Voriconazole-induced neuropathy.

abstract：BACKGROUND:Some new quinolones (NQs) modulate polymorphonuclear leukocyte (PMN) functions. We investigated these effects on PMN functions at concentrations <10 microg/ml. METHODS:Chemotactic activity and the production of reactive oxygen species (ROS) were measured using a 48-well chemotaxis chamber and by luminol-dep...

journal_title：Chemotherapy

authors： Koshio O,Ono Y

更新日期：2009-01-01 00:00:00

abstract：:Data from five clinical trials of amphotericin B colloidal dispersion (ABCD) in the treatment of invasive mycoses were pooled to analyze the renal sparing effects of ABCD. Serum creatinine levels at baseline and either during or at end of treatment were available for 499 of 572 patients (87.2%). The median cumulative ...

journal_title：Chemotherapy

authors： Gurwith M,Mamelok R,Pietrelli L,Du Mond C

更新日期：1999-06-01 00:00:00

abstract：:A multicenter study aimed at assessing the in vitro activity of sulbactam/ampicillin against a wide range of bacterial pathogens was performed using 2,209 clinical strains, all recently collected from inpatients in seven Italian centers and preliminarily screened as being ampicillin-resistant and beta-lactamase produc...

journal_title：Chemotherapy

authors： Varaldo PE,Ripa S,Nicoletti G,Covelli I,Satta G,Carlone N,Fontana R

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...

journal_title：Chemotherapy

authors： Rapoport BL,Uys A

更新日期：2008-01-01 00:00:00

abstract：:Differences in the pharmacokinetic parameters of cephalosporins between children and adults may be predictable on the basis of the level of maturation of the physiologic processes involved in drug disposition. It appears that the most important of these factors (gastrointestinal, renal and hepatic function) are reason...

journal_title：Chemotherapy

authors： Edwards DJ,Stoeckel K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...

journal_title：Chemotherapy

authors： Guiral E,Bosch J,Vila J,Soto SM

更新日期：2012-01-01 00:00:00

abstract：:Susceptibility of 983 isolates of Staphyloccus aureus to tetracycline, doxycycline and minocycline was determined in vitro. Minocycline was shown to be more active than doxycycline, which in turn was shown to be slightly more active than tetracycline. 77% of the isolates which were resistant to tetracycline were also ...

journal_title：Chemotherapy

authors： Lewis SA,Altemeier WA

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:This study assessed the population pharmacokinetics and metabolic conversion of a novel histone deacetylase (HDAC) inhibitor, SD-2007, into its active metabolite, apicidin, in rats. METHODS:SD-2007 was given to rats by intravenous injection (4 mg/kg) and oral administration (40 mg/kg). Serum concentrations ...

journal_title：Chemotherapy

authors： Shin BS,Bulitta JB,Hong DK,Kim HY,Kim MK,Choi Y,Lee JB,Hwang SW,Lee MH,Yoo SD

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Considering the potentials of gatifloxacin and moxifloxacin in the treatment of tuberculosis, the present study was aimed to define resistance to both these drugs. METHODS:Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofloxacin-susceptible and 20 ofloxacin-resistant strains, were tested for th...

journal_title：Chemotherapy

authors： Somasundaram S,Paramasivan NC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...

journal_title：Chemotherapy

authors： Várkonyi J,Szabó T,Sebestyén P,Tordai A,Andrikovics H,Kollai G,Karádi I

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...

journal_title：Chemotherapy

authors： El Malki HO,Mohsine R,Benkhraba K,Amahzoune M,Benkabbou A,El Absi M,Ifrine L,Belkouchi A,Balafrej S

更新日期：2006-01-01 00:00:00

abstract：:The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...

journal_title：Chemotherapy

authors： Borner K,Lode H,Hampel B,Pfeuffer M,Koeppe P

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...

journal_title：Chemotherapy

authors： Kim SH,Jeong SH,Kim JW,Lee SH,Kim JM

更新日期：2009-01-01 00:00:00

abstract：:The activity of aztreonam (a beta-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative pathogens, either alone or in association with other bacteria. Of a total st...

journal_title：Chemotherapy

authors： Birolini D,Moraes MF,de Souza OS

更新日期：1989-01-01 00:00:00

abstract：:A narcissus alkaloid, pretazettine hydrochloride (PTZ), has been shown to be active against Ehrlich ascites carcinoma. The Ehrlich cells are more sensitive to PTZ in DBA/2 mice than in Swiss mice. The therapeutic activity of the individual standard drugs in ABC (adriamycin, BCNU, and cyclophosphamide) regimen against ...

journal_title：Chemotherapy

authors： Furusawa E,Lum MK,Furusawa S

更新日期：1981-01-01 00:00:00

abstract：:The frustration and disappointment in managing advanced cancers of the nose and paranasal sinuses are well known. We report a case of a successful treatment of such a tumour in a 37-year-old soldier, using a combination of therapy including surgery, chemotherapy and radiation. Each mode of treatment is discussed. ...

journal_title：Chemotherapy

authors： Chandrasekaran S,Baba AA,Othman N,Jayakumar CR

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIMS:There is no standard consensus on a strategy in the second-line setting for gemcitabine-refractory advanced pancreatic cancer. This study evaluated the activity and tolerability of oxaliplatin, irinotecan, 5-fluorouracil and leucovorin (FOLFIRINOX) as a second-line therapy in advanced pancreatic adenoca...

journal_title：Chemotherapy

authors： Lee MG,Lee SH,Lee SJ,Lee YS,Hwang JH,Ryu JK,Kim YT,Kim DU,Woo SM

更新日期：2013-01-01 00:00:00

abstract：:Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...

journal_title：Chemotherapy

authors： Smith JT

更新日期：1991-01-01 00:00:00

abstract：:Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling a...

journal_title：Chemotherapy

authors： Fu KP,Grace ME,McCloud SJ,Gregory FJ,Hung PP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The glomerular filtration rate (GFR) is essential for calculating the dose and the monitoring of carboplatin. Although GFR measurement (mGFR) by external markers is ideal, in most cases these are not employed; the most used method is GFR estimation (eGFR) by formulae, hence the need to identify the formula w...

journal_title：Chemotherapy

authors： Graciano Vera N,Pino Villarreal L,Ureña Vargas J

更新日期：2018-01-01 00:00:00

abstract：:The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Pro...

journal_title：Chemotherapy

authors： Schmid EN

更新日期：1984-01-01 00:00:00

abstract：:The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The para...

journal_title：Chemotherapy

authors： Meldrum JB,Gupta VS,Babiuk LA

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...

journal_title：Chemotherapy

authors： Quan ZW,Yue JN,Li JY,Qin YY,Guo RS,Li SG

更新日期：2008-01-01 00:00:00

abstract：:Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been reported to have a hig...

journal_title：Chemotherapy

authors： Saraswathi V,Ramamoorthy N,Subramaniam S,Mathuram V,Gunasekaran P,Govindasamy S

更新日期：1998-05-01 00:00:00

abstract：:The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37 degrees C) of PMN with different concentrations of linezolid (2, 10 and 20 mg/l) did not significantly affect the phagocytosis of either...

journal_title：Chemotherapy

authors： Ballesta S,Pascual A,García I,Perea EJ

更新日期：2003-07-01 00:00:00

abstract：:The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...

journal_title：Chemotherapy

authors： Pusztai-Markos Z,Pranada F,Leimbrock C

更新日期：1982-01-01 00:00:00

abstract：:The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...

journal_title：Chemotherapy

authors： Ling TK,Liu EY,Cheng AF

更新日期：2001-01-01 00:00:00

abstract：:The activities of amphotericin B, miconazole, fluconazole, and itraconazole against Trichosporon beigelii were assessed in a mouse model of disseminated infection. Cyclophosphamide plus prednisolone-immunosuppressed ICR mice, intravenously challenged with a lethal inoculum of (6 x 10(6) CFU/ mouse), were assigned to r...

journal_title：Chemotherapy

authors： Kamberi P,Atsuro H,Takayoshi T,Masaru N

更新日期：1998-01-01 00:00:00

abstract：:A rational choice of an antimicrobial agent must take into account not only the activity against the specific pathogen but also any possible negative or positive effects on the host defense system. Rokitamycin (RKM) is an orally active 16-membered-ring macrolide; there are no reports of specific investigations of thes...

journal_title：Chemotherapy

authors： Braga PC,Maci S,Dal Sasso M,Fonti E,Ghessi A

更新日期：1997-05-01 00:00:00