Rifampicin in free combination with other antimicrobial drugs in non-Tb infections. Clinical data on 650 patients (a review).

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：:During the 5-year period 1989-1993, the incidence of Candida krusei, and other non-albicans Candida spp., was analyzed in a 60-bed cancer department. The frequency of C. krusei, before fluconazole was introduced into therapeutic protocols in 1990, was 16.5%, and after introduction of fluconazole into prophylaxis in ac...

journal_title：Chemotherapy

authors： Kunová A,Trupl J,Spánik S,Drgona L,Sufliarsky J,Lacka J,Studená V,Hlavácová E,Studená M,Kukucková E

更新日期：1995-01-01 00:00:00

abstract：:Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...

journal_title：Chemotherapy

authors： Yamabe S

更新日期：1980-01-01 00:00:00

abstract：:Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae. The minimal inhibitory concentrations (MICs) and their ranges of meropenem and imipenem using five beta-lactamase-producing strain...

journal_title：Chemotherapy

authors： Yourassowsky E,Van der Linden MP,Crokaert F

更新日期：1991-01-01 00:00:00

abstract：:Viscum album (VA) preparations consist of aqueous extracts of V. album, the European mistletoe. VA extracts contain mistletoe lectins, which are members of the ribosome-inactivating protein type II family. VA preparations have cytotoxic and immunomodulatory properties. Cytotoxicity induced by VA extracts may differ gr...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Delignat S,Kazatchkine MD,Kaveri SV

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Combination antimicrobial therapy is often necessary to eradicate infections caused by gram-negative bacteria. METHODS:To evaluate the potential benefit of aztreonam and fluoroquinolone combination therapy, the activity of aztreonam in combination with ciprofloxacin, gatifloxacin, levofloxacin and moxifloxa...

journal_title：Chemotherapy

authors： Critchley IA,Sahm DF,Kelly LJ,Karlowsky JA

更新日期：2003-05-01 00:00:00

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：:The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resis...

journal_title：Chemotherapy

authors： Alonso P

更新日期：1979-01-01 00:00:00

abstract：:The effects of the sub-MIC of antibiotics on the surface hydrophobicity and charge of Staphylococcus aureus were examined by the contact angle method and by microscopic electrophoresis, and the production of oxygen-derived radicals by mouse peritoneal macrophages was measured by a luminol-chemiluminescence assay. The ...

journal_title：Chemotherapy

authors： Nomura S,Kuroiwa A,Nagayama A

更新日期：1995-03-01 00:00:00

abstract：:The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The para...

journal_title：Chemotherapy

authors： Meldrum JB,Gupta VS,Babiuk LA

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The brain is a frequent site of metastases in small-cell lung cancer. Symptoms of cerebral involvement are headache, disorientation, nausea/vomiting and seizures. CASE:A man with small-cell lung cancer developed a human herpesvirus 6 (HHV-6) meningoencephalitis with neurological symptoms that simulated brai...

journal_title：Chemotherapy

authors： Mordenti P,Zaffignani E,Immovilli P,Nobili E,Cavanna L

更新日期：2013-01-01 00:00:00

abstract：:Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...

journal_title：Chemotherapy

authors： Hori K

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...

journal_title：Chemotherapy

authors： Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

更新日期：2004-06-01 00:00:00

abstract：:The antibacterial activity of tobramycin, gentamicin, erythromycin, cloxacillin, kanamycin, cephalexin, penicillin, carbenicillin and polymyxin were compared against 303 clinical bacterial isolates from a pediatric hospital patient population. Standard disk diffusion and agar-dilution methods were employed. Significan...

journal_title：Chemotherapy

authors： Laxer RM,Mackay E,Marks MI

更新日期：1975-01-01 00:00:00

abstract：:Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind, randomized, parallel-group study was designed to demonstrate the lack of effect of steady-state concentrations of gemifloxacin on the pharmacodynamic effects of warfarin. Healthy male subjects received loading doses of warfar...

journal_title：Chemotherapy

authors： Davy M,Bird N,Rost KL,Fuder H

更新日期：1999-11-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...

journal_title：Chemotherapy

authors： Hong A,Leigh BR

更新日期：2002-12-01 00:00:00

abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...

journal_title：Chemotherapy

authors： Fu KP,Grace ME,McCloud SJ,Gregory FJ,Hung PP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Brucellosis is one of the important health problems for both humans and animals in Turkey since agriculture and stock raising appears to be the most important means of subsistence. Investigations on the pathogenesis of brucellosis reveal that the etiologic agent can survive in phagocytic cells, and cell-medi...

journal_title：Chemotherapy

authors： Dizer U,Hayat L,Beker CM,Görenek L,Ozgüven V,Pahsa A

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Enterococci and especially glycopeptide-resistant strains (GRE) are widely distributed in the hospital environment, by acquiring resistance determinants and virulence factors. METHODS:The study included 48 GRE isolated during a 1-year period from different inpatients in a tertiary hospital in southwestern G...

journal_title：Chemotherapy

authors： Kolonitsiou F,Mani V,Parikou H,Trakala M,Dimitracopoulos G,Spiliopoulou I

更新日期：2004-11-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：:Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...

journal_title：Chemotherapy

authors： Horikoshi A,Murphy MJ Jr

更新日期：1985-01-01 00:00:00

abstract：:The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...

journal_title：Chemotherapy

authors： Rees RC,Potter CW,Clegg A,Hall JM

更新日期：1982-01-01 00:00:00

abstract：:The in vitro activities of the newer agents Deptomycin, Difloxacin, A-56620 and Ciprofloxacin were compared with those of vancomycin, rifampin and gentamicin against methicillin-susceptible and -resistant Staphylococcus aureus and coagulase-negative staphylococci. All isolates were susceptible to vancomycin, rifampin,...

journal_title：Chemotherapy

authors： Chandrasekar PH,Sluchak JA

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...

journal_title：Chemotherapy

authors： Wagenlehner FM,Wagenlehner CM,Blenk B,Blenk H,Schubert S,Dalhoff A,Naber KG

更新日期：2011-01-01 00:00:00

abstract：:Data from five clinical trials of amphotericin B colloidal dispersion (ABCD) in the treatment of invasive mycoses were pooled to analyze the renal sparing effects of ABCD. Serum creatinine levels at baseline and either during or at end of treatment were available for 499 of 572 patients (87.2%). The median cumulative ...

journal_title：Chemotherapy

authors： Gurwith M,Mamelok R,Pietrelli L,Du Mond C

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...

journal_title：Chemotherapy

authors： Quan ZW,Yue JN,Li JY,Qin YY,Guo RS,Li SG

更新日期：2008-01-01 00:00:00

abstract：:Studies are presented on the in vitro phagocytic activity of rat and human polymorphonuclear leukocytes exposed in vivo to therapeutic concentrations of doxycycline. A 32P-labelled strain of Escherichia coli served as test microbe. No significant reduction of ingestion was observed although untreated AB leukocytes tes...

journal_title：Chemotherapy

authors： Melby K,Midtvedt T

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. EGFR-targeted therapies show considerable promise, but drug resistance has become a substantial issue...

journal_title：Chemotherapy

authors： Tetsu O,Hangauer MJ,Phuchareon J,Eisele DW,McCormick F

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the antimicrobial susceptibility patterns among common pathogens in the intensive care unit (ICU) of a university hospital in Iran between 2006 and 2009. METHODS:The isolates cultured in appropriate media and antimicrobial susceptibility were determined by disk diffusio...

journal_title：Chemotherapy

authors： Mohammadtaheri Z,Pourpaki M,Mohammadi F,Namdar R,Masjedi MR

更新日期：2010-01-01 00:00:00