Abstract:
:Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amikacin at 4 x MIC concentration (to 10-69.2% of the control values); 2 x MIC was less effective. The profile of outer membrane proteins of P. aeruginosa was not changed after treatment with amikacin at both concentrations.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Hostacká A,Karelová Edoi
10.1159/000239545subject
Has Abstractpub_date
1997-03-01 00:00:00pages
118-22issue
2eissn
0009-3157issn
1421-9794journal_volume
43pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238470
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase. Those strains displayed varying degrees of beta-lactam resistance and a wide range of beta-lactamase a...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048581
更新日期:2002-03-01 00:00:00
abstract::Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts throug...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000049159
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatib...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000354986
更新日期:2013-01-01 00:00:00
abstract::The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238097
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000088952
更新日期:2005-10-01 00:00:00
abstract::The in vitro activities of the newer agents Deptomycin, Difloxacin, A-56620 and Ciprofloxacin were compared with those of vancomycin, rifampin and gentamicin against methicillin-susceptible and -resistant Staphylococcus aureus and coagulase-negative staphylococci. All isolates were susceptible to vancomycin, rifampin,...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238691
更新日期:1989-01-01 00:00:00
abstract::The study of resistance patterns of strains of bacteria to antibiotics in different regions of a country and, if possible, comparing them at international level appears to be a useful exercise. The patterns of resistance during 1968-71 revealed an increasing resistance for most antibiotics with an unexpected increase ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221890
更新日期:1975-01-01 00:00:00
abstract::Data from five clinical trials of amphotericin B colloidal dispersion (ABCD) in the treatment of invasive mycoses were pooled to analyze the renal sparing effects of ABCD. Serum creatinine levels at baseline and either during or at end of treatment were available for 499 of 572 patients (87.2%). The median cumulative ...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000048469
更新日期:1999-06-01 00:00:00
abstract::Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238069
更新日期:1982-01-01 00:00:00
abstract::The intraphagocytic killing of Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa, and Salmonella typhi by ciprofloxacin (0.1, 1 and 5 microg/ml) within human neutrophils with intact and impaired (by phenylbutazone treatment) O2-dependent killing mechanisms was studied and compared with the extracellular ki...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007196
更新日期:1999-07-01 00:00:00
abstract::Our previous studies demonstrated the efficacy of cationic liposome-encapsulated doxycycline (CaL-DOX) on the course of infection with Chlamydia trachomatis in vitro and in vivo. In this investigation, the pharmacokinetics of CaL-DOX are reported. Female mice inoculated intravaginally with 4.84 x 10(5) inclusion-formi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000077279
更新日期:2004-04-01 00:00:00
abstract::An in vitro infection model was created using a suspension of macrophages, polymorphonuclear leukocytes, lymphocytes, fibroblasts, and human serum to which pathogen and antibiotic were added. Separate intracellular and extracellular antibiotic concentrations and activity against Staphylococcus aureus and Legionella pn...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238987
更新日期:1993-11-01 00:00:00
abstract::We conducted a survey of susceptibility among 758 gram-negative bacilli (GNB; collected from cancer patients over a 3-month period) to commonly used antibiotics. The overall resistance among GNB was least for piperacillin/tazobactam and meropenem (5 and 6%, respectively) followed by cefepime (8%), imipenem (9%), amika...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007223
更新日期:1999-09-01 00:00:00
abstract::Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....
journal_title:Chemotherapy
pub_type:
doi:10.1159/000499375
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000475879
更新日期:2017-01-01 00:00:00
abstract::21 patients, whose age ranged from 17 to 60 years and who had not been previously treated with antibiotics or other drugs, received bacampicillin as a perioperative prophylaxis for minor operations in the oral cavity. Four oral doses of bacampicillin were administered: each dose of 800 mg every 12 h, and the last dose...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238541
更新日期:1988-01-01 00:00:00
abstract::A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000064919
更新日期:2002-07-01 00:00:00
abstract::A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000090234
更新日期:2006-01-01 00:00:00
abstract::Contrary to L-lysine, D-lysine showed no inhibitory effect on growth of Ehrlich ascites tumour cell in in vivo studies. The in vitro studies on the growth of cultured Ehrlich ascites tumour cells showed similar results, namely, the growth of tumour cells was inhibited when cultured in 0.02 or 0.03 M L-lysine; while 0....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238657
更新日期:1989-01-01 00:00:00
abstract::Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluoroura...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238212
更新日期:1983-01-01 00:00:00
abstract::Antimicrobial agents may interact with polymorphonuclear leukocytes and directly modify the leukocyte functions, or bacteria can be modified by the antimicrobial agents causing them to be treated differently by phagocytic cells. Brief exposure of bacteria to high levels of antimicrobials can affect their interaction w...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239179
更新日期:1994-03-01 00:00:00
abstract::Biliary excretion of cefaclor, a new orally active cephalosporin, was studied in vitro using an isolated rabbit liver preparation perfused for 3 h (n = 5). Under these conditions, bile recovery amounted to 2.3% of the cefaclor dose added to the circulating blood (10 mg). In humans, after oral administration of a 1-gra...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238075
更新日期:1982-01-01 00:00:00
abstract::The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238068
更新日期:1982-01-01 00:00:00
abstract::We report here the antibacterial activity of the new penem antibiotic Men 10700 against a total of 740 gram-positive and gram-negative clinical isolates, in comparison to imipenem, meropenem, cefotaxime, ceftriaxone, ciprofloxacin and gentamicin. Men 10700 has shown a wide spectrum of antibacterial activity, with a po...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007233
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000158662
更新日期:2008-01-01 00:00:00
abstract::The post-antibiotic effects (PAEs) of a new cephalosporin, cefdinir, were determined against a range of organisms using a viable counting technique. Cefdinir exerted considerable PAEs against Staphylococcus aureus and Streptococcus pyogenes, but no overall post-antibiotic inhibition of growth was detected against Esch...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239198
更新日期:1994-07-01 00:00:00
abstract::Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222069
更新日期:1977-01-01 00:00:00
abstract::Many bis(amidinohydrazones) are potent inhibitors of adenosylmethionine decarboxylase (AdoMetDC), a key enzyme of polyamine biosynthesis, and some of them are also known to be powerful antiviral agents. Therefore, seven bis(amidinohydrazones), including the two most potent inhibitors of eukaryotic AdoMetDC so far repo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238790
更新日期:1990-01-01 00:00:00
abstract::Several agar media (Mueller-Hinton agar, MHA; diagnostic sensitivity test agar, DSTA; Schaedler agar, SchA; Todd-Hewitt agar with added yeast extract, THYA; Wilkins-Chalgren agar, WCA) were compared using the Bauer-Kirby agar disk diffusion test against six nonfastidious quality control strains: Staphylococcus aureus ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239296
更新日期:1994-01-01 00:00:00