High teicoplanin uptake by human neutrophils.

Abstract:

:The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,700 +/- 1,300 micrograms/ml. The mechanism of drug uptake was by an active process and transported (cellular) drug retained its antimicrobial activity. Washing removed 42% of cellular drug. Teicoplanin inhibited PMN chemotaxis at very high concentrations and PMN microbicidal activity at lower concentrations.

journal_name

Chemotherapy

journal_title

Chemotherapy

authors

Maderazo EG,Breaux SP,Woronick CL,Quintiliani R,Nightingale CH

doi

10.1159/000238576

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

248-55

issue

3

eissn

0009-3157

issn

1421-9794

journal_volume

34

pub_type

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