Abstract:
:Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml after an oral drug dose of 25 mg/kg of animal body weight and were similar to those in mice. Serum half-life of norfloxacin in rodents and monkeys was similar to that in humans. Concentrations of norfloxacin in tissues of mice, rats and monkeys were greater than those in serum suggesting a large volume of distribution for the drug.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Gilfillan EC,Pelak BA,Bland JA,Malatesta PF,Gadebusch HHdoi
10.1159/000238283subject
Has Abstractpub_date
1984-01-01 00:00:00pages
288-96issue
5eissn
0009-3157issn
1421-9794journal_volume
30pub_type
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