Abstract:
BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a 2-week period of no treatment. Carboplatin was given intravenously on day 8 at an area under the curve of 6. This regimen was repeated for four to six 28-day courses. RESULTS:Seventeen patients were enrolled in this study. Fourteen of them completed at least 4 cycles of chemotherapy. Nine patients had grade 2 and three patients had grade 3 thrombocytopenia, respectively. Severe nonhematologic toxicities were uncommon. Treatment was delayed in a few patients because of prolonged thrombocytopenia. CONCLUSION:We concluded that the regimen was feasible and tolerable for patients with completely resected NSCLC as adjuvant chemotherapy.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Komazaki Y,Sakashita H,Furuiye M,Fujie T,Tamaoka M,Sumi Y,Miyazaki Y,Kojima K,Jin Y,Inase Ndoi
10.1159/000351101subject
Has Abstractpub_date
2013-01-01 00:00:00pages
35-41issue
1eissn
0009-3157issn
1421-9794pii
000351101journal_volume
59pub_type
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