Investigation of the anti-HIV properties of oxihumate.

abstract：BACKGROUND:Bacterial endotoxin is known to act as a potent trigger of disseminated coagulation and septic shock. During clinical antibiotic treatment, endotoxin may be released from Gram-negative bacteria. It is known that antibiotic classes differ in their ability to induce endotoxin release. AIM:It was the aim of th...

journal_title：Chemotherapy

authors： Trautmann M,Scheibe C,Wellinghausen N,Holst O,Lepper PM

更新日期：2010-01-01 00:00:00

abstract：:Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...

journal_title：Chemotherapy

authors： Bousquet C,Puente E,Buscail L,Vaysse N,Susini C

更新日期：2001-01-01 00:00:00

abstract：:17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...

journal_title：Chemotherapy

authors： Focht J,Klietmann W,Nösner K,Rolinson GN,Johnsen J

更新日期：1988-01-01 00:00:00

abstract：:We report here the antibacterial activity of the new penem antibiotic Men 10700 against a total of 740 gram-positive and gram-negative clinical isolates, in comparison to imipenem, meropenem, cefotaxime, ceftriaxone, ciprofloxacin and gentamicin. Men 10700 has shown a wide spectrum of antibacterial activity, with a po...

journal_title：Chemotherapy

authors： Varotto F,Parravidini E,De Luca M,Casini A,Fraschini F

更新日期：1999-11-01 00:00:00

abstract：:The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,...

journal_title：Chemotherapy

authors： Maderazo EG,Breaux SP,Woronick CL,Quintiliani R,Nightingale CH

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS:We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate esc...

journal_title：Chemotherapy

authors： Ratanajarusiri T,Sriuranpong V,Sitthideatphaiboon P,Poovoravan N,Vinayanuwat C,Parinyanitikul N,Angspatt P,Thawinwisan W,Tanasanvimon S

更新日期：2017-01-01 00:00:00

abstract：:The post-antibiotic effects (PAEs) of a new cephalosporin, cefdinir, were determined against a range of organisms using a viable counting technique. Cefdinir exerted considerable PAEs against Staphylococcus aureus and Streptococcus pyogenes, but no overall post-antibiotic inhibition of growth was detected against Esch...

journal_title：Chemotherapy

authors： Howard BM,Pinney RJ,Smith JT

更新日期：1994-07-01 00:00:00

abstract：:The minimum inhibitory concentration (MIC) of the new penem ALP 201 was tested against 243 recent clinical isolates of which 95 were from the family Enterobacteriaceae, 50 were from the genus Streptococcus, 50 were Staphylococcus aureus and 48 were Staphylococcus epidermidis. An agar dilution technique was used to det...

journal_title：Chemotherapy

authors： Bergan T,da Fonseca J

更新日期：1991-01-01 00:00:00

abstract：:Cardiovascular (CV) adverse events are considered common complications of ponatinib treatment. Recently, it has been demonstrated that ponatinib dose reductions in definite settings can obtain optimal responses and lower ponatinib-related CV events. In this study, we describe the management of 5 patients with chronic ...

journal_title：Chemotherapy

authors： Santoro M,Accurso V,Mancuso S,Contrino AD,Sardo M,Novo G,Di Piazza F,Perez A,Russo A,Siragusa S

更新日期：2019-01-01 00:00:00

abstract：:The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...

journal_title：Chemotherapy

authors： Liss RH,Norman JC

更新日期：1975-01-01 00:00:00

abstract：:Lower respiratory tract infections are the major cause of death due to infectious disease in the developed and developing world. Despite substantial progress in defining pathogens and in therapeutic options, there continues to be major controversies in the clinical management of these infections. This report reviews t...

journal_title：Chemotherapy

authors： Bartlett J

更新日期：2000-01-01 00:00:00

abstract：:Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...

journal_title：Chemotherapy

authors： Saijo Y,Nakai Y,Saito J,Sugawara S,Suzuki S,Numata Y,Motomiya M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...

journal_title：Chemotherapy

authors： Pohlen U,Binnenhei M,Reszka R,Buhr HJ,Berger G

更新日期：2004-06-01 00:00:00

abstract：:Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents w...

journal_title：Chemotherapy

authors： Jimbow T,Tejima Y,Ikemoto H

更新日期：1978-01-01 00:00:00

abstract：:Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...

journal_title：Chemotherapy

authors： Denning DW,Donnelly JP,Hellreigel KP,Ito J,Martino P,van't Wout JW

更新日期：1992-01-01 00:00:00

abstract：:The sensitivity of 23 isolates of opportunistic fungi, Aspergillus fumigatus (5), A. flavus (5), A. niger (5), Pseudallescheria boydii (5), Alternaria alternata (2) and Xylohypha bantiana (1), was investigated against fluconazole and itraconazole, using Sabouraud's dextrose broth (SD) and a high-resolution (HR) medium...

journal_title：Chemotherapy

authors： Sekhon AS,Padhye AA,Garg AK,Hamir Z

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:A single-institution phase I trial to determine the feasibility of using filgrastim or pegfilgrastim to increase the dose intensity of biweekly docetaxel and gemcitabine. METHODS:Patients with metastatic solid tumors received gemcitabine 3,000 mg/m(2) and increasing doses of docetaxel (55 mg/m(2) in 10...

journal_title：Chemotherapy

authors： Dragnev KH,Hardin SB,Pipas JM,Davis TH,Rigas JR

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality. TREATMENT:First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-l...

journal_title：Chemotherapy

authors： McLoughlin R,O'Morain C

更新日期：2005-08-01 00:00:00

abstract：:100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...

journal_title：Chemotherapy

authors： Blanc C,Pollet JP,Bauters F

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...

journal_title：Chemotherapy

authors： Roveta S,Marchese A,Debbia EA

更新日期：2008-01-01 00:00:00

abstract：:A narcissus alkaloid, pretazettine hydrochloride (PTZ), has been shown to be active against Ehrlich ascites carcinoma. The Ehrlich cells are more sensitive to PTZ in DBA/2 mice than in Swiss mice. The therapeutic activity of the individual standard drugs in ABC (adriamycin, BCNU, and cyclophosphamide) regimen against ...

journal_title：Chemotherapy

authors： Furusawa E,Lum MK,Furusawa S

更新日期：1981-01-01 00:00:00

abstract：:A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...

journal_title：Chemotherapy

authors： Kissling M,Bergamini N

更新日期：1981-01-01 00:00:00

abstract：:The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted i...

journal_title：Chemotherapy

authors： Mally MB,Taylor RC,Callewaert DM

更新日期：1980-01-01 00:00:00

abstract：:The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fler...

journal_title：Chemotherapy

authors： Hupertz V,Carr H,Czinn SJ

更新日期：1988-01-01 00:00:00

abstract：:In this paper the bactericidal activities of ofloxacin and its optically active derivative, DR-3355, against non-growing cells of Escherichia coli and Pseudomonas aeruginosa are described. E. coli and P. aeruginosa were killed rapidly by ofloxacin and DR-3355. After treatment with these quinolones, the resting cells o...

journal_title：Chemotherapy

authors： Tanaka M,Otsuki M,Nishino T

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Dosage recommendations for antibiotics in patients receiving continuous veno-venous hemofiltration (CVVH) should be based on pharmacodynamic requirements. For meropenem, this would be achieving appropriate time above the minimum inhibitory concentration (T > MIC). We employed Monte Carlo simulation to calcul...

journal_title：Chemotherapy

authors： Kuti JL,Nicolau DP

更新日期：2005-07-01 00:00:00

abstract：:The antimicrobial susceptibility and in vitro growth curve of 4 nonencapsulated and 4 encapsulated isolates of Bacteroides fragilis were determined for clindamycin. The MIC of the nonencapsulated isolates was 1-2 dilutions less (0.062-0.25 microgram/ml) than the MIC for their encapsulated counterparts (0.25-0.5 microg...

journal_title：Chemotherapy

authors： Brook I,Gillmore JD

更新日期：1994-01-01 00:00:00

abstract：:Differences in the pharmacokinetic parameters of cephalosporins between children and adults may be predictable on the basis of the level of maturation of the physiologic processes involved in drug disposition. It appears that the most important of these factors (gastrointestinal, renal and hepatic function) are reason...

journal_title：Chemotherapy

authors： Edwards DJ,Stoeckel K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...

journal_title：Chemotherapy

authors： Yasumatsu R,Nakashima T,Uryu H,Ayada T,Wakasaki T,Kogo R,Masuda M,Fukushima M,Komune S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00