Abstract:
BACKGROUND:Combination antimicrobial therapy is often necessary to eradicate infections caused by gram-negative bacteria.
METHODS:To evaluate the potential benefit of aztreonam and fluoroquinolone combination therapy, the activity of aztreonam in combination with ciprofloxacin, gatifloxacin, levofloxacin and moxifloxacin was assessed using checkerboard testing for four clinical isolates of each of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter cloacae, Burkholderia cepacia and Pseudomanas aeruginosa.
RESULTS:All aztreonam and fluoroquinolone combinations demonstrated additive activity [fractional inhibitory concentration (FIC) index >0.5-4] or synergy (FIC index journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
相关文献
CHEMOTHERAPY文献大全abstract::Twenty Pseudomonas maltophilia isolates were examined for susceptibility to beta-lactam antibiotics, including carbapenems, and for beta-lactamase production. All the isolates were resistant to imipenem (MICs 64-512 mg/l) and to a lesser extent, to meropenem (MICs 16-256 mg/l). None of the isolates produced significan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238757
更新日期:1990-01-01 00:00:00
abstract::The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222052
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000175465
更新日期:2009-01-01 00:00:00
abstract::The pharmacokinetics of miocamycin, a new macrolide antibiotic, was studied in 6 healthy controls and 6 patients with compensated liver cirrhosis. The results indicate that in chronic liver disease the kinetics of the drug is altered. Therefore, a dosage adjustment of miocamycin is recommended when dealing with these ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238690
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Ceftazidime is a third-generation cephalosporin almost entirely eliminated by glomerular filtration and dose reductions are essential in patients with renal impairment. The physicochemical and pharmacokinetic properties of ceftazidime make it susceptible to be eliminated by continuous renal replacement thera...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000100864
更新日期:2007-01-01 00:00:00
abstract::Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238706
更新日期:1989-01-01 00:00:00
abstract::Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222001
更新日期:1977-01-01 00:00:00
abstract::Our previous study demonstrated that the effects of isoniazid (INH) on Mycobacterium tuberculosis at the cellular level varied according to the growth phases. In this study, the variations in the INH action on M. avium strain NCTC 8559 are reported. M. avium cells grown on Middlebrook 7H10 agar were harvested at diffe...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000104470
更新日期:2007-01-01 00:00:00
abstract::We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amika...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007223
更新日期:1999-09-01 00:00:00
abstract::The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048498
更新日期:2001-01-01 00:00:00
abstract::In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000100013
更新日期:2007-01-01 00:00:00
abstract::Minimal bactericidal concentrations of trimethoprim, nalidixic acid, and nitrofurantoin revealed effective intraphagolysosomal bactericidal activity against several assay strains of Serratia marcescens as determined with phenylbutazone-treated (2 mg/ml) fresh defibrinated human blood (55 vol%), following killing of ex...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238125
更新日期:1982-01-01 00:00:00
abstract::The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to r...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007091
更新日期:1998-01-01 00:00:00
abstract::Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237980
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:The rise in the rates of antibiotic resistance among Pseudomonas aeruginosa strains from cystic fibrosis (CF) patients is concerning and underscores the need for the development of novel compounds. Among them CSA-13, a cationic steroid molecule, mimics the activity of naturally occurring antimicrobial peptid...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000335588
更新日期:2011-01-01 00:00:00
abstract::The effect of low concentrations of various antimicrobial agents on the adherence of mucoid Staphylococcus epidermidis to intraocular lenses was investigated. Adherent growth of S. epidermidis on to polymethylmethacrylate lenses was greatly diminished by ciprofloxacin and clindamycin (>75%), followed by ceftazidime ( ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007165
更新日期:1999-01-01 00:00:00
abstract::The pharmacokinetic disposition of 5-fluorocytosine (5-FC) was studied in 7 patients with acute renal failure undergoing continuous hemofiltration (CH). CH was performed with a high-flux membrane and the average filtration rate (FR) was 16.3 ml/min. Following an intravenous loading dose of 2,500 mg, 5-FC concentration...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238478
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000362085
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000317750
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000099985
更新日期:2007-01-01 00:00:00
abstract::Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000049159
更新日期:2001-01-01 00:00:00
abstract::The effects of the sub-MIC of antibiotics on the surface hydrophobicity and charge of Staphylococcus aureus were examined by the contact angle method and by microscopic electrophoresis, and the production of oxygen-derived radicals by mouse peritoneal macrophages was measured by a luminol-chemiluminescence assay. The ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239327
更新日期:1995-03-01 00:00:00
abstract::A single oral dose of an antimicrobial agent is as effective as a conventional 3-day course for the treatment of uncomplicated lower urinary tract infections. A case history of a young woman with recurrent cystitis is presented to demonstrate this approach to the management of a common clinical problem. The place of a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239487
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The application of liposome-encapsulated cytostatics results in higher concentrations in tumor tissue. This effect can be further increased by blood flow retardation with longer retention time in the tumor and by arterial administration realized in abdominal stop-flow therapy, a separate partial circulation ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000077805
更新日期:2004-06-01 00:00:00
abstract::After intravenous bolus injection of single doses of 25, 50, 75 and 100 mg of ofloxacin (HOE 280) to 34 healthy male volunteers, concentrations of unchanged drug were estimated at various times in serum and urine over 32 and 48 h. Ofloxacin concentrations were determined using high-pressure liquid chromatography (HPLC...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238567
更新日期:1988-01-01 00:00:00
abstract::The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to c...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000093034
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Our objectives were to assess the pharmacokinetic interaction and body fluid penetration of ciprofloxacin and levofloxacin. METHODS:This study was a single-dose open randomized three-way crossover in 15 healthy volunteers receiving 500 mg oral levofloxacin, 500 mg oral ciprofloxacin, or 250 mg levofloxacin ...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000329520
更新日期:2011-01-01 00:00:00
abstract::One patient of sepsis by P. aeruginosa after the implanting of a ventriculoatrial valve following extirpation of an expansive intracranial process is studied. During the evolution of the septic process there appeared as associated nephrotic syndrome with histologic lesions corresponding to an acute exudative glomerula...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222085
更新日期:1977-01-01 00:00:00
abstract::Hydrocortisone (HC) has been observed to influence an in vitro Dexter culture system with maintenance of pluripotent hematopoietic stem cells (CFU-s) and progenitor cells (CFU-gm, BFU-e). In the present study, a two-phase murine Dexter culture system was established to study the mechanism of HC-mediated suppression of...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238340
更新日期:1985-01-01 00:00:00
abstract::A rational choice of an antimicrobial agent must take into account not only the activity against the specific pathogen but also any possible negative or positive effects on the host defense system. Rokitamycin (RKM) is an orally active 16-membered-ring macrolide; there are no reports of specific investigations of thes...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239560
更新日期:1997-05-01 00:00:00