Abstract:
:Ocular penetration of grepafloxacin into several ocular tissues was determined in albino and pigmented rabbits following a single intravitreal administration. After administration, grepafloxacin was detected in all ocular tissues studied in both breeds of rabbits. The superior mean penetration ratios were found in the chorioretina and lens of albino rabbits, and in the chorioretina, iris and lens of pigmented rabbits. A significantly greater penetration of grepafloxacin was found in the chorioretina and iris of the pigmented rabbits than in those of the albino rabbits. As a final conclusion, grepafloxacin detected in different ocular structures could attain therapeutic concentrations against a variety of ocular conditions.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Solans C,Bregante MA,Garcia MA,Perez Sdoi
10.1159/000077887subject
Has Abstractpub_date
2004-06-01 00:00:00pages
133-7issue
3eissn
0009-3157issn
1421-9794pii
77887journal_volume
50pub_type
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