Surgical suppurating infections and surgical abdominal infections treated with fosfomycin.

abstract：:The involvement of plasma testosterone in patients associated with scalp hair loss accelerated by anticancer drugs including aclarubicin and cisplatin was investigated. Scalp hair loss observed was minor in 12 and severe in 2 out of 31 patients. In patients without significant hair loss, the combination of aclarubicin...

journal_title：Chemotherapy

authors： Umeki S,Niki Y,Soejima R

更新日期：1989-01-01 00:00:00

abstract：:Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluoroura...

journal_title：Chemotherapy

authors： Furusawa E,Furusawa E,Sokugawa L

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Mutant prevention concentration (MPC) is a new parameter that may be of aid in determining the risk of resistant mutants being selected. METHODS:The MPCs of 224 Mycobacterium tuberculosis clinical isolates were estimated by plating more than 10(10) cells on drug-containing agar and determining the concentra...

journal_title：Chemotherapy

authors： Rodríguez JC,Cebrián L,Ruiz M,López M,Royo G

更新日期：2005-05-01 00:00:00

abstract：:Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...

journal_title：Chemotherapy

authors： Yourassowsky E,Van der Linden MP,Crokaert F

更新日期：1989-01-01 00:00:00

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...

journal_title：Chemotherapy

authors： Benoit-Vical F,Grellier P,Abdoulaye A,Moussa I,Ousmane A,Berry A,Ikhiri K,Poupat C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...

journal_title：Chemotherapy

authors： Rapoport BL,Uys A

更新日期：2008-01-01 00:00:00

abstract：:A narcissus alkaloid, pretazettine hydrochloride (PTZ), has been shown to be active against Ehrlich ascites carcinoma. The Ehrlich cells are more sensitive to PTZ in DBA/2 mice than in Swiss mice. The therapeutic activity of the individual standard drugs in ABC (adriamycin, BCNU, and cyclophosphamide) regimen against ...

journal_title：Chemotherapy

authors： Furusawa E,Lum MK,Furusawa S

更新日期：1981-01-01 00:00:00

abstract：:Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopo...

journal_title：Chemotherapy

authors： Wong CK,Fung KP,Kong SK,Lee CY,Choy YM

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00

abstract：:The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The para...

journal_title：Chemotherapy

authors： Meldrum JB,Gupta VS,Babiuk LA

更新日期：1980-01-01 00:00:00

abstract：:Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...

journal_title：Chemotherapy

authors： Denning DW,Donnelly JP,Hellreigel KP,Ito J,Martino P,van't Wout JW

更新日期：1992-01-01 00:00:00

abstract：:A total of 5 healthy volunteers were enrolled in a crossover study on the dose dependency and the effect of probenecid on pharmacokinetics of DQ-2556. They were administered intravenously 0.5 and 1.0 g of DQ-2556, and 1.0 g of DQ-2556 with oral administration of probenecid. The linearity in pharmacokinetics of DQ-2556...

journal_title：Chemotherapy

authors： Shiba K,Yoshida M,Shimada J,Saito A,Matsubayashi K,Hashimoto S,Yoshida K,Osada Y,Sakai O

更新日期：1992-01-01 00:00:00

abstract：:Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents w...

journal_title：Chemotherapy

authors： Jimbow T,Tejima Y,Ikemoto H

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Transplant-related mortality (TRM) significantly decreases the long-term survival of patients with hematopoietic diseases who undergo hematopoietic stem cell transplantation (HSCT). METHODS:We retrospectively evaluated the risk factors for TRM of 58 consecutive patients with hematopoietic disease who underw...

journal_title：Chemotherapy

authors： Nakamae H,Yamane T,Aoyama Y,Yamamura R,Ohta K,Hino M

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...

journal_title：Chemotherapy

authors： Hong A,Leigh BR

更新日期：2002-12-01 00:00:00

abstract：:In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...

journal_title：Chemotherapy

authors： Winkler D,Rehn H,Freckmann N,Nowak G,Herrmann HD

更新日期：1989-01-01 00:00:00

abstract：:21 patients, whose age ranged from 17 to 60 years and who had not been previously treated with antibiotics or other drugs, received bacampicillin as a perioperative prophylaxis for minor operations in the oral cavity. Four oral doses of bacampicillin were administered: each dose of 800 mg every 12 h, and the last dose...

journal_title：Chemotherapy

authors： del Piano M,Nicosia R,Sessa R,Grippaudo G,Lolli R,Monaco B

更新日期：1988-01-01 00:00:00

abstract：:Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...

journal_title：Chemotherapy

authors： Melloni D,Ammatuna P,Formica P,Falletta V,Gaglio F,Cacciatore M,Messina G

更新日期：1989-01-01 00:00:00

abstract：:100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...

journal_title：Chemotherapy

authors： Blanc C,Pollet JP,Bauters F

更新日期：1991-01-01 00:00:00

abstract：:The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...

journal_title：Chemotherapy

authors： Ling TK,Fung KS,Cheng AF

更新日期：2001-07-01 00:00:00

abstract：:Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not lik...

journal_title：Chemotherapy

authors： Ericsson CD,DuPont HL

更新日期：2005-01-01 00:00:00

abstract：:A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...

journal_title：Chemotherapy

authors： Lode H,Tomas W,Koeppe P,Wagner J

更新日期：1980-01-01 00:00:00

abstract：:Lower respiratory tract infections are the major cause of death due to infectious disease in the developed and developing world. Despite substantial progress in defining pathogens and in therapeutic options, there continues to be major controversies in the clinical management of these infections. This report reviews t...

journal_title：Chemotherapy

authors： Bartlett J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUNDS:The combination gemcitabine-oxaliplatin (GEMOX) is frequently used in patients with advanced biliary tract carcinoma (BTC). However, this is only based on phase II studies performed in selected patients.We assessed the efficacy and safety of the GEMOX regimen in non-selected patients with advanced BTC. MET...

journal_title：Chemotherapy

authors： Hollebecque A,Bouché O,Romano O,Scaglia E,Cattan S,Zerbib P,Heurgue A,Lagarde S,Mariette C,Triboulet JP,Pruvot FR,Hebbar M

更新日期：2010-01-01 00:00:00

abstract：:The in vitro activity of ceftazidime has been compared with those of cephalothin, cefuroxime, and netilmicin against a variety of gram-positive and gram-negative bacteria in order to register sensitivity patterns in the western part of Norway. An agar dilution method was used for minimal inhibitory concentration (MIC)...

journal_title：Chemotherapy

authors： Digranes A,Dibb WL,Benonisen E

更新日期：1984-01-01 00:00:00

abstract：:The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...

journal_title：Chemotherapy

authors： Pusztai-Markos Z,Pranada F,Leimbrock C

更新日期：1982-01-01 00:00:00

abstract：:We report here the antibacterial activity of the new penem antibiotic Men 10700 against a total of 740 gram-positive and gram-negative clinical isolates, in comparison to imipenem, meropenem, cefotaxime, ceftriaxone, ciprofloxacin and gentamicin. Men 10700 has shown a wide spectrum of antibacterial activity, with a po...

journal_title：Chemotherapy

authors： Varotto F,Parravidini E,De Luca M,Casini A,Fraschini F

更新日期：1999-11-01 00:00:00

abstract：:Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromato...

journal_title：Chemotherapy

authors： Viitanen J,Auvinen O,Tunturi T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:We evaluated the effectiveness of docetaxel or erlotinib in second-line treatment of non-small cell lung cancer (NSCLC) and focused on the impact of predictive factors on the outcome of therapy. METHODS:204 patients with progressive disease after platinum-based therapy were enrolled: 102 received an infusio...

journal_title：Chemotherapy

authors： Krawczyk P,Kowalski DM,Wojas-Krawczyk K,Mlak R,Jaśkiewicz P,Kucharczyk T,Winiarczyk K,Krzakowski M,Milanowski J

更新日期：2012-01-01 00:00:00