Abstract:
:Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae. The minimal inhibitory concentrations (MICs) and their ranges of meropenem and imipenem using five beta-lactamase-producing strains of H. influenzae were 0.03 (0.015-0.06) and 0.6 (0.5-1) micrograms/ml, respectively. Imipenem and meropenem induced spheroplast formation in cultures. Killing curves showed a bacteriostatic activity for meropenem and imipenem for MIC values, and a lag of 2 h in killing for MIC x 2 to MIC x 64. For these concentrations the killing rates of the two antibiotics were similar. Turbidimetric growth curves showed a higher early increase in optical density for meropenem. As far as the MIC value of meropenem was 10 times lower than the MIC value of imipenem, we may conclude that meropenem was more active than imipenem on beta-lactamase-producing strains of H. influenzae.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Yourassowsky E,Van der Linden MP,Crokaert Fdoi
10.1159/000238830subject
Has Abstractpub_date
1991-01-01 00:00:00pages
38-42issue
1eissn
0009-3157issn
1421-9794journal_volume
37pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221879
更新日期:1975-01-01 00:00:00
abstract::Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000239052
更新日期:1992-01-01 00:00:00
abstract::The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007273
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048581
更新日期:2002-03-01 00:00:00
abstract::Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000153315
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Combination antimicrobial therapy is often necessary to eradicate infections caused by gram-negative bacteria. METHODS:To evaluate the potential benefit of aztreonam and fluoroquinolone combination therapy, the activity of aztreonam in combination with ciprofloxacin, gatifloxacin, levofloxacin and moxifloxa...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000069786
更新日期:2003-05-01 00:00:00
abstract::Enterococcus faecalis plays an important role as a pathogen in polymicrobial infections. We evaluated the efficacy of cefozopran (CZOP) using polymicrobial pyometra rats. Rats were infected with a mixed intrauterine inoculation of E. faecalis plus either Bacteroides fragilis or Prevotella bivia (minimal inhibitory con...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007100
更新日期:1998-03-01 00:00:00
abstract::Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checker-board double-dilution test or by killing kinetic studies. However, amdino...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238542
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000337062
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Some new quinolones (NQs) modulate polymorphonuclear leukocyte (PMN) functions. We investigated these effects on PMN functions at concentrations <10 microg/ml. METHODS:Chemotactic activity and the production of reactive oxygen species (ROS) were measured using a 48-well chemotaxis chamber and by luminol-dep...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000232451
更新日期:2009-01-01 00:00:00
abstract::The study of resistance patterns of strains of bacteria to antibiotics in different regions of a country and, if possible, comparing them at international level appears to be a useful exercise. The patterns of resistance during 1968-71 revealed an increasing resistance for most antibiotics with an unexpected increase ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221890
更新日期:1975-01-01 00:00:00
abstract::Oxygen radical generation by blood cells before and after chemotherapy was investigated in 16 elderly (72.8 +/- 1.0 years) and 14 adult (45.0 +/- 2.4 years) patients with lung cancer, using a lucigenin-dependent chemiluminescence method. The oxygen radical generation by 100 microliters of blood before chemotherapy in ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239348
更新日期:1995-05-01 00:00:00
abstract::A total of 5 healthy volunteers were enrolled in a crossover study on the dose dependency and the effect of probenecid on pharmacokinetics of DQ-2556. They were administered intravenously 0.5 and 1.0 g of DQ-2556, and 1.0 g of DQ-2556 with oral administration of probenecid. The linearity in pharmacokinetics of DQ-2556...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239029
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with advanced gastric cancer (AGC) remains poor, and no single chemotherapy regimen is recognized as a global standard. A phase II trial was conducted to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients wi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000305256
更新日期:2010-01-01 00:00:00
abstract::Fifty-two children (mean age 23 months) with acute otitis media were treated randomly with either a single intramuscular dose of ceftriaxone (Rocephin) 50 mg/kg (27 patients) or 7 days of amoxicillin 12.5 mg/kg t.i.d. (25 patients). The rate of resolution of acute symptoms and incidence of recurrences and relapses dur...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238646
更新日期:1988-01-01 00:00:00
abstract::Lower respiratory tract infections are the major cause of death due to infectious disease in the developed and developing world. Despite substantial progress in defining pathogens and in therapeutic options, there continues to be major controversies in the clinical management of these infections. This report reviews t...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000048489
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000090244
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000453446
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000088952
更新日期:2005-10-01 00:00:00
abstract::We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determin...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238590
更新日期:1988-01-01 00:00:00
abstract::The therapeutic efficacy of oral treatment with levofloxacin, ciprofloxacin, and ampicillin on an experimental pneumonia caused by the penicillin-intermediate Streptococcus pneumoniae for which the minimum inhibitory concentrations (MICs) of the quinolones are similar was assessed in immunocompetent CBA/J mice. Levofl...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007181
更新日期:1999-05-01 00:00:00
abstract::Our previous study demonstrated that the effects of isoniazid (INH) on Mycobacterium tuberculosis at the cellular level varied according to the growth phases. In this study, the variations in the INH action on M. avium strain NCTC 8559 are reported. M. avium cells grown on Middlebrook 7H10 agar were harvested at diffe...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000104470
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000218098
更新日期:2009-01-01 00:00:00
abstract::The in vitro activity of the new semisynthetic ureidopenicillins azlocillin (AZ) and mezlocillin (MZ), and of the new cephalosporin cefsulodin (CEF) were determined against 50 carbenicillin-sensitive (CARs) and 50 carbenicillin-resistant (CARr) P. aeruginosa clinical isolates. In the CARs group the most active antibio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237918
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis. PATIENTS AND METHODS:Neuropathy was determined through clinical and electromyographic findings during the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000140466
更新日期:2008-01-01 00:00:00
abstract::Many bis(amidinohydrazones) are potent inhibitors of adenosylmethionine decarboxylase (AdoMetDC), a key enzyme of polyamine biosynthesis, and some of them are also known to be powerful antiviral agents. Therefore, seven bis(amidinohydrazones), including the two most potent inhibitors of eukaryotic AdoMetDC so far repo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238790
更新日期:1990-01-01 00:00:00
abstract::The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238068
更新日期:1982-01-01 00:00:00
abstract::Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic of soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominant...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222080
更新日期:1977-01-01 00:00:00
abstract::Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007258
更新日期:2000-01-01 00:00:00
abstract::A rational choice of an antimicrobial agent must take into account not only the activity against the specific pathogen but also any possible negative or positive effects on the host defense system. Rokitamycin (RKM) is an orally active 16-membered-ring macrolide; there are no reports of specific investigations of thes...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239560
更新日期:1997-05-01 00:00:00