Endogenous production of tumor necrosis factor alpha in combination with hyperthermia for the treatment of mice bearing Ehrlich ascites tumor.

abstract：BACKGROUND:Cisplatin (CDDP) is known to cause inner ear damage while carboplatin (CBDCA) induces less ototoxicity than CDDP. We examined apoptotic changes in the cochlea of guinea pigs after injection of CDDP or CBDCA using immunohistochemical and electrophysiological techniques. METHODS:Three days after the injection...

journal_title：Chemotherapy

authors： Watanabe KC,Jinnouchi K,Hess A,Michel O,Baba S,Yagi T

更新日期：2002-05-01 00:00:00

abstract：:Fifty-two children (mean age 23 months) with acute otitis media were treated randomly with either a single intramuscular dose of ceftriaxone (Rocephin) 50 mg/kg (27 patients) or 7 days of amoxicillin 12.5 mg/kg t.i.d. (25 patients). The rate of resolution of acute symptoms and incidence of recurrences and relapses dur...

journal_title：Chemotherapy

authors： Varsano I,Frydman M,Amir J,Alpert G

更新日期：1988-01-01 00:00:00

abstract：:20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...

journal_title：Chemotherapy

authors： Franson TR,Edwards LD,Collins RF,Root TE

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the impact of different temperatures (22, 35 and 37 degrees C) on the postantifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 x MIC) on Candida albicans and Candida glabrata in PAFE stage (PAFSE). METHODS:This stage was induced by a 1.5-hour ...

journal_title：Chemotherapy

authors： García MT,Llorente MT,Mínguez F,Prieto J

更新日期：2000-07-01 00:00:00

abstract：:Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been reported to have a hig...

journal_title：Chemotherapy

authors： Saraswathi V,Ramamoorthy N,Subramaniam S,Mathuram V,Gunasekaran P,Govindasamy S

更新日期：1998-05-01 00:00:00

abstract：:In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...

journal_title：Chemotherapy

authors： Tanaka M,Otsuki M,Nishino T

更新日期：1992-01-01 00:00:00

abstract：:Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentra...

journal_title：Chemotherapy

authors： Banerjee DK,Holmes IB

更新日期：1976-01-01 00:00:00

abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...

journal_title：Chemotherapy

authors： Fu KP,Grace ME,McCloud SJ,Gregory FJ,Hung PP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...

journal_title：Chemotherapy

authors： Lee MG,Lee SH,Lee SJ,Lee YS,Hwang JH,Ryu JK,Kim YT,Kim DU,Woo SM

更新日期：2013-01-01 00:00:00

abstract：:Gemifloxacin is a novel fluoroquinolone with a broad spectrum of activity. This double-blind, randomized, parallel-group study was designed to demonstrate the lack of effect of steady-state concentrations of gemifloxacin on the pharmacodynamic effects of warfarin. Healthy male subjects received loading doses of warfar...

journal_title：Chemotherapy

authors： Davy M,Bird N,Rost KL,Fuder H

更新日期：1999-11-01 00:00:00

abstract：:The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus. Subminimal inhibitory concentrations of CZX inhibited the growth of bacteria. Normal human serum as a source of complement and low doses of CZX, such as 1/20...

journal_title：Chemotherapy

authors： Watanabe K,Kin R,Murakami M,Kondo M

更新日期：1986-01-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...

journal_title：Chemotherapy

authors： Mese H,Sasaki A,Alcalde RE,Nakayama S,Matsumura T

更新日期：2000-01-01 00:00:00

abstract：:Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized ...

journal_title：Chemotherapy

authors： Maraki S,Barbounakis E,Chatzinikolaou I,Anatoliotakis N,Plataki M,Tselentis Y,Samonis G

更新日期：1998-11-01 00:00:00

abstract：:We have compared the antibacterial activities of cephalexin and cephradine against Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus (Micrococcus spp. type III), and group B streptococci (35 strains in total), using the Biophotometer. Analysis of growth curves obtained in the presence of ...

journal_title：Chemotherapy

authors： Brumfitt W,Hamilton-Miller JM

更新日期：1982-01-01 00:00:00

abstract：:The antibacterial activity of tobramycin, gentamicin, erythromycin, cloxacillin, kanamycin, cephalexin, penicillin, carbenicillin and polymyxin were compared against 303 clinical bacterial isolates from a pediatric hospital patient population. Standard disk diffusion and agar-dilution methods were employed. Significan...

journal_title：Chemotherapy

authors： Laxer RM,Mackay E,Marks MI

更新日期：1975-01-01 00:00:00

abstract：:The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative ba...

journal_title：Chemotherapy

authors： Renzini G,Ravagnan G,Oliva B

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...

journal_title：Chemotherapy

authors： Rotte A,Garmann D,Buss I,Jaehde U

更新日期：2010-01-01 00:00:00

abstract：:We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combina...

journal_title：Chemotherapy

authors： Alvarez S,Jones M,Holtsclaw-Berk S,Berk SL

更新日期：1988-01-01 00:00:00

abstract：:On the basis of a regression analysis of the correlation between minimal inhibitory concentration (MIC) and inhibitory zone diameter, interpretative criteria are established for the agar diffusion test with ceftriaxone disks (30 micrograms) in DST agar according to the DIN method. The correlation is good (r = -0.9242)...

journal_title：Chemotherapy

authors： Grimm H

更新日期：1984-01-01 00:00:00

abstract：:A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...

journal_title：Chemotherapy

authors： van Rensburg CE,Dekker J,Weis R,Smith TL,Janse van Rensburg E,Schneider J

更新日期：2002-07-01 00:00:00

abstract：:A narcissus alkaloid, pretazettine hydrochloride (PTZ), has been shown to be active against Ehrlich ascites carcinoma. The Ehrlich cells are more sensitive to PTZ in DBA/2 mice than in Swiss mice. The therapeutic activity of the individual standard drugs in ABC (adriamycin, BCNU, and cyclophosphamide) regimen against ...

journal_title：Chemotherapy

authors： Furusawa E,Lum MK,Furusawa S

更新日期：1981-01-01 00:00:00

abstract：:A rational choice of an antimicrobial agent must take into account not only the activity against the specific pathogen but also any possible negative or positive effects on the host defense system. Rokitamycin (RKM) is an orally active 16-membered-ring macrolide; there are no reports of specific investigations of thes...

journal_title：Chemotherapy

authors： Braga PC,Maci S,Dal Sasso M,Fonti E,Ghessi A

更新日期：1997-05-01 00:00:00

abstract：:We have tested the effectiveness of several antibiotic regimens, using a rat model of Escherichia coli experimental pyelonephritis that mimics the conditions of severe renal infections in man because the infection is acquired by the ascending route. We found that ceftriaxone, when given for 5 days to rats with severe ...

journal_title：Chemotherapy

authors： Glauser MP,Bonard

更新日期：1982-01-01 00:00:00

abstract：:CPC10997 was found to be effective in vitro as an antiandrogen without effects on either the estrogen or the progesterone receptors in carcinomas of the breast, ovary and prostate as well as in malignant melanomas. Using the clonogenic assay of Salmon et al. [Cancer Treat. Rep. 65: 1-12, 1981], CPC10997 was found to b...

journal_title：Chemotherapy

authors： Ford LC,Kasha W,Chang NH,DeLange RJ

更新日期：1985-01-01 00:00:00

abstract：:Ocular penetration of grepafloxacin into several ocular tissues was determined in albino and pigmented rabbits following a single intravitreal administration. After administration, grepafloxacin was detected in all ocular tissues studied in both breeds of rabbits. The superior mean penetration ratios were found in the...

journal_title：Chemotherapy

authors： Solans C,Bregante MA,Garcia MA,Perez S

更新日期：2004-06-01 00:00:00

abstract：:Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem) to quinolones, such as norfloxacin and fleroxacin, chloramphenicol ...

journal_title：Chemotherapy

authors： Leying HJ,Büscher KH,Cullmann W,Then RL

更新日期：1992-01-01 00:00:00

abstract：:One hundred symptomatic women with clinical bacterial vaginosis (BV) were enrolled in this study. The bacteriological epidemiology of BV and efficacy of oral or vaginal administration of antimicrobial agents for treatment of BV were investigated. The epidemiology of BV was investigated before antimicrobial therapy. Fi...

journal_title：Chemotherapy

authors： Mikamo H,Kawazoe K,Izumi K,Ito K,Katoh N,Watanabe K,Ueno K,Tamaya T

更新日期：1996-01-01 00:00:00

abstract：:Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...

journal_title：Chemotherapy

authors： Rolston K,Alvarez ME,Hoy JF,LeBlanc B,Ho DH,Bodey GP

更新日期：1986-01-01 00:00:00

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00