Abstract：
:An in vitro infection model was created using a suspension of macrophages, polymorphonuclear leukocytes, lymphocytes, fibroblasts, and human serum to which pathogen and antibiotic were added. Separate intracellular and extracellular antibiotic concentrations and activity against Staphylococcus aureus and Legionella pneumophila were assessed for three antimicrobial agents: amoxicillin, azithromycin and clarithromycin. Amoxicillin was found almost exclusively in extracellular fluid, where it was active; intracellularly, it was ineffective. Azithromycin, in contrast, was primarily concentrated and active intracellularly, with little activity in extracellular fluid. Clarithromycin was present in both compartments and possessed significant activity both intracellularly and extracellularly.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Scaglione F,Demartini G,Dugnani S,Fraschini Fdoi
10.1159/000238987subject
Has Abstractpub_date
1993-11-01 00:00:00pages
416-23issue
6eissn
0009-3157issn
1421-9794journal_volume
39pub_type
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