Abstract:
:Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammatory reaction due to Salmonella infection. A suppressive effect of niridazole treatment on immunity to challenge infection with S. typhimurium was not found, as demonstrated by infection with a niridazole-resistant strain of S. typhimurium.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Hof H,Müller KM,Heine WDdoi
10.1159/000238069subject
Has Abstractpub_date
1982-01-01 00:00:00pages
143-52issue
2eissn
0009-3157issn
1421-9794journal_volume
28pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract:BACKGROUND:Transplant-related mortality (TRM) significantly decreases the long-term survival of patients with hematopoietic diseases who undergo hematopoietic stem cell transplantation (HSCT). METHODS:We retrospectively evaluated the risk factors for TRM of 58 consecutive patients with hematopoietic disease who underw...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000080691
更新日期:2004-10-01 00:00:00
abstract::108 white rats weighing 170-250 G were given trimethoprim, sulphamethoxazole and the combination trimethoprim 1/sulphamethoxazole orally and parenterally in order to test the preventive effect of these substances on experimental hematogenous pyelonephritis due to Staphylococcus aureus. Oral applications of 48 mg/kg/24...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221848
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:In this study, the in vitro antimicrobial activity and spectrum of new dimeric compounds derived from the cyanobacterial alkaloid nostocarboline were investigated. The mechanism of action and selectivity to bacteria were studied and compared to the cationic antiseptic chlorhexidine. METHODS:Minimal inhibito...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000320033
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The combination of transarterial chemoembolization (TACE) and apatinib has been used in the treatment of intermediate or advanced hepatocellular carcinoma (HCC). However, its effectiveness and safety are also argued. METHODS:Eligible studies were collected from a computer search of literatures published fro...
journal_title:Chemotherapy
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000502510
更新日期:2019-01-01 00:00:00
abstract::We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238927
更新日期:1991-01-01 00:00:00
abstract::The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238576
更新日期:1988-01-01 00:00:00
abstract::Lower respiratory tract infections are the major cause of death due to infectious disease in the developed and developing world. Despite substantial progress in defining pathogens and in therapeutic options, there continues to be major controversies in the clinical management of these infections. This report reviews t...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000048489
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048581
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000265128
更新日期:2009-01-01 00:00:00
abstract::Minimal bactericidal concentrations of trimethoprim, nalidixic acid, and nitrofurantoin revealed effective intraphagolysosomal bactericidal activity against several assay strains of Serratia marcescens as determined with phenylbutazone-treated (2 mg/ml) fresh defibrinated human blood (55 vol%), following killing of ex...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238125
更新日期:1982-01-01 00:00:00
abstract::On the basis of a regression analysis of the correlation between minimal inhibitory concentration (MIC) and inhibitory zone diameter, interpretative criteria are established for the agar diffusion test with ceftriaxone disks (30 micrograms) in DST agar according to the DIN method. The correlation is good (r = -0.9242)...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238245
更新日期:1984-01-01 00:00:00
abstract::A method is described which may be used to compare the relative activity of beta-lactam antibiotics against gram-negative bacilli. The method offers several important advantages over conventional methods of evaluation of the antibacterial activity of beta-lactam agents: the bacterial inoculum is simply and accurately ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221965
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000351101
更新日期:2013-01-01 00:00:00
abstract::Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238817
更新日期:1990-01-01 00:00:00
abstract::A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000064919
更新日期:2002-07-01 00:00:00
abstract::The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238068
更新日期:1982-01-01 00:00:00
abstract::In a randomized study 87 patients received perioperative antibiotic prophylaxis with 2 x 2 g ceftriaxone (Rocephin) at the beginning of the operation and in the following morning. Seventy-two patients received no antibiotic prophylaxis. In patients receiving the prophylaxis, a lower incidence of infections was observe...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238686
更新日期:1989-01-01 00:00:00
abstract::The aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract. The diffusion into pulmonary tissue and bronchial secretion and the antibacterial activity of the two antibiotics were evaluated in vivo by means of the inhibitory quotient. Ceftri...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238651
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine the antimicrobial susceptibility patterns among common pathogens in the intensive care unit (ICU) of a university hospital in Iran between 2006 and 2009. METHODS:The isolates cultured in appropriate media and antimicrobial susceptibility were determined by disk diffusio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000321032
更新日期:2010-01-01 00:00:00
abstract::Enterococcus faecalis plays an important role as a pathogen in polymicrobial infections. We evaluated the efficacy of cefozopran (CZOP) using polymicrobial pyometra rats. Rats were infected with a mixed intrauterine inoculation of E. faecalis plus either Bacteroides fragilis or Prevotella bivia (minimal inhibitory con...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007100
更新日期:1998-03-01 00:00:00
abstract::We report here the antibacterial activity of the new penem antibiotic Men 10700 against a total of 740 gram-positive and gram-negative clinical isolates, in comparison to imipenem, meropenem, cefotaxime, ceftriaxone, ciprofloxacin and gentamicin. Men 10700 has shown a wide spectrum of antibacterial activity, with a po...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007233
更新日期:1999-11-01 00:00:00
abstract::The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238097
更新日期:1982-01-01 00:00:00
abstract::Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007151
更新日期:1998-11-01 00:00:00
abstract::Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not lik...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000081992
更新日期:2005-01-01 00:00:00
abstract::In children undergoing anticancer chemotherapy, a granulocytopenic febrile episode is a life-threatening condition. Prompt initiation of empirical broad-spectrum antibiotics is essential to limit morbidity and mortality. To evaluate the cost-effectiveness of combination antibiotics consisting of a third generation cep...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239590
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000095960
更新日期:2006-01-01 00:00:00
abstract::The effect of acyclovir (ACV) treatment on selected functions of human blood-derived macrophages was examined. ACV was not cytotoxic when applied in a wide range of concentrations. Only minor effects on macrophage functions were observed when cells were treated with therapeutic concentrations of ACV:phagocytosis and t...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239126
更新日期:1993-05-01 00:00:00
abstract::The activity of aztreonam (a beta-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative pathogens, either alone or in association with other bacteria. Of a total st...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238721
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000159273
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048545
更新日期:2001-09-01 00:00:00