Abstract:
:Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentration, RMP was considerably more active than the other two substances in vitro. However, the rate of bactericidal effect was similar for all three drugs. In vivo, the minimum bactericidal dietary dosages of RMP, B663 and B1912 were 0.03, 0.03 and less than or equal to 0.01%, respectively. Results suggest that these drugs may be of value for the treatment of clinical M. marinum infections.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Banerjee DK,Holmes IBdoi
10.1159/000221931subject
Has Abstractpub_date
1976-01-01 00:00:00pages
242-52issue
3-4eissn
0009-3157issn
1421-9794journal_volume
22pub_type
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