Comparison of intraperitoneal with intravenous administration of taxol in experimental peritoneal carcinomatosis.

abstract：BACKGROUND:The efficacy of fluconazole (FLU), amphotericin B (AMB) and caspofungin (CAS) was tested against three Candida orthopsilosis, three C. metapsilosis and two C. parapsilosis sensu stricto isolates in neutropenic mice. METHODS:Mice were immunosuppressed by 200 mg/kg cyclophosphamide. Five-day intraperitoneal t...

journal_title：Chemotherapy

authors： Szilágyi J,Földi R,Gesztelyi R,Bayegan S,Kardos G,Juhász B,Majoros L

更新日期：2012-01-01 00:00:00

abstract：:We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6-10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10-14 days and therapeutical succ...

journal_title：Chemotherapy

authors： Lus RG,Calvo MC,Lopez LG,Cancer RC,Molina AM,Sanchez ED,Parilla AC,Mur LL

更新日期：1977-01-01 00:00:00

abstract：:In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...

journal_title：Chemotherapy

authors： Winkler D,Rehn H,Freckmann N,Nowak G,Herrmann HD

更新日期：1989-01-01 00:00:00

abstract：:This study was performed in female B6C3F1 mice to confirm previously observed effects of selected cephalosporin antibiotics on nonspecific immunity, and to determine possible effects on specific acquired immunity and host resistance. Mice were treated intravenously with DQ-2556, ceftizoxime or ceftezole at 800 mg/kg/d...

journal_title：Chemotherapy

authors： Furuhama K,Benson RW,Knowles BJ,Roberts DW

更新日期：1993-07-01 00:00:00

abstract：:The in vitro activity of sparfloxacin, a new fluoroquinolone, was compared with ciprofloxacin and ofloxacin against 166 consecutive isolates from the upper respiratory tract of outpatients. The strains were fully susceptible to three quinolones. The antibacterial activity of sparfloxacin was comparable or better than ...

journal_title：Chemotherapy

authors： Malmborg AS,Ahlén S

更新日期：1993-01-01 00:00:00

abstract：:The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Result...

journal_title：Chemotherapy

authors： Gordon RC,Tack KJ,Haddy RI,Fechner L,Wofford R

更新日期：1984-01-01 00:00:00

abstract：:Enterococcus faecalis plays an important role as a pathogen in polymicrobial infections. We evaluated the efficacy of cefozopran (CZOP) using polymicrobial pyometra rats. Rats were infected with a mixed intrauterine inoculation of E. faecalis plus either Bacteroides fragilis or Prevotella bivia (minimal inhibitory con...

journal_title：Chemotherapy

authors： Mikamo H,Kawazoe K,Sato Y,Izumi K,Tamaya T

更新日期：1998-03-01 00:00:00

abstract：:A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...

journal_title：Chemotherapy

authors： van Rensburg CE,Dekker J,Weis R,Smith TL,Janse van Rensburg E,Schneider J

更新日期：2002-07-01 00:00:00

abstract：:Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized ...

journal_title：Chemotherapy

authors： Maraki S,Barbounakis E,Chatzinikolaou I,Anatoliotakis N,Plataki M,Tselentis Y,Samonis G

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...

journal_title：Chemotherapy

authors： Shin BS,Bulitta JB,Hong DK,Kim HY,Kim MK,Choi Y,Lee JB,Hwang SW,Lee MH,Yoo SD

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...

journal_title：Chemotherapy

authors： Wei Y,Liu J,Yan M,Zhao S,Long Y,Zhang W

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：:We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...

journal_title：Chemotherapy

authors： Brown R

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...

journal_title：Chemotherapy

authors： Bozkurt-Guzel C,Savage PB,Gerceker AA

更新日期：2011-01-01 00:00:00

abstract：:One hundred symptomatic women with clinical bacterial vaginosis (BV) were enrolled in this study. The bacteriological epidemiology of BV and efficacy of oral or vaginal administration of antimicrobial agents for treatment of BV were investigated. The epidemiology of BV was investigated before antimicrobial therapy. Fi...

journal_title：Chemotherapy

authors： Mikamo H,Kawazoe K,Izumi K,Ito K,Katoh N,Watanabe K,Ueno K,Tamaya T

更新日期：1996-01-01 00:00:00

abstract：:The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37 degrees C) of PMN with different concentrations of linezolid (2, 10 and 20 mg/l) did not significantly affect the phagocytosis of either...

journal_title：Chemotherapy

authors： Ballesta S,Pascual A,García I,Perea EJ

更新日期：2003-07-01 00:00:00

abstract：:Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1994-01-01 00:00:00

abstract：:This investigation used the postantibiotic effect (PAE) and killing curves to provide data on the antimicrobial activity of subinhibitory (1/8x, 1/4x and 1/2x minimum inhibitory concentration; MIC) and inhibitory (1x MIC) concentrations of amikacin, gentamicin and tobramycin against Pseudomonas aeruginosa. Subinhibito...

journal_title：Chemotherapy

authors： Zhanel GG,Karlowsky JA,Hoban DJ,Davidson RJ

更新日期：1991-01-01 00:00:00

abstract：:The elimination of para-aminosalicylic acid (PAS) after the intravenous injection of 20 mg PAS sodium/kg was estimated in patients with liver disease, in uremic patients and in volunteers without damage of the liver or kidneys. The drug was estimated with a colorimetric and fluorometric method. In the volunteers, the ...

journal_title：Chemotherapy

authors： Held H,Fried F

更新日期：1977-01-01 00:00:00

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND/AIM:A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and ...

journal_title：Chemotherapy

authors： Nagase H,Nakagawa F,Uchida J

更新日期：2018-01-01 00:00:00

abstract：:Aggressive non-Hodgkin lymphoma is associated with poor long-term survival after relapse or resistance to chemotherapy. We report a case of aggressive non-Hodgkin lymphoma refractory to first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and second-line R-DHAP (rituximab, dexameth...

journal_title：Chemotherapy

authors： Appio L,Landoni C,La Targia M,Bertolli V,Chiarucci M,Crovetti G,Vassenna E,Serio G,Bregni M

更新日期：2017-01-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：:A group of cis-ethylenediammine platinum (II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it bi...

journal_title：Chemotherapy

authors： Chakraborty BK,Biswas N,Choudhury K,Neogy RK,Das Sarma B

更新日期：1985-01-01 00:00:00

abstract：:After intravenous bolus injection of single doses of 25, 50, 75 and 100 mg of ofloxacin (HOE 280) to 34 healthy male volunteers, concentrations of unchanged drug were estimated at various times in serum and urine over 32 and 48 h. Ofloxacin concentrations were determined using high-pressure liquid chromatography (HPLC...

journal_title：Chemotherapy

authors： Verho M,Korn A,Badian M,Malerczyk V,Waldhäusl W

更新日期：1988-01-01 00:00:00

abstract：:The activity of aztreonam (a beta-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative pathogens, either alone or in association with other bacteria. Of a total st...

journal_title：Chemotherapy

authors： Birolini D,Moraes MF,de Souza OS

更新日期：1989-01-01 00:00:00

abstract：:The intraphagocytic killing of Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, and Salmonella typhi by ciprofloxacin (0.1, 1 and 5 microg/ml) within human neutrophils with intact and impaired (by phenylbutazone treatment) O2-dependent killing mechanisms was studied and compared with the extracellular ki...

journal_title：Chemotherapy

authors： Cantón E,Peman J,Cabrera E,Velert M,Orero A,Pastor A,Gobernado M

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...

journal_title：Chemotherapy

authors： Guiral E,Bosch J,Vila J,Soto SM

更新日期：2012-01-01 00:00:00

abstract：:Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml afte...

journal_title：Chemotherapy

authors： Gilfillan EC,Pelak BA,Bland JA,Malatesta PF,Gadebusch HH

更新日期：1984-01-01 00:00:00

abstract：:Malignant external otitis is a serious infection most frequently caused by Pseudomonas aeruginosa. Because of its antipseudomonal activity and good tissue penetration, ciprofloxacin is an antibiotic which should, in theory, be effective in the treatment of this type of infection. Publications on the use of ciprofloxac...

journal_title：Chemotherapy

authors： Gehanno P

更新日期：1994-01-01 00:00:00