Abstract:
:The effect of three nucleoside analogs, including 2-methyl-2'-deoxyadenosine (MDA), 5-amino-2'-deoxyuridine (ADU) and 2',3'-dideoxycytidine (DDC) on colony formation from unfractionated human bone marrow obtained from volunteers expressing parameters typical for normal cells (NBM) and from patients with the diagnosis of chronic myeloid leukemia (CMLBM) was observed. For the clonal growth of granulocyte-macrophage colony-forming cells (GM-CFC), a semisolid fibrin clot culture medium supplemented with 20% fetal bovine serum and 10% human placental conditioned medium was used. DDC has been shown to be at least a 10-fold more potent inhibitor for the growth of GM-CFC from CMLBM than from NBM. On the other hand, the effect of MDA and ADU on CMLBM did not differ markedly from the effect on NBM. These results suggest that DDC inhibits preferentially progenitor cells from CMLBM.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Cinatl J Jr,Cinatl J,Gussetis ES,Nemeth U,Mainke M,Kornhuber B,Brendel M,Doerr HWdoi
10.1159/000238844subject
Has Abstractpub_date
1991-01-01 00:00:00pages
128-33issue
2eissn
0009-3157issn
1421-9794journal_volume
37pub_type
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