Abstract:
BACKGROUND:The brain is a frequent site of metastases in small-cell lung cancer. Symptoms of cerebral involvement are headache, disorientation, nausea/vomiting and seizures. CASE:A man with small-cell lung cancer developed a human herpesvirus 6 (HHV-6) meningoencephalitis with neurological symptoms that simulated brain involvement from the lung cancer. HHV-6 is a T cell lymphotropic virus which may be pathogenic in the immunocompromised host. HHV-6 remains latent after the first infection, and when the immune system is compromised it can reactivate. The treatment of HHV-6 infection is highly specific and the drugs recommended are the two antivirals, ganciclovir or foscarnet. CONCLUSION:In cancer patients neurologic symptoms are usually due to brain metastases. This case shows that in a cancer patient any aspecific neurologic symptom should be carefully evaluated in order to exclude a non-oncologic cause. This statement is particularly true if the therapies for the oncological and neurological diseases are effective.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Mordenti P,Zaffignani E,Immovilli P,Nobili E,Cavanna Ldoi
10.1159/000360616subject
Has Abstractpub_date
2013-01-01 00:00:00pages
385-6issue
5eissn
0009-3157issn
1421-9794pii
000360616journal_volume
59pub_type
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