rabbits were treated intra-aortally with 5-FU or 5-FU-polyethylene glycol (PEG) liposomes. The pH value was maintained in the physiological range by continuous NaHCO3 application. After 20 min, concentrations of 5-FU and its metabolite 5-FUrd were determined in different organs, the perfusate, serum and the VX-2 tumor by HPLC. RESULTS:The in vitro 5-FUrd concentrations, which occur only in the physiological pH range, were doubled by the use of 5-FU-PEG liposomes. In the animal trial, NaHCO(3) titration doubled the 5-FUrd concentrations found in our preliminary studies. Compared to free 5-FU, 5-FU-PEG liposomes significantly increased the concentrations in the VX-2 liver tumor by 6.6-fold and in the para-aortal lymph nodes by 8.76-fold. CONCLUSION:The metabolism of 5-FU into its active metabolite 5-FUrd depends on the pH value and can be modulated. 5-FUrd concentrations can be approximately doubled with the intra-aortal application of 5-FU-PEG liposomes compared to free 5-FU.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger Gdoi
10.1159/000077805subject
Has Abstractpub_date
2004-06-01 00:00:00pages
67-75issue
2eissn
0009-3157issn
1421-9794pii
77805journal_volume
50pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract:PURPOSE:To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS:We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate esc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000450748
更新日期:2017-01-01 00:00:00
abstract::Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238817
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000328027
更新日期:2011-01-01 00:00:00
abstract::A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it bi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238314
更新日期:1985-01-01 00:00:00
abstract::Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not lik...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000081992
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048581
更新日期:2002-03-01 00:00:00
abstract::Fifty-two children (mean age 23 months) with acute otitis media were treated randomly with either a single intramuscular dose of ceftriaxone (Rocephin) 50 mg/kg (27 patients) or 7 days of amoxicillin 12.5 mg/kg t.i.d. (25 patients). The rate of resolution of acute symptoms and incidence of recurrences and relapses dur...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238646
更新日期:1988-01-01 00:00:00
abstract::Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000049159
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000099985
更新日期:2007-01-01 00:00:00
abstract::Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323623
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000118663
更新日期:2008-01-01 00:00:00
abstract::Silver sulfadiazine was found to be devoid of mutagenic potential in a sensitive mutagenicity assay using Salmonella typhimurium. In view of the close relationship between mutagenicity in this system and carcinogenicity in animals, these findings suggest that silver sulfadiazine is apparently also devoid of carcinogen...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237765
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Combination antimicrobial therapy is often necessary to eradicate infections caused by gram-negative bacteria. METHODS:To evaluate the potential benefit of aztreonam and fluoroquinolone combination therapy, the activity of aztreonam in combination with ciprofloxacin, gatifloxacin, levofloxacin and moxifloxa...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000069786
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323629
更新日期:2011-01-01 00:00:00
abstract::Pyrazinamide (PZA) is an unconventional frontline tuberculosis drug characterized by high in vivo sterilizing activity, but poor in vitro activity. The study on the mechanism of action of PZA has attracted significant attention because of the peculiarity of PZA and its ability to shorten the tuberculosis chemotherapy....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000107723
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000088952
更新日期:2005-10-01 00:00:00
abstract::Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007258
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000321028
更新日期:2011-01-01 00:00:00
abstract::The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a d...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239338
更新日期:1995-05-01 00:00:00
abstract::Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239014
更新日期:1992-01-01 00:00:00
abstract::Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238433
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048545
更新日期:2001-09-01 00:00:00
abstract:AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000338383
更新日期:2012-01-01 00:00:00
abstract::Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238297
更新日期:1984-01-01 00:00:00
abstract::CPC10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1-12, 1981], CPC10997 was found to b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238360
更新日期:1985-01-01 00:00:00
abstract::The affinity of meropenem for various known types of beta-lactamases and its stability to them were tested in comparison with other beta-lactams, including imipenem. Meropenem exhibited a marked stability to all beta-lactamases tested and was only hydrolyzed by Xanthomonas maltophilia beta-lactamase, as were other bet...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239004
更新日期:1992-01-01 00:00:00
abstract::The in vitro bactericidal effects of therapeutic concentrations of levofloxacin (LVFX) on clinical isolates of Pseudomonas aeruginosa and Enterococcus faecalis were assessed. Starting from 10(7) CFU/ml, the bacterial count was determined serially during the exposure to LVFX present at concentrations automatically simu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007133
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS:Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal t...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000337088
更新日期:2012-01-01 00:00:00
abstract::Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents w...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000237811
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000453446
更新日期:2017-01-01 00:00:00