Abstract:
:The effect of low concentrations of various antimicrobial agents on the adherence of mucoid Staphylococcus epidermidis to intraocular lenses was investigated. Adherent growth of S. epidermidis on to polymethylmethacrylate lenses was greatly diminished by ciprofloxacin and clindamycin (>75%), followed by ceftazidime ( approximately 50%) and less affected by gentamicin and vancomycin (<25%) compared to the adherent growth of control untreated cells. The reduction in adherence growth was concentration-dependent and found to be due to the inhibition of slime production since no growth inhibition was observed at the concentrations used. Cell surface hydrophobicity was markedly reduced in parallel to the inhibition of adherence as compared to the control cells. The differential effect of antibiotics on adherence, regardless of their antimicrobial activity, may have a clinical significance in reducing the incidence of postoperative endophthalmitis and intraocular inflammation due to the reduction of cell adherence.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Kadry AA,Tawfik A,Abu El-Asrar AA,Shibl AMdoi
10.1159/000007165subject
Has Abstractpub_date
1999-01-01 00:00:00pages
56-60issue
1eissn
0009-3157issn
1421-9794pii
che45056journal_volume
45pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000088961
更新日期:2005-10-01 00:00:00
abstract::The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238342
更新日期:1985-01-01 00:00:00
abstract::The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007273
更新日期:2000-05-01 00:00:00
abstract::The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods compared to results obtained with the combination of imipenem with amikacin. Synergistic antibacterial action (defined as FIC index less than or equal to 0.5) w...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238558
更新日期:1988-01-01 00:00:00
abstract::The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238091
更新日期:1982-01-01 00:00:00
abstract::The minimum inhibitory concentration (MIC) of the new penem ALP 201 was tested against 243 recent clinical isolates of which 95 were from the family Enterobacteriaceae, 50 were from the genus Streptococcus, 50 were Staphylococcus aureus and 48 were Staphylococcus epidermidis. An agar dilution technique was used to det...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238888
更新日期:1991-01-01 00:00:00
abstract::The concentrations of clarithromycin after a single oral dose of 500 mg were determined in serum and saliva of ten healthy adult volunteers. After 2 h, the levels were 4.04 +/- 1.14 (SD) mg/l in serum and 2.72 +/- 0.87 mg/l in saliva. After 7 h these values were 1.98 +/- 0.65 and 1.21 +/- 0.34 mg/l, respectively, and ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239139
更新日期:1993-09-01 00:00:00
abstract::Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238704
更新日期:1989-01-01 00:00:00
abstract::Concentrations of latamoxef, cefoperazone and piperacillin, administered intravenously, were measured in serum and sputum of cystic fibrosis patients with recurrent pulmonary infections, chronically colonized with Pseudomonas aeruginosa. Serum pharmacokinetic data were consistent with prior reports. Peak sputum to pea...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238344
更新日期:1985-01-01 00:00:00
abstract::The in vitro antimicrobial activities of AM-1155, a new fluoroquinolone, tosufloxacin and fleroxacin were tested against 55 clinical isolates of Neisseria gonorrhoeae using the agar dilution method. In our previous study, all the strains had been examined for mutations in the region corresponding to the quinolone-resi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239573
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000095960
更新日期:2006-01-01 00:00:00
abstract::Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239014
更新日期:1992-01-01 00:00:00
abstract::BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238470
更新日期:1987-01-01 00:00:00
abstract::A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237887
更新日期:1980-01-01 00:00:00
abstract::The mode of action of 5-fluorocytosine (5-FC) was studied in three isolates of pathogenic Aspergillus with varying degrees of susceptibility to the drug. Distribution studies showed that susceptibility or resistance to 5-FC was not dependent on uptake of the drug. While only a small percentage of the total 5-FC taken ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237824
更新日期:1979-01-01 00:00:00
abstract::Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem) to quinolones, such as norfloxacin and fleroxacin, chloramphenicol ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238946
更新日期:1992-01-01 00:00:00
abstract::Two groups of patients suffering surgical infections were treated with fosfomycin. The first includes 21 suppurating dermic of soft underlying tissue lesions. The second group includes 29 surgical abdominal infections. The bacteriology of the first group was made up of gram-positive and gram-negative germs predominant...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222080
更新日期:1977-01-01 00:00:00
abstract::Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007258
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. CASE REPORT:We report 3 cases of pulmonary adenocarcinoma which did not respond to EGFR-TKI retreatment even with T790M disappearance...
journal_title:Chemotherapy
pub_type:
doi:10.1159/000491937
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000351101
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000335588
更新日期:2011-01-01 00:00:00
abstract::Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238297
更新日期:1984-01-01 00:00:00
abstract::An in vitro infection model was created using a suspension of macrophages, polymorphonuclear leukocytes, lymphocytes, fibroblasts, and human serum to which pathogen and antibiotic were added. Separate intracellular and extracellular antibiotic concentrations and activity against Staphylococcus aureus and Legionella pn...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238987
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000175465
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323629
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. METHODS:We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate esc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000450748
更新日期:2017-01-01 00:00:00
abstract::Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been reported to have a hig...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007115
更新日期:1998-05-01 00:00:00
abstract::Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum be...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239445
更新日期:1996-05-01 00:00:00
abstract::A single oral dose of an antimicrobial agent is as effective as a conventional 3-day course for the treatment of uncomplicated lower urinary tract infections. A case history of a young woman with recurrent cystitis is presented to demonstrate this approach to the management of a common clinical problem. The place of a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239487
更新日期:1996-03-01 00:00:00
abstract::The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048498
更新日期:2001-01-01 00:00:00