Abstract:
:We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combination by the checkerboard technique, while amikacin-cefoperazone was the most active combination by the time-killing curve technique against Pseudomonas aeruginosa. Discrepancies were found between the results of the two methods used.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Alvarez S,Jones M,Holtsclaw-Berk S,Berk SLdoi
10.1159/000238556subject
Has Abstractpub_date
1988-01-01 00:00:00pages
107-12issue
2eissn
0009-3157issn
1421-9794journal_volume
34pub_type
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