Analytical studies on beta-lactam antibiotics. II. Displacement effect of beta-lactam antibiotics on bilirubin bound to human serum albumin.

Abstract:

:We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determined by Brodersen's method. The KD values of latamoxef reported by many investigators based on Brodersen's method were higher than the true value owing to interaction of the drug with peroxidase and H2O2. Our KD value under the new enzyme conditions was 2.6 X 10(3). Little or no interaction of drug with the enzyme system was tentatively confirmed. Flomoxef, a newly developed drug, and 7432-S, under development in our company, had KD values of 0.4 X 10(3) and 2.8 X 10(3), respectively.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Matsuura A,Nagayama T,Kitagawa T

doi

10.1159/000238590

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

345-53

issue

4

eissn

0009-3157

issn

1421-9794

journal_volume

34

pub_type

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