Abstract:
:Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irreversible stasis of tumor blood flow (TBF), thereby causing necrosis of tumor tissue by halting the supply of nutrients. Such effects were unrelated to cancer type. In this review, we summarize our experiments on antivascular and antitumor effects by AVE8062. We maintain that such starvation tactics against solid tumors constitute a new therapeutic strategy for all solid tumors, including refractory cancers.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Hori Kdoi
10.1159/000088961subject
Has Abstractpub_date
2005-10-01 00:00:00pages
357-60issue
6eissn
0009-3157issn
1421-9794pii
88961journal_volume
51pub_type
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