Abstract:
:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to peak serum concentrations were approximately 3% for each antimicrobial. However, the more prolonged sputum concentrations of piperacillin were reflected in greater areas under the sputum concentration-time curve and a longer duration above the MIC50 of tested P. aeruginosa strains for that drug.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Laferriere C,Stutman HR,Marks MI,Kramer J,Flux Mdoi
10.1159/000238344subject
Has Abstractpub_date
1985-01-01 00:00:00pages
255-60issue
4eissn
0009-3157issn
1421-9794journal_volume
31pub_type
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