Post-antibiotic effects of cefdinir on Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus pyrogenes.

abstract：:Susceptibility of 983 isolates of Staphyloccus aureus to tetracycline, doxycycline and minocycline was determined in vitro. Minocycline was shown to be more active than doxycycline, which in turn was shown to be slightly more active than tetracycline. 77% of the isolates which were resistant to tetracycline were also ...

journal_title：Chemotherapy

authors： Lewis SA,Altemeier WA

更新日期：1976-01-01 00:00:00

abstract：:The antimicrobial resistance patterns of respiratory pathogens isolated during an 8-year period (1990-1997) in an Italian hospital from patients with bronchopulmonary infections were investigated. A global variation in the resistance of Staphylococcus aureus to all relevant antibiotics was observed during the years 19...

journal_title：Chemotherapy

authors： Dos Santos C,Capelo A,Cimbro M,Ferrara A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The prognosis of patients with advanced gastric cancer (AGC) remains poor, and no single chemotherapy regimen is recognized as a global standard. A phase II trial was conducted to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients wi...

journal_title：Chemotherapy

authors： Luo HY,Xu RH,Wang F,Qiu MZ,Li YH,Li FH,Zhou ZW,Chen XQ

更新日期：2010-01-01 00:00:00

abstract：:Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...

journal_title：Chemotherapy

authors： Hof H,Emmerling P,Seeliger HP

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...

journal_title：Chemotherapy

authors： Rotte A,Garmann D,Buss I,Jaehde U

更新日期：2010-01-01 00:00:00

abstract：:Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking....

journal_title：Chemotherapy

authors： Cheng V,Rawlins M,Chang T,Fox E,Dyer J,Allen C,Litton E,Page MM,Hoad K,Roberts JA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...

journal_title：Chemotherapy

authors： Yasumatsu R,Nakashima T,Uryu H,Ayada T,Wakasaki T,Kogo R,Masuda M,Fukushima M,Komune S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Dosage recommendations for antibiotics in patients receiving continuous veno-venous hemofiltration (CVVH) should be based on pharmacodynamic requirements. For meropenem, this would be achieving appropriate time above the minimum inhibitory concentration (T > MIC). We employed Monte Carlo simulation to calcul...

journal_title：Chemotherapy

authors： Kuti JL,Nicolau DP

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Adherence to imatinib therapy has been significantly associated with disease progression and direct medical costs in gastrointestinal stromal tumor (GIST) patients. However, adherence to oral anticancer drugs is frequently hindered by the influence of various factors. The aim of this study was to evaluate th...

journal_title：Chemotherapy

authors： Wang Y,Zhang P,Han Y,Nelson RS,McLeod HL,Tao K,Yuan Y,Zhang M,Xiang H,Zhou H

更新日期：2019-01-01 00:00:00

abstract：:The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,...

journal_title：Chemotherapy

authors： Maderazo EG,Breaux SP,Woronick CL,Quintiliani R,Nightingale CH

更新日期：1988-01-01 00:00:00

abstract：:The in vitro activity of sparfloxacin, a new fluoroquinolone, was compared with ciprofloxacin and ofloxacin against 166 consecutive isolates from the upper respiratory tract of outpatients. The strains were fully susceptible to three quinolones. The antibacterial activity of sparfloxacin was comparable or better than ...

journal_title：Chemotherapy

authors： Malmborg AS,Ahlén S

更新日期：1993-01-01 00:00:00

abstract：:Ninety-three representative, recent clinical isolates of Streptococcus pneumoniae were examined for susceptibility to 9 antimicrobial drugs utilizing Mueller-Hinton agar (MHA) enriched with sheep blood and a hypercapnic atmosphere of incubation. One isolate was resistant to penicillin G (minimum inhibitory concentrati...

journal_title：Chemotherapy

authors： Traub WH,Leonhard B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...

journal_title：Chemotherapy

authors： Shin BS,Bulitta JB,Hong DK,Kim HY,Kim MK,Choi Y,Lee JB,Hwang SW,Lee MH,Yoo SD

更新日期：2011-01-01 00:00:00

abstract：:BMY-28142 was compared in vitro with ceftazidime, cefotaxime and cefoperazone and was found to be more active against Pseudomonas aeruginosa and Staphylococcus aureus. Essentially no effect of increasing inoculum size 100-fold was seen-on MICs with BMY-28142 or ceftazidime; some effect was noted with cefotaxime and ce...

journal_title：Chemotherapy

authors： Norden CW,Neiderriter K

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality. TREATMENT:First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-l...

journal_title：Chemotherapy

authors： McLoughlin R,O'Morain C

更新日期：2005-08-01 00:00:00

abstract：:A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...

journal_title：Chemotherapy

authors： Lode H,Tomas W,Koeppe P,Wagner J

更新日期：1980-01-01 00:00:00

abstract：:Treatment of enterococcal infections is often difficult because of intrinsic and acquired resistance to a variety of antimicrobial agents. Between January 1993 and May 1997, enterococci were isolated from blood cultures of 117 patients at the Institute of Medical Microbiology and Immunology, University Hospital Eppend...

journal_title：Chemotherapy

authors： Elsner HA,Sobottka I,Feucht HH,Claussen M,Kaulfers PM,Laufs R,Mack D

更新日期：2000-03-01 00:00:00

abstract：:The involvement of plasma testosterone in patients associated with scalp hair loss accelerated by anticancer drugs including aclarubicin and cisplatin was investigated. Scalp hair loss observed was minor in 12 and severe in 2 out of 31 patients. In patients without significant hair loss, the combination of aclarubicin...

journal_title：Chemotherapy

authors： Umeki S,Niki Y,Soejima R

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Gram-negative bacilli are the most common bacteria causing nosocomial bloodstream infections (NBSIs) in Latin American countries. METHODS:The antibiotic resistance profiles of Gram-negative bacilli isolated from blood cultures in pediatric patients with NBSIs over a 3-year period in a tertiary care pediatri...

journal_title：Chemotherapy

authors： Ares MÁ,Alcántar-Curiel MD,Jiménez-Galicia C,Rios-Sarabia N,Pacheco S,De la Cruz MÁ

更新日期：2013-01-01 00:00:00

abstract：:Itraconazole has emerged as an important new oral agent in the treatment of systemic fungal infections. This paper summarizes the data available on its use in aspergillosis, cryptococcosis and histoplasmosis, compiled in the United States with particular attention to the immunocompromised host. Data have been accrued ...

journal_title：Chemotherapy

authors： Hostetler JS,Denning DW,Stevens DA

更新日期：1992-01-01 00:00:00

abstract：:One patient of sepsis by P. aeruginosa after the implanting of a ventriculoatrial valve following extirpation of an expansive intracranial process is studied. During the evolution of the septic process there appeared as associated nephrotic syndrome with histologic lesions corresponding to an acute exudative glomerula...

journal_title：Chemotherapy

authors： Rodriguéz-Gironés M,Genovés A

更新日期：1977-01-01 00:00:00

abstract：:Two gonococcal strains with differing susceptibility to cefotiam and ceftizoxime, as expressed by the minimum inhibitory concentration (MIC), are exposed to continuously changing concentrations of these antibiotics as they are found in plasma and skin cantharidal blister fluid (CBF) after a single intramuscular applic...

journal_title：Chemotherapy

authors： Korting HC,Niederauer H,Ollert M

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...

journal_title：Chemotherapy

authors： Duong Van Huyen JP,Sooryanarayana,Delignat S,Bloch MF,Kazatchkine MD,Kaveri SV

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the therapeutic adult antibiotics prescribed by dental practitioners working in the Jordan University Hospital. METHODS:Adult dental prescriptions for therapeutic antibiotics issued between 1 January 2003 and 31 May 2004 by dental specialists working in the Jordan Unive...

journal_title：Chemotherapy

authors： Dar-Odeh NS,Abu-Hammad OA,Khraisat AS,El Maaytah MA,Shehabi A

更新日期：2008-01-01 00:00:00

abstract：:A total of 5 healthy volunteers were enrolled in a crossover study on the dose dependency and the effect of probenecid on pharmacokinetics of DQ-2556. They were administered intravenously 0.5 and 1.0 g of DQ-2556, and 1.0 g of DQ-2556 with oral administration of probenecid. The linearity in pharmacokinetics of DQ-2556...

journal_title：Chemotherapy

authors： Shiba K,Yoshida M,Shimada J,Saito A,Matsubayashi K,Hashimoto S,Yoshida K,Osada Y,Sakai O

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：:The elimination of para-aminosalicylic acid (PAS) after the intravenous injection of 20 mg PAS sodium/kg was estimated in patients with liver disease, in uremic patients and in volunteers without damage of the liver or kidneys. The drug was estimated with a colorimetric and fluorometric method. In the volunteers, the ...

journal_title：Chemotherapy

authors： Held H,Fried F

更新日期：1977-01-01 00:00:00

abstract：:The intracellular activity of flurithromycin, erythromycin, roxithromycin and miocamycin against susceptible clinical isolates of Staphylococcus aureus, phagocytosed by human monocytes, was investigated. Intracellular bioactivity was studied in a 24-hour assay, using experimental conditions which allowed the intracell...

journal_title：Chemotherapy

authors： Fietta A,Boeri P,Colombo ML,Merlini C,Gialdroni Grassi G

更新日期：1993-01-01 00:00:00

abstract：:Some acridine compounds referred to as 9-imino, 9-oxo and 9-thio derivatives were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most ac...

journal_title：Chemotherapy

authors： Osuna A,Ruiz-Perez LM,Gamarro F,Rodriguez-Santiago JI,Castanys S,Sharples D,Galy AM,Giovannageli G,Galy JP,Soyfer JC

更新日期：1988-01-01 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum(II), CDDP) is one of the most important chemotherapeutic agents; however, the mechanisms of resistance to this drug are still unknown. Recent reports have demonstrated that chemotherapy can induce apoptosis in some cancer cells, indicating that apoptosis may play a very importan...

journal_title：Chemotherapy

authors： Mese H,Sasaki A,Alcalde RE,Nakayama S,Matsumura T

更新日期：2000-01-01 00:00:00