Changes in serum erythropoietin levels during chemotherapy for lung cancer.

Abstract:

:Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the patients were anemic. The increase of EPO levels was linearly related to the decrease in Hb (y = 17.48x + 1.003). The mechanism of the rapid increase of EPO is not simply explained by anemia, but might be related to new synthesis, corresponding to depressed bone marrow.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Saijo Y,Nakai Y,Saito J,Sugawara S,Suzuki S,Numata Y,Motomiya M

doi

10.1159/000239014

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

281-5

issue

5

eissn

0009-3157

issn

1421-9794

journal_volume

38

pub_type

杂志文章
  • Bioactivity of flurithromycin and other macrolides against intracellular susceptible staphylococci.

    abstract::The intracellular activity of flurithromycin, erythromycin, roxithromycin and miocamycin against susceptible clinical isolates of Staphylococcus aureus, phagocytosed by human monocytes, was investigated. Intracellular bioactivity was studied in a 24-hour assay, using experimental conditions which allowed the intracell...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238973

    authors: Fietta A,Boeri P,Colombo ML,Merlini C,Gialdroni Grassi G

    更新日期:1993-01-01 00:00:00

  • Pharmacokinetic study on adenomatous prostate tissue concentrations of cefoperazone. Clinical efficacy and patient tolerance of intramuscular cefoperazone treatment of chronic bacterial prostatitis.

    abstract::Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238704

    authors: Melloni D,Ammatuna P,Formica P,Falletta V,Gaglio F,Cacciatore M,Messina G

    更新日期:1989-01-01 00:00:00

  • Lipopolysaccharide alterations responsible for combined quinolone and beta-lactam resistance in Pseudomonas aeruginosa.

    abstract::Resistant variants of three clinical Pseudomonas aeruginosa isolates were obtained in the presence of aztreonam. The variants exhibited a four- to eightfold increase in the minimal inhibitory concentrations to beta-lactam antibiotics (except imipenem) to quinolones, such as norfloxacin and fleroxacin, chloramphenicol ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238946

    authors: Leying HJ,Büscher KH,Cullmann W,Then RL

    更新日期:1992-01-01 00:00:00

  • Adjuvant systemic chemotherapy with gemcitabine for stage IV pancreatic cancer: a preliminary report of initial experience.

    abstract:BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000088952

    authors: Kurosaki I,Hatakeyama K

    更新日期:2005-10-01 00:00:00

  • Fosfomycin-induced protoplasts and L-forms of Staphylococcus aureus.

    abstract::The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Pro...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238242

    authors: Schmid EN

    更新日期:1984-01-01 00:00:00

  • In vitro and in vivo studies of the action of rifampicin, clofazimine and B1912 on Mycobacterium marinum.

    abstract::Rifampicin (RMP) and two riminophenazine compounds (B663 and B1912) suppressed the growth of Mycobacterium marinum in vitro and in a mouse footpad infection. At appropriate concentrations and dietary dosage, all three drugs showed bactericidal activity in vitro and in vivo. On the basis of minimum inhibitory concentra...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000221931

    authors: Banerjee DK,Holmes IB

    更新日期:1976-01-01 00:00:00

  • Fluoropyrimidine-Associated Toxicity in Two Gastrointestinal Cancer Patients: Potential Role of Common DPYD Polymorphisms.

    abstract::While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) ge...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000477333

    authors: Falvella FS,Luoni M,Cheli S,Fava S,Cergnul M

    更新日期:2017-01-01 00:00:00

  • 5-Fluorouracil/leucovorin combined with irinotecan and oxaliplatin (FOLFIRINOX) as second-line chemotherapy in patients with advanced pancreatic cancer who have progressed on gemcitabine-based therapy.

    abstract:BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000356158

    authors: Lee MG,Lee SH,Lee SJ,Lee YS,Hwang JH,Ryu JK,Kim YT,Kim DU,Woo SM

    更新日期:2013-01-01 00:00:00

  • Influence of dosage interval on the therapeutic response to gentamicin in mice infected with Klebsiella pneumoniae.

    abstract::Without treatment all mice died after receiving 10(3) Klebsiella pneumoniae by intraperitoneal injection. Nevertheless, it was possible to delay treatment for 12 h and still observe a therapeutic response from im gentamicin (5 mg/kg). This gave initial serum concentrations comparable to clinical levels, which fell rap...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238477

    authors: Queiroz ML,Bathirunathan N,Mawer GE

    更新日期:1987-01-01 00:00:00

  • Variable sensitivity of lymphoblastoid cells to apoptosis induced by Viscum album Qu FrF, a therapeutic preparation of mistletoe lectin.

    abstract:BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000048545

    authors: Duong Van Huyen JP,Sooryanarayana,Delignat S,Bloch MF,Kazatchkine MD,Kaveri SV

    更新日期:2001-09-01 00:00:00

  • Antifungal prophylaxis during neutropenia or allogeneic bone marrow transplantation: what is the state of the art? Ad HOC Working Group.

    abstract::Neutropenia induced by intensive chemotherapy and allogeneic bone marrow transplantation are increasingly commonly complicated by fungal infections; thus prophylaxis may be justified. The authors surveyed the literature and culled their experience - few randomized trials have been done and definitions have often been ...

    journal_title:Chemotherapy

    pub_type: 杂志文章,评审

    doi:10.1159/000239052

    authors: Denning DW,Donnelly JP,Hellreigel KP,Ito J,Martino P,van't Wout JW

    更新日期:1992-01-01 00:00:00

  • Selection of Klebsiella pneumoniae mutants with high-level cefotaxime resistance during growth in serum containing therapeutic concentrations of cefotaxime.

    abstract:BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000048581

    authors: Bedenić B

    更新日期:2002-03-01 00:00:00

  • In vitro and in vivo antiplasmodial activity of Momordica balsamina alone or in a traditional mixture.

    abstract:BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000095960

    authors: Benoit-Vical F,Grellier P,Abdoulaye A,Moussa I,Ousmane A,Berry A,Ikhiri K,Poupat C

    更新日期:2006-01-01 00:00:00

  • Comparative randomized pilot study of azithromycin and doxycycline efficacy and tolerability in the treatment of prostate infection caused by Ureaplasma urealyticum.

    abstract::A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...

    journal_title:Chemotherapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000090234

    authors: Skerk V,Mareković I,Markovinović L,Begovac J,Skerk V,Barsić N,Majdak-Gluhinić V

    更新日期:2006-01-01 00:00:00

  • Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy.

    abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....

    journal_title:Chemotherapy

    pub_type:

    doi:10.1159/000499375

    authors: Cheng V,Rawlins M,Chang T,Fox E,Dyer J,Allen C,Litton E,Page MM,Hoad K,Roberts JA

    更新日期:2019-01-01 00:00:00

  • Comparison of in vitro antimicrobial activity of AM-1155 with those of tosufloxacin and fleroxacin against clinical isolates of Neisseria gonorrhoeae harboring quinolone resistance alterations in GyrA and ParC.

    abstract::The in vitro antimicrobial activities of AM-1155, a new fluoroquinolone, tosufloxacin and fleroxacin were tested against 55 clinical isolates of Neisseria gonorrhoeae using the agar dilution method. In our previous study, all the strains had been examined for mutations in the region corresponding to the quinolone-resi...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000239573

    authors: Deguchi T,Yasuda M,Nakano M,Ozeki S,Kanematsu E,Fukuda H,Maeda S,Saito I,Kawada Y

    更新日期:1997-07-01 00:00:00

  • Changes of surface hydrophobicity and charge of Staphylococcus aureus treated with sub-MIC of antibiotics and their effects on the chemiluminescence response of phagocytic cells.

    abstract::The effects of the sub-MIC of antibiotics on the surface hydrophobicity and charge of Staphylococcus aureus were examined by the contact angle method and by microscopic electrophoresis, and the production of oxygen-derived radicals by mouse peritoneal macrophages was measured by a luminol-chemiluminescence assay. The ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000239327

    authors: Nomura S,Kuroiwa A,Nagayama A

    更新日期:1995-03-01 00:00:00

  • Feasibility study of adjuvant chemotherapy of S-1 and carboplatin for completely resected non-small cell lung cancer.

    abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...

    journal_title:Chemotherapy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000351101

    authors: Komazaki Y,Sakashita H,Furuiye M,Fujie T,Tamaoka M,Sumi Y,Miyazaki Y,Kojima K,Jin Y,Inase N

    更新日期:2013-01-01 00:00:00

  • Antibiotic susceptibility of community hospital blood culture isolates of gram-negative bacilli.

    abstract::The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Result...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238243

    authors: Gordon RC,Tack KJ,Haddy RI,Fechner L,Wofford R

    更新日期:1984-01-01 00:00:00

  • Modulating effect of subinhibitory concentrations of compound LY 127935 on the virulence of Escherichia coli in the mouse.

    abstract::The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238068

    authors: Pusztai-Markos Z,Pranada F,Leimbrock C

    更新日期:1982-01-01 00:00:00

  • Nevirapine toxicity in non-HIV cancer patients.

    abstract:BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...

    journal_title:Chemotherapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000159273

    authors: Landriscina M,Fabiano A,Lombardi V,Santodirocco M,Piscazzi A,Fersini A,De Vis K,Barone C,Cignarelli M

    更新日期:2008-01-01 00:00:00

  • Vaginal secretion levels after 6 days, 3 days and 1 day of treatment with 100, 200 and 500 mg vaginal tablets of clotrimazole and their therapeutic efficacy.

    abstract::Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238151

    authors: Mendling W,Plempel M

    更新日期:1982-01-01 00:00:00

  • Antibacterial effects of niridazole. I. Effect on infection of mice with Salmonella typhimurium.

    abstract::Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238069

    authors: Hof H,Müller KM,Heine WD

    更新日期:1982-01-01 00:00:00

  • An analysis of therapeutic, adult antibiotic prescriptions issued by dental practitioners in Jordan.

    abstract:OBJECTIVE:The aim of this study was to determine the therapeutic adult antibiotics prescribed by dental practitioners working in the Jordan University Hospital. METHODS:Adult dental prescriptions for therapeutic antibiotics issued between 1 January 2003 and 31 May 2004 by dental specialists working in the Jordan Unive...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000112313

    authors: Dar-Odeh NS,Abu-Hammad OA,Khraisat AS,El Maaytah MA,Shehabi A

    更新日期:2008-01-01 00:00:00

  • Studies on the mode of action of 5-fluorocytosine in Aspergillus species.

    abstract::The mode of action of 5-fluorocytosine (5-FC) was studied in three isolates of pathogenic Aspergillus with varying degrees of susceptibility to the drug. Distribution studies showed that susceptibility or resistance to 5-FC was not dependent on uptake of the drug. While only a small percentage of the total 5-FC taken ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000237824

    authors: Wagner GE,Shadomy S

    更新日期:1979-01-01 00:00:00

  • Cefepime resistance and associated risk factors among Escherichia coli strains isolated from clinical specimens.

    abstract::Cefepime is active against bacteria producing chromosomally and plasmid-mediated extended broad-spectrum β-lactamase enzymes. The aim of this study was to evaluate risk factors for acquisition of cefepime resistance in Escherichia coli strains among hospitalized patients in a university hospital in Sanandaj, Iran. The...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000323623

    authors: Mansouri M,Ramazanzadeh R,Norabadi P

    更新日期:2011-01-01 00:00:00

  • 2',3'-Dideoxycytidine preferentially inhibits in vitro growth of granulocyte-macrophage colony-forming cells from patients with chronic myeloid leukemia.

    abstract::The effect of three nucleoside analogs, including 2-methyl-2'-deoxyadenosine (MDA), 5-amino-2'-deoxyuridine (ADU) and 2',3'-dideoxycytidine (DDC) on colony formation from unfractionated human bone marrow obtained from volunteers expressing parameters typical for normal cells (NBM) and from patients with the diagnosis ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238844

    authors: Cinatl J Jr,Cinatl J,Gussetis ES,Nemeth U,Mainke M,Kornhuber B,Brendel M,Doerr HW

    更新日期:1991-01-01 00:00:00

  • Pharmacokinetics and antibacterial efficacy in vivo of beta-lactam combinations against Proteus vulgaris.

    abstract::The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238136

    authors: Dalhoff A,Gehl AE,Gau W,Lode H

    更新日期:1982-01-01 00:00:00

  • Influences of cisplatin combination chemotherapy on oxygen radical generation by blood in elderly and adult patients with lung cancer.

    abstract::Oxygen radical generation by blood cells before and after chemotherapy was investigated in 16 elderly (72.8 +/- 1.0 years) and 14 adult (45.0 +/- 2.4 years) patients with lung cancer, using a lucigenin-dependent chemiluminescence method. The oxygen radical generation by 100 microliters of blood before chemotherapy in ...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000239348

    authors: Teramoto S,Fukuchi Y,Shu CY,Orimo H

    更新日期:1995-05-01 00:00:00

  • Pharmacokinetic studies of norfloxacin in laboratory animals.

    abstract::Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml afte...

    journal_title:Chemotherapy

    pub_type: 杂志文章

    doi:10.1159/000238283

    authors: Gilfillan EC,Pelak BA,Bland JA,Malatesta PF,Gadebusch HH

    更新日期:1984-01-01 00:00:00