Abstract:
:Aztreonam is the first monobactam antibiotic to be used clinically. It is highly resistant to beta-lactamases, and although its activity spectrum is similar to that of the aminoglycoside antibiotics, it has no effect on gram-positive bacteria. The current study was undertaken to determine the efficacy of aztreonam in treating gram-negative infections caused by multiresistant microorganisms in patients with known sensitivity to penicillins and cephalosporins. Sixty-six patients presented with urinary tract infection (UTI) and 30 with respiratory tract infection (RTI). All patients received aztreonam, between 4 and 6 g/day in divided doses for 10-14 days. Cure was achieved in 59 (89.3%) patients with UTI; in the group with RTI, 20 patients were cured and 4 improved with treatment. Tolerance to the drug was good in both groups, and in no instance did side effects necessitate modification of the dosing regimen.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Schönwald S,Schoss-Vidensek Z,Car V,Krznar Bdoi
10.1159/000238720subject
Has Abstractpub_date
1989-01-01 00:00:00pages
45-8eissn
0009-3157issn
1421-9794journal_volume
35 Suppl 1pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000238006
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000091307
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000099985
更新日期:2007-01-01 00:00:00
abstract::The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222052
更新日期:1977-01-01 00:00:00
abstract::Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238423
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000488538
更新日期:2018-01-01 00:00:00
abstract::Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239370
更新日期:1995-09-01 00:00:00
abstract::A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238664
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000287351
更新日期:2010-01-01 00:00:00
abstract::A-56619 and A-56620 are two new quinolone compounds that are currently being studied. They were found to be active against multi-resistant and routine isolates of Staphylococcus aureus, enterobacteria, aminoglycoside-sensitive and resistant strains of Pseudomonas aeruginosa. Most of the enterobacteria were inhibited b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238573
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Taxanes cause hypersensitivity reactions, averted by premedication with H1 blockers and high glucocorticoid (GC) doses. Prolonged weekly taxane administration may lead to GC toxicity. PURPOSE:To determine whether patients not hypersensitive to initial paclitaxel (PTX) infusion after high-dose GC premedicati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000085618
更新日期:2005-05-01 00:00:00
abstract::CPC10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1-12, 1981], CPC10997 was found to b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238360
更新日期:1985-01-01 00:00:00
abstract::In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238938
更新日期:1992-01-01 00:00:00
abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....
journal_title:Chemotherapy
pub_type:
doi:10.1159/000499375
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...
journal_title:Chemotherapy
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000502510
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:To identify parameters/factors that may contribute to the differential sensitivity to etoposide in two clones isolated from the human ovarian carcinoma SKOV-3 cell line, which does not express p53 and is resistant to platinum-based regimens. METHODS:Differential sensitivity of the cells to etoposide was mon...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000093009
更新日期:2006-01-01 00:00:00
abstract::Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238151
更新日期:1982-01-01 00:00:00
abstract::We evaluated the efficacy of S-1 as a new oral antitumor agent in ovarian cancer-bearing nude rats. This drug consists of tegafur, 5-chloro-2,4-dihydroxypyridine, and oxonic acid in a molar ratio of 1:0.4:1.S-1 was given alone or in combination with cisplatin. When administered alone at a daily dose of 20 mg/ kg, S-1 ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239479
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND/AIMS:Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice of antimicrobial treatment. The reason is predictable clinical significance and the susceptibility profile of specific NTM species. Matrix-assisted laser desorption/ionizatio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000442517
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000066765
更新日期:2002-12-01 00:00:00
abstract::The antimicrobial susceptibility and in vitro growth curve of 4 nonencapsulated and 4 encapsulated isolates of Bacteroides fragilis were determined for clindamycin. The MIC of the nonencapsulated isolates was 1-2 dilutions less (0.062-0.25 microgram/ml) than the MIC for their encapsulated counterparts (0.25-0.5 microg...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239164
更新日期:1994-01-01 00:00:00
abstract::Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238344
更新日期:1985-01-01 00:00:00
abstract::Sixteen adult beagles (10-12 kg) were used to evaluate combinations of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ, aziridinylbenzoquinone), 1,3-bis-2-chloroethyl-1-nitrosourea (BCNU, carmustine), and cis-dichlorodiammineplatinum(II) (CDDP, cisplatin) administered by intravenous or intracarotid infu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238532
更新日期:1987-01-01 00:00:00
abstract::Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237980
更新日期:1981-01-01 00:00:00
abstract::The concentrations of clarithromycin after a single oral dose of 500 mg were determined in serum and saliva of ten healthy adult volunteers. After 2 h, the levels were 4.04 +/- 1.14 (SD) mg/l in serum and 2.72 +/- 0.87 mg/l in saliva. After 7 h these values were 1.98 +/- 0.65 and 1.21 +/- 0.34 mg/l, respectively, and ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239139
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring s...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000333377
更新日期:2011-01-01 00:00:00
abstract::Community-acquired pneumonia (CAP) is a common illness that creates significant burdens upon the healthcare system. Improving the quality of medical care for patients with this illness requires an evidence-based and cost-efficient treatment approach. The first step in this approach is to make an accurate diagnosis, wh...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000049174
更新日期:2001-01-01 00:00:00
abstract::Gametocytocidal activity of artemisinin (qinghaosu) has been demonstrated against simian malaria parasite Plasmodium cynomolgi B. Colony-bred Anopheles stephensi were allowed to feed on gametocyte-carrying rhesus monkeys and the mosquito infectivity rate and oocyst count of the infected mosquito gut were recorded on d...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238671
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and tolerability of hepatic arterial infusion (HAI) of gemcitabine plus oxaliplatin as second-line treatment for unresectable locally advanced intrahepatic cholangiocarcinoma. PATIENTS AND METHODS:We retrospectively analyzed the outcome of 12 consecutive pa...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000362223
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000475879
更新日期:2017-01-01 00:00:00