Effects of isoniazid on viability, cell morphologies and acid fastness properties of Mycobacterium avium NCTC 8559 during the growth cycle.

abstract：:The in vitro activity of the new semisynthetic ureidopenicillins azlocillin (AZ) and mezlocillin (MZ), and of the new cephalosporin cefsulodin (CEF) were determined against 50 carbenicillin-sensitive (CARs) and 50 carbenicillin-resistant (CARr) P. aeruginosa clinical isolates. In the CARs group the most active antibio...

journal_title：Chemotherapy

authors： Perea EJ,Palomares JC,García-Iglesias MC

更新日期：1980-01-01 00:00:00

abstract：:Owing to the predominance of gram-positive pathogens in neutropenic cancer patients, newer generation quinolones with an expanded gram-positive spectrum and enhanced potency, may have a role to play for prophylaxis and/or empiric therapy in such patients. The in vitro activity of gatifloxacin was compared with that of...

journal_title：Chemotherapy

authors： Rolston KV,Vaziri I,Frisbee-Hume S,Streeter H,LeBlanc B

更新日期：2004-11-01 00:00:00

abstract：:Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopo...

journal_title：Chemotherapy

authors： Wong CK,Fung KP,Kong SK,Lee CY,Choy YM

更新日期：1995-09-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...

journal_title：Chemotherapy

authors： Mese H,Sasaki A,Alcalde RE,Nakayama S,Matsumura T

更新日期：2000-01-01 00:00:00

abstract：:Fifty-two children (mean age 23 months) with acute otitis media were treated randomly with either a single intramuscular dose of ceftriaxone (Rocephin) 50 mg/kg (27 patients) or 7 days of amoxicillin 12.5 mg/kg t.i.d. (25 patients). The rate of resolution of acute symptoms and incidence of recurrences and relapses dur...

journal_title：Chemotherapy

authors： Varsano I,Frydman M,Amir J,Alpert G

更新日期：1988-01-01 00:00:00

abstract：:Minimal bactericidal concentrations of trimethoprim, nalidixic acid, and nitrofurantoin revealed effective intraphagolysosomal bactericidal activity against several assay strains of Serratia marcescens as determined with phenylbutazone-treated (2 mg/ml) fresh defibrinated human blood (55 vol%), following killing of ex...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1982-01-01 00:00:00

abstract：:New fluoroquinolones, as exemplified by levofloxacin, possess broad spectrum activity against many common pathogens, including the majority responsible for respiratory tract infections (RTIs), atypical pathogens and those resistant to other therapeutic regimens. Following administration, levofloxacin attains high intr...

journal_title：Chemotherapy

authors： Graninger W,Zeitlinger M

更新日期：2004-01-01 00:00:00

abstract：:Uptake of the bifunctional alkylating agent, PTT.119, p-F-Phe-m-bis-(2-chloroethyl)amino-L-Phe-Met-ethoxy-HCl, by the MJY-alpha mammary tumor and B16 melanoma cell lines occurred via two natural pathways for amino acid transport. The primary route of PTT.119 entry was the classical L System, whereas, the ASC System ca...

journal_title：Chemotherapy

authors： Yagi MJ,Scanlon KJ,Chin SE,Bekesi JG

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00

abstract：:108 white rats weighing 170-250 G were given trimethoprim, sulphamethoxazole and the combination trimethoprim 1/sulphamethoxazole orally and parenterally in order to test the preventive effect of these substances on experimental hematogenous pyelonephritis due to Staphylococcus aureus. Oral applications of 48 mg/kg/24...

journal_title：Chemotherapy

authors： Obek A,Anğ O,Iplikçi A,Güvener Z,Eroğlu L,Güngör M,Yurtkuran M

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:Species-level identification of nontuberculous mycobacteria (NTM) is important in making decisions about the necessity and choice of antimicrobial treatment. The reason is predictable clinical significance and the susceptibility profile of specific NTM species. Matrix-assisted laser desorption/ionizatio...

journal_title：Chemotherapy

authors： Mareković I,Bošnjak Z,Jakopović M,Boras Z,Janković M,Popović-Grle S

更新日期：2016-01-01 00:00:00

abstract：:Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...

journal_title：Chemotherapy

authors： Draenert FG,Draenert K

更新日期：2008-01-01 00:00:00

abstract：:The in vitro activity of sparfloxacin, a new fluoroquinolone, was compared with ciprofloxacin and ofloxacin against 166 consecutive isolates from the upper respiratory tract of outpatients. The strains were fully susceptible to three quinolones. The antibacterial activity of sparfloxacin was comparable or better than ...

journal_title：Chemotherapy

authors： Malmborg AS,Ahlén S

更新日期：1993-01-01 00:00:00

abstract：:Sixteen adult beagles (10-12 kg) were used to evaluate combinations of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ, aziridinylbenzoquinone), 1,3-bis-2-chloroethyl-1-nitrosourea (BCNU, carmustine), and cis-dichlorodiammineplatinum(II) (CDDP, cisplatin) administered by intravenous or intracarotid infu...

journal_title：Chemotherapy

authors： Wright KC,Stephens LC,Wallace S,Savaraj N,Feun LG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：:28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages o...

journal_title：Chemotherapy

authors： Ball AP,Brookes GR,Farrell ID,Geddes AM,Gould I

更新日期：1979-01-01 00:00:00

abstract：:Within recent years, novel serological and molecular methods have been developed to improve the early diagnosis of invasive fungal infections especially in patients with malignant hematological diseases being at highest risk of developing these life-threatening infections. Early diagnosis is essential for adequate the...

journal_title：Chemotherapy

authors： Buchheidt D,Skladny H,Baust C,Hehlmann R

更新日期：2000-05-01 00:00:00

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：:Twenty Pseudomonas maltophilia isolates were examined for susceptibility to beta-lactam antibiotics, including carbapenems, and for beta-lactamase production. All the isolates were resistant to imipenem (MICs 64-512 mg/l) and to a lesser extent, to meropenem (MICs 16-256 mg/l). None of the isolates produced significan...

journal_title：Chemotherapy

authors： Cullmann W,Dick W

更新日期：1990-01-01 00:00:00

abstract：:We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...

journal_title：Chemotherapy

authors： Brown R

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...

journal_title：Chemotherapy

authors： Zhou C,Li X,Du W,Feng Y,Kong X,Li Y,Xiao L,Zhang P

更新日期：2010-01-01 00:00:00

abstract：:A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...

journal_title：Chemotherapy

authors： Skerk V,Mareković I,Markovinović L,Begovac J,Skerk V,Barsić N,Majdak-Gluhinić V

更新日期：2006-01-01 00:00:00

abstract：:Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...

journal_title：Chemotherapy

authors： Melloni D,Ammatuna P,Formica P,Falletta V,Gaglio F,Cacciatore M,Messina G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...

journal_title：Chemotherapy

authors： Ozbek B,Otuk G

更新日期：2009-01-01 00:00:00

abstract：:Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind, randomized, parallel-group study was designed to demonstrate the lack of effect of steady-state concentrations of gemifloxacin on the pharmacodynamic effects of warfarin. Healthy male subjects received loading doses of warfar...

journal_title：Chemotherapy

authors： Davy M,Bird N,Rost KL,Fuder H

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...

journal_title：Chemotherapy

authors： Kurosaki I,Hatakeyama K

更新日期：2005-10-01 00:00:00

abstract：:The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin. Synergistic antibacterial action (defined as FIC index less than or equal to 0.5) w...

journal_title：Chemotherapy

authors： Kern W,Gulden H,Vanek E,Kurrle E

更新日期：1988-01-01 00:00:00

abstract：:The treatment of diffuse large B-cell lymphoma in the presence of cardiac comorbidities can be challenging considering that the standard treatment regimen used for this aggressive subtype of non-Hodgkin lymphoma (NHL) consists of a combination of rituximab, cyclophosphamide, doxorubicin hydrochloride, Oncovin (vincris...

journal_title：Chemotherapy

authors： Alrifai T,Grant Szymanski K,Venugopal P,Mahon B,Okwuosa T,Karmali R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Chronic hepatitis B (CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen (HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our...

journal_title：Chemotherapy

authors： Akhan SC,Yulugkural Z,Vahaboglu H

更新日期：2007-01-01 00:00:00

abstract：:Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...

journal_title：Chemotherapy

authors： Korting HC,Niederauer H,Ollert M

更新日期：1986-01-01 00:00:00