Abstract:
:The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persistence in the peritoneal cavity of the mouse were found after intraperitoneal infection. In order to exclude the suggestion that the enhanced virulence was only due to the separation of filaments into normal virulent bacilli, the course of experimental infection with normal virulent germs was investigated under treatment with subtherapeutic doses of the antibiotic. When animals treated with repeated doses of 10-15 microgram/kg of LY 127935 were intraperitoneally infected a significantly smaller elimination rate of bacteria was observed in the peritoneal cavity than in animals injected with saline.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Pusztai-Markos Z,Pranada F,Leimbrock Cdoi
10.1159/000238068subject
Has Abstractpub_date
1982-01-01 00:00:00pages
135-42issue
2eissn
0009-3157issn
1421-9794journal_volume
28pub_type
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