Abstract:
:The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a detected in the susceptible strain. For each beta-lactam antibiotic tested, there appeared to be significant decreases in the affinity for BPB 1b, 2a and 2b of the resistant strains. We attempted to evaluate a quantitative correlation between the antibacterial activity of the drugs for three strains and their affinity for the various PBPs. A close correlation was found between the minimum inhibitory concentrations and the affinity for PBP 2a, but not for any of the other PBPs.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Ikeda F,Yokota Y,Ikemoto A,Teratani N,Shimomura K,Kanno Hdoi
10.1159/000239338subject
Has Abstractpub_date
1995-05-01 00:00:00pages
159-64issue
3eissn
0009-3157issn
1421-9794journal_volume
41pub_type
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