Abstract:
BACKGROUND:Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. METHODS:We examined the effect of DHE on the survival of several lung cancer cells and confirmed that DHE suppressed diverse lung cancer cell growth effectively. To confirm whether such effects of DHE would be associated with mitochondria, A549 cells were employed for the evaluation of several important parameters, such as membrane potential, reactive oxygen species (ROS) generation, apoptosis, ATP production and autophagy. RESULTS:DHE decreased membrane permeability, increased ROS generation as well as apoptosis, and disturbed ATP production. Eventually, mitophagy was activated for damaged mitochondria. CONCLUSION:Taken together, our findings demonstrate that DHE induces lung cancer cell death by the induction of apoptosis and mitophagy, thus suggesting that DHE can be developed as an anti-lung cancer therapeutic agent.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Chang SH,Lee AY,Yu KN,Park J,Kim KP,Cho MHdoi
10.1159/000445044subject
Has Abstractpub_date
2016-01-01 00:00:00pages
304-12issue
6eissn
0009-3157issn
1421-9794pii
000445044journal_volume
61pub_type
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