Abstract:
BACKGROUNDS:The combination gemcitabine-oxaliplatin (GEMOX) is frequently used in patients with advanced biliary tract carcinoma (BTC). However, this is only based on phase II studies performed in selected patients.We assessed the efficacy and safety of the GEMOX regimen in non-selected patients with advanced BTC. METHODS:All consecutive patients with advanced BTC received the GEMOX regimen in a setting outside a study: gemcitabine 1,000 mg/m(2) on day 1, and oxaliplatin 100 mg/m(2) on day 2, treatment repeated every 2 weeks until progression or unacceptable toxicity. RESULTS:Forty-four patients were enrolled. EFFICACY:1 complete and 6 partial responses (objective response rate = 16.3%), 18 tumour stabilizations (41.9%, disease control rate = 58.1%), median progression-free survival was 5.0 months and median overall survival was 11.0 months. TOXICITY:grade 3 neuropathy in 4 patients, grade 3 asthenia in 5 patients. CONCLUSION:The GEMOX combination was well tolerated, with a modest activity in non-selected patients with advanced BTC. This regimen should be compared to the new standard gemcitabine-cisplatin combination.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Hollebecque A,Bouché O,Romano O,Scaglia E,Cattan S,Zerbib P,Heurgue A,Lagarde S,Mariette C,Triboulet JP,Pruvot FR,Hebbar Mdoi
10.1159/000316848subject
Has Abstractpub_date
2010-01-01 00:00:00pages
234-8issue
3eissn
0009-3157issn
1421-9794pii
000316848journal_volume
56pub_type
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