Abstract:
:Studies are presented on the in vitro phagocytic activity of rat and human polymorphonuclear leukocytes exposed in vivo to therapeutic concentrations of doxycycline. A 32P-labelled strain of Escherichia coli served as test microbe. No significant reduction of ingestion was observed although untreated AB leukocytes tested together with serum containing doxycycline showed a nonsignificant reduction in ingestive capability (p = 0.1). A similar pattern was observed when rat polymorphonuclear cells were tested omitting serum during the ingestion phase. In the presence of serum no effects were observed. During the elimination phase (3 h) both rat and human PMN eliminated breakdown products more extensively than controls, the effect observed on human PMN being most pronounced by the use of serum containing doxycycline.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Melby K,Midtvedt Tdoi
10.1159/000238015subject
Has Abstractpub_date
1981-01-01 00:00:00pages
452-8issue
6eissn
0009-3157issn
1421-9794journal_volume
27pub_type
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