Correlations between thymidylate synthase expression and chemosensitivity to 5-fluorouracil, cell proliferation and clinical outcome in head and neck squamous cell carcinoma.

abstract：:Fosfomycin, an antibiotic discovered in Spain, has a unique chemical structure and pharmacologic features that are promising for clinical therapy. It is only partially absorbed orally, with relatively low blood levels. Intramuscularly, however, absorption is complete with peak blood levels 3-5 times as high as orally,...

journal_title：Chemotherapy

authors： Kirby WM

更新日期：1977-01-01 00:00:00

abstract：:Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...

journal_title：Chemotherapy

authors： Llorens J,Ley G,Forés A,Olay T

更新日期：1977-01-01 00:00:00

abstract：:The in vitro activity of fleroxacin was determined by broth microdilution against 2,079 recent bacterial isolates and compared to the activities of ciprofloxacin, ofloxacin, lomefloxacin, cefaclor, cefuroxime, cefixime, ceftriaxone, amoxicillin/clavulanate, trimethoprim/sulfamethoxazole (TMP-SMX), and, as appropriate,...

journal_title：Chemotherapy

authors： Markowitz SM,Williams DS,Hanna CB,Parker JL,Pierce MA,Steele JC Jr

更新日期：1995-11-01 00:00:00

abstract：:Lower respiratory tract infections are the major cause of death due to infectious disease in the developed and developing world. Despite substantial progress in defining pathogens and in therapeutic options, there continues to be major controversies in the clinical management of these infections. This report reviews t...

journal_title：Chemotherapy

authors： Bartlett J

更新日期：2000-01-01 00:00:00

abstract：:Our previous study demonstrated that the effects of isoniazid (INH) on Mycobacterium tuberculosis at the cellular level varied according to the growth phases. In this study, the variations in the INH action on M. avium strain NCTC 8559 are reported. M. avium cells grown on Middlebrook 7H10 agar were harvested at diffe...

journal_title：Chemotherapy

authors： Mohamad S,Ibrahim P,Wahab HA

更新日期：2007-01-01 00:00:00

abstract：:Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...

journal_title：Chemotherapy

authors： Mendling W,Plempel M

更新日期：1982-01-01 00:00:00

abstract：:Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...

journal_title：Chemotherapy

authors： Yamabe S

更新日期：1980-01-01 00:00:00

abstract：:After intravenous bolus injection of single doses of 25, 50, 75 and 100 mg of ofloxacin (HOE 280) to 34 healthy male volunteers, concentrations of unchanged drug were estimated at various times in serum and urine over 32 and 48 h. Ofloxacin concentrations were determined using high-pressure liquid chromatography (HPLC...

journal_title：Chemotherapy

authors： Verho M,Korn A,Badian M,Malerczyk V,Waldhäusl W

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis. PATIENTS AND METHODS:Neuropathy was determined through clinical and electromyographic findings during the ...

journal_title：Chemotherapy

authors： Aksoy F,Akdogan E,Aydin K,Yilmaz M,Altunayoglu V,Sozen EE,Omay SB,Koksal I

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS:Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a referenc...

journal_title：Chemotherapy

authors： Wagenlehner FM,Wagenlehner CM,Blenk B,Blenk H,Schubert S,Dalhoff A,Naber KG

更新日期：2011-01-01 00:00:00

abstract：:Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml afte...

journal_title：Chemotherapy

authors： Gilfillan EC,Pelak BA,Bland JA,Malatesta PF,Gadebusch HH

更新日期：1984-01-01 00:00:00

abstract：:The in vitro activity of the new semisynthetic ureidopenicillins azlocillin (AZ) and mezlocillin (MZ), and of the new cephalosporin cefsulodin (CEF) were determined against 50 carbenicillin-sensitive (CARs) and 50 carbenicillin-resistant (CARr) P. aeruginosa clinical isolates. In the CARs group the most active antibio...

journal_title：Chemotherapy

authors： Perea EJ,Palomares JC,García-Iglesias MC

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:The brain is a frequent site of metastases in small-cell lung cancer. Symptoms of cerebral involvement are headache, disorientation, nausea/vomiting and seizures. CASE:A man with small-cell lung cancer developed a human herpesvirus 6 (HHV-6) meningoencephalitis with neurological symptoms that simulated brai...

journal_title：Chemotherapy

authors： Mordenti P,Zaffignani E,Immovilli P,Nobili E,Cavanna L

更新日期：2013-01-01 00:00:00

abstract：:Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...

journal_title：Chemotherapy

authors： Bousquet C,Puente E,Buscail L,Vaysse N,Susini C

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is a common illness that creates significant burdens upon the healthcare system. Improving the quality of medical care for patients with this illness requires an evidence-based and cost-efficient treatment approach. The first step in this approach is to make an accurate diagnosis, wh...

journal_title：Chemotherapy

authors： Fine MJ

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...

journal_title：Chemotherapy

authors： Komazaki Y,Sakashita H,Furuiye M,Fujie T,Tamaoka M,Sumi Y,Miyazaki Y,Kojima K,Jin Y,Inase N

更新日期：2013-01-01 00:00:00

abstract：:We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amika...

journal_title：Chemotherapy

authors： Jacobson K,Rolston K,Elting L,LeBlanc B,Whimbey E,Ho DH

更新日期：1999-09-01 00:00:00

abstract：:While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) ge...

journal_title：Chemotherapy

authors： Falvella FS,Luoni M,Cheli S,Fava S,Cergnul M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The prognosis of patients with advanced gastric cancer (AGC) remains poor, and no single chemotherapy regimen is recognized as a global standard. A phase II trial was conducted to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients wi...

journal_title：Chemotherapy

authors： Luo HY,Xu RH,Wang F,Qiu MZ,Li YH,Li FH,Zhou ZW,Chen XQ

更新日期：2010-01-01 00:00:00

abstract：:Antibacterial kinetics of modified-release clarithromycin (CLA) and azithromycin (AZI) against respiratory tract pathogens were compared in relation to their pharmacokinetic profile. The study was carried out in three strains of Streptococcus pneumoniae, group A beta-hemolytic Streptococcus pyogenes, Moraxella catarrh...

journal_title：Chemotherapy

authors： Scaglione F,Demartini G,Dugnani S,Fraschini F

更新日期：2000-09-01 00:00:00

abstract：:The involvement of plasma testosterone in patients associated with scalp hair loss accelerated by anticancer drugs including aclarubicin and cisplatin was investigated. Scalp hair loss observed was minor in 12 and severe in 2 out of 31 patients. In patients without significant hair loss, the combination of aclarubicin...

journal_title：Chemotherapy

authors： Umeki S,Niki Y,Soejima R

更新日期：1989-01-01 00:00:00

abstract：:Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amika...

journal_title：Chemotherapy

authors： Hostacká A,Karelová E

更新日期：1997-03-01 00:00:00

abstract：:A total of 30 hospitalized patients with upper and lower urinary tract infections were treated with cefotaxime (HR-756) by intramuscular or intravenous route. All patients had a monomicrobial infection, and the major part of bacterial isolates were gram-negative bacilli (83%) while gram-positive cocci accounted only f...

journal_title：Chemotherapy

authors： Paradisi F,Cristiano P,Mirone V,D'Armiento V,Iovene MR

更新日期：1982-01-01 00:00:00

abstract：:The pharmacokinetic disposition of 5-fluorocytosine (5-FC) was studied in 7 patients with acute renal failure undergoing continuous hemofiltration (CH). CH was performed with a high-flux membrane and the average filtration rate (FR) was 16.3 ml/min. Following an intravenous loading dose of 2,500 mg, 5-FC concentration...

journal_title：Chemotherapy

authors： Ittel TH,Legler UF,Polak A,Glöckner WM,Sieberth HG

更新日期：1987-01-01 00:00:00

abstract：:A multicenter study aimed at assessing the in vitro activity of sulbactam/ampicillin against a wide range of bacterial pathogens was performed using 2,209 clinical strains, all recently collected from inpatients in seven Italian centers and preliminarily screened as being ampicillin-resistant and beta-lactamase produc...

journal_title：Chemotherapy

authors： Varaldo PE,Ripa S,Nicoletti G,Covelli I,Satta G,Carlone N,Fontana R

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Ceftazidime is a third-generation cephalosporin almost entirely eliminated by glomerular filtration and dose reductions are essential in patients with renal impairment. The physicochemical and pharmacokinetic properties of ceftazidime make it susceptible to be eliminated by continuous renal replacement thera...

journal_title：Chemotherapy

authors： Isla A,Gascón AR,Maynar J,Arzuaga A,Sánchez-Izquierdo JA,Pedraz JL

更新日期：2007-01-01 00:00:00

abstract：:The susceptibility of 26 strains of Campylobacter pylori to 7 new quinolone antibiotics and nalidixic acid was determined. All strains were resistant to nalidixic acid. Difloxacin, A-56620, A-62254, and ciprofloxacin were equally effective against the test strains with MICs ranging from 0.06 to 2.0 micrograms/ml. Fler...

journal_title：Chemotherapy

authors： Hupertz V,Carr H,Czinn SJ

更新日期：1988-01-01 00:00:00

abstract：:Many bis(amidinohydrazones) are potent inhibitors of adenosylmethionine decarboxylase (AdoMetDC), a key enzyme of polyamine biosynthesis, and some of them are also known to be powerful antiviral agents. Therefore, seven bis(amidinohydrazones), including the two most potent inhibitors of eukaryotic AdoMetDC so far repo...

journal_title：Chemotherapy

authors： Elo H

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...

journal_title：Chemotherapy

authors： Lee MG,Lee SH,Lee SJ,Lee YS,Hwang JH,Ryu JK,Kim YT,Kim DU,Woo SM

更新日期：2013-01-01 00:00:00