Abstract:
:The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,700 +/- 1,300 micrograms/ml. The mechanism of drug uptake was by an active process and transported (cellular) drug retained its antimicrobial activity. Washing removed 42% of cellular drug. Teicoplanin inhibited PMN chemotaxis at very high concentrations and PMN microbicidal activity at lower concentrations.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Maderazo EG,Breaux SP,Woronick CL,Quintiliani R,Nightingale CHdoi
10.1159/000238576subject
Has Abstractpub_date
1988-01-01 00:00:00pages
248-55issue
3eissn
0009-3157issn
1421-9794journal_volume
34pub_type
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