Effectiveness of antiinfectives.

abstract：:We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...

journal_title：Chemotherapy

authors： Brown R

更新日期：1991-01-01 00:00:00

abstract：:The effect of deficiency of vitamin A and its supplementation on growth of murine sarcoma 180 was evaluated. The efficacy of cyclophosphamide under depleted and supplemented condition of the vitamin was also scrutinized. Supplemental vitamin A helped to check progression of tumour growth and also increased the effecti...

journal_title：Chemotherapy

authors： Ghosh J,Das S

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Brucellosis is one of the important health problems for both humans and animals in Turkey since agriculture and stock raising appears to be the most important means of subsistence. Investigations on the pathogenesis of brucellosis reveal that the etiologic agent can survive in phagocytic cells, and cell-medi...

journal_title：Chemotherapy

authors： Dizer U,Hayat L,Beker CM,Görenek L,Ozgüven V,Pahsa A

更新日期：2005-03-01 00:00:00

abstract：:Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...

journal_title：Chemotherapy

authors： Korting HC,Niederauer H,Ollert M

更新日期：1986-01-01 00:00:00

abstract：:Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem) to quinolones, such as norfloxacin and fleroxacin, chloramphenicol ...

journal_title：Chemotherapy

authors： Leying HJ,Büscher KH,Cullmann W,Then RL

更新日期：1992-01-01 00:00:00

abstract：:This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/d...

journal_title：Chemotherapy

authors： Furuhama K,Benson RW,Knowles BJ,Roberts DW

更新日期：1993-07-01 00:00:00

abstract：:Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...

journal_title：Chemotherapy

authors： Laferriere C,Stutman HR,Marks MI,Kramer J,Flux M

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:We evaluated the effectiveness of docetaxel or erlotinib in second-line treatment of non-small cell lung cancer (NSCLC) and focused on the impact of predictive factors on the outcome of therapy. METHODS:204 patients with progressive disease after platinum-based therapy were enrolled: 102 received an infusio...

journal_title：Chemotherapy

authors： Krawczyk P,Kowalski DM,Wojas-Krawczyk K,Mlak R,Jaśkiewicz P,Kucharczyk T,Winiarczyk K,Krzakowski M,Milanowski J

更新日期：2012-01-01 00:00:00

abstract：:Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...

journal_title：Chemotherapy

authors： Hori K

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Recently, multiple-line chemotherapy has become popular for non-small cell lung cancer (NSCLC). The survival time of patients is influenced by patient characteristics and subsequent treatments. METHODS:The usefulness of paclitaxel plus S1 (PTX+S1) was evaluated in 46 pretreated NSCLC patients. Time from the...

journal_title：Chemotherapy

authors： Aono N,Ito Y,Nishino K,Uchida J,Kumagai T,Akazawa Y,Okuyama T,Yoshinami T,Imamura F

更新日期：2012-01-01 00:00:00

abstract：:The study of resistance patterns of strains of bacteria to antibiotics in different regions of a country and, if possible, comparing them at international level appears to be a useful exercise. The patterns of resistance during 1968-71 revealed an increasing resistance for most antibiotics with an unexpected increase ...

journal_title：Chemotherapy

authors： Driessen JH

更新日期：1975-01-01 00:00:00

abstract：:The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...

journal_title：Chemotherapy

authors： Rees RC,Potter CW,Clegg A,Hall JM

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Considering the potentials of gatifloxacin and moxifloxacin in the treatment of tuberculosis, the present study was aimed to define resistance to both these drugs. METHODS:Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofloxacin-susceptible and 20 ofloxacin-resistant strains, were tested for th...

journal_title：Chemotherapy

authors： Somasundaram S,Paramasivan NC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Cisplatin (CDDP) is known to cause inner ear damage while carboplatin (CBDCA) induces less ototoxicity than CDDP. We examined apoptotic changes in the cochlea of guinea pigs after injection of CDDP or CBDCA using immunohistochemical and electrophysiological techniques. METHODS:Three days after the injection...

journal_title：Chemotherapy

authors： Watanabe KC,Jinnouchi K,Hess A,Michel O,Baba S,Yagi T

更新日期：2002-05-01 00:00:00

abstract：:Studies are presented on the in vitro phagocytic activity of rat and human polymorphonuclear leukocytes exposed in vivo to therapeutic concentrations of doxycycline. A 32P-labelled strain of Escherichia coli served as test microbe. No significant reduction of ingestion was observed although untreated AB leukocytes tes...

journal_title：Chemotherapy

authors： Melby K,Midtvedt T

更新日期：1981-01-01 00:00:00

abstract：:The binding of five structurally diverse beta-lactam antibiotics to penicillin-binding proteins (PBPs) of two clinical isolates of Streptococcus pneumoniae resistant to penicillin G was compared with that of a susceptible strain. A common feature of the PBP patterns of the resistant strains was the absence of PBP 1a d...

journal_title：Chemotherapy

authors： Ikeda F,Yokota Y,Ikemoto A,Teratani N,Shimomura K,Kanno H

更新日期：1995-05-01 00:00:00

abstract：:The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Result...

journal_title：Chemotherapy

authors： Gordon RC,Tack KJ,Haddy RI,Fechner L,Wofford R

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...

journal_title：Chemotherapy

authors： Rapoport BL,Uys A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Ceftazidime is a third-generation cephalosporin almost entirely eliminated by glomerular filtration and dose reductions are essential in patients with renal impairment. The physicochemical and pharmacokinetic properties of ceftazidime make it susceptible to be eliminated by continuous renal replacement thera...

journal_title：Chemotherapy

authors： Isla A,Gascón AR,Maynar J,Arzuaga A,Sánchez-Izquierdo JA,Pedraz JL

更新日期：2007-01-01 00:00:00

abstract：:Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. METHODS:We examined the effect of DHE on the surviva...

journal_title：Chemotherapy

authors： Chang SH,Lee AY,Yu KN,Park J,Kim KP,Cho MH

更新日期：2016-01-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：:Differences in the pharmacokinetic parameters of cephalosporins between children and adults may be predictable on the basis of the level of maturation of the physiologic processes involved in drug disposition. It appears that the most important of these factors (gastrointestinal, renal and hepatic function) are reason...

journal_title：Chemotherapy

authors： Edwards DJ,Stoeckel K

更新日期：1992-01-01 00:00:00

abstract：:The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...

journal_title：Chemotherapy

authors： Dos Santos C,Capelo A,Cimbro M,Ferrara A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS:Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal t...

journal_title：Chemotherapy

authors： Szilágyi J,Földi R,Gesztelyi R,Bayegan S,Kardos G,Juhász B,Majoros L

更新日期：2012-01-01 00:00:00

abstract：:This investigation used the postantibiotic effect (PAE) and killing curves to provide data on the antimicrobial activity of subinhibitory (1/8x, 1/4x and 1/2x minimum inhibitory concentration; MIC) and inhibitory (1x MIC) concentrations of amikacin, gentamicin and tobramycin against Pseudomonas aeruginosa. Subinhibito...

journal_title：Chemotherapy

authors： Zhanel GG,Karlowsky JA,Hoban DJ,Davidson RJ

更新日期：1991-01-01 00:00:00

abstract：:The two studies which are reviewed in this paper demonstrate the value of fluorescent microscopic observations in the studying of the distribution of antibiotics in lung tissue and in sinus secretions. In the lung tissue study, the standard microbiologic assay data on doxycycline concentrations in respiratory tissue t...

journal_title：Chemotherapy

authors： Liss RH,Norman JC

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00

abstract：:The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Pro...

journal_title：Chemotherapy

authors： Schmid EN

更新日期：1984-01-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...

journal_title：Chemotherapy

authors： Mese H,Sasaki A,Alcalde RE,Nakayama S,Matsumura T

更新日期：2000-01-01 00:00:00