Abstract:
:We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determined by Brodersen's method. The KD values of latamoxef reported by many investigators based on Brodersen's method were higher than the true value owing to interaction of the drug with peroxidase and H2O2. Our KD value under the new enzyme conditions was 2.6 X 10(3). Little or no interaction of drug with the enzyme system was tentatively confirmed. Flomoxef, a newly developed drug, and 7432-S, under development in our company, had KD values of 0.4 X 10(3) and 2.8 X 10(3), respectively.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Matsuura A,Nagayama T,Kitagawa Tdoi
10.1159/000238590subject
Has Abstractpub_date
1988-01-01 00:00:00pages
345-53issue
4eissn
0009-3157issn
1421-9794journal_volume
34pub_type
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