Interaction of beta-lactam antibiotics with the penicillin-binding proteins of penicillin-resistant Streptococcus pneumoniae.

Abstract:

:The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a detected in the susceptible strain. For each beta-lactam antibiotic tested, there appeared to be significant decreases in the affinity for BPB 1b, 2a and 2b of the resistant strains. We attempted to evaluate a quantitative correlation between the antibacterial activity of the drugs for three strains and their affinity for the various PBPs. A close correlation was found between the minimum inhibitory concentrations and the affinity for PBP 2a, but not for any of the other PBPs.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Ikeda F,Yokota Y,Ikemoto A,Teratani N,Shimomura K,Kanno H

doi

10.1159/000239338

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

159-64

issue

3

eissn

0009-3157

issn

1421-9794

journal_volume

41

pub_type

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