Therapeutic activity of pretazettine on Ehrlich ascites carcinoma: adjuvant effect on standard drugs in ABC regimen.

abstract：:The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...

journal_title：Chemotherapy

authors： Dalhoff A,Gehl AE,Gau W,Lode H

更新日期：1982-01-01 00:00:00

abstract：:Some acridine compounds referred to as 9-imino, 9-oxo and 9-thio derivatives were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most ac...

journal_title：Chemotherapy

authors： Osuna A,Ruiz-Perez LM,Gamarro F,Rodriguez-Santiago JI,Castanys S,Sharples D,Galy AM,Giovannageli G,Galy JP,Soyfer JC

更新日期：1988-01-01 00:00:00

abstract：:Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromato...

journal_title：Chemotherapy

authors： Viitanen J,Auvinen O,Tunturi T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...

journal_title：Chemotherapy

authors： Roveta S,Marchese A,Debbia EA

更新日期：2008-01-01 00:00:00

abstract：:The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...

journal_title：Chemotherapy

authors： Casanovas X,Torralba A

更新日期：1977-01-01 00:00:00

abstract：:28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages o...

journal_title：Chemotherapy

authors： Ball AP,Brookes GR,Farrell ID,Geddes AM,Gould I

更新日期：1979-01-01 00:00:00

abstract：:Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been reported to have a hig...

journal_title：Chemotherapy

authors： Saraswathi V,Ramamoorthy N,Subramaniam S,Mathuram V,Gunasekaran P,Govindasamy S

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Patients with cancer are particularly susceptible to drug interactions (DIs), but the extent of the problem has received limited attention. We aimed to evaluate the frequency of interactions with anticancer agents in a group of cancer patients. METHODS:The study was performed in a Belgian teaching hospital....

journal_title：Chemotherapy

authors： Mouzon A,Kerger J,D'Hondt L,Spinewine A

更新日期：2013-01-01 00:00:00

abstract：:Switch therapy, or step-down therapy, is the concept of switching from an intravenous antibiotic to an oral preparation after a few days, once the condition of the patient has improved and the pathogen and its susceptibility have been determined. The orally active third-generation cephalosporin cefixime is a primary c...

journal_title：Chemotherapy

authors： Hamilton-Miller J

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis. PATIENTS AND METHODS:Neuropathy was determined through clinical and electromyographic findings during the ...

journal_title：Chemotherapy

authors： Aksoy F,Akdogan E,Aydin K,Yilmaz M,Altunayoglu V,Sozen EE,Omay SB,Koksal I

更新日期：2008-01-01 00:00:00

abstract：:A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...

journal_title：Chemotherapy

authors： Lode H,Tomas W,Koeppe P,Wagner J

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...

journal_title：Chemotherapy

authors： Jin B,Huang AM,Zhong RB,Han BH

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The effects of gemcitabine on postoperative adjuvant chemotherapy were evaluated in patients with stage IV pancreatic cancer. The results were compared with those of our historical control patients treated with surgery alone. PATIENTS AND METHODS:Nineteen patients with stage IV pancreatic cancer who had pan...

journal_title：Chemotherapy

authors： Kurosaki I,Hatakeyama K

更新日期：2005-10-01 00:00:00

abstract：:Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluoroura...

journal_title：Chemotherapy

authors： Furusawa E,Furusawa E,Sokugawa L

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...

journal_title：Chemotherapy

authors： El Malki HO,Mohsine R,Benkhraba K,Amahzoune M,Benkabbou A,El Absi M,Ifrine L,Belkouchi A,Balafrej S

更新日期：2006-01-01 00:00:00

abstract：:Ten years of controlled clinical trials supported single-dose therapy efficacy and safety in uncomplicated lower urinary tract infections (UTI). Both local and systematic factors contribute to the high UTI prevalence seen in elderly people. A controlled open randomized study was undertaken to evaluate the clinical eff...

journal_title：Chemotherapy

authors： Ferraro G,Ambrosi G,Bucci L,Palmieri R,Palmieri G

更新日期：1990-01-01 00:00:00

abstract：:Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checker-board double-dilution test or by killing kinetic studies. However, amdino...

journal_title：Chemotherapy

authors： Eng RH,Liu R,Smith SM,Johnson ES,Cherubin CE

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Development of novel strategies to kill cancer by sparing normal cells is of utmost importance. Apart from their known antimicrobial activity, only limited information has been recorded regarding the antitumor potential of biocompatible silver oxide nanoparticles (AgONPs). There is a need to evaluate the ant...

journal_title：Chemotherapy

authors： Banerjee K,Das S,Choudhury P,Ghosh S,Baral R,Choudhuri SK

更新日期：2017-01-01 00:00:00

abstract：:The pharmacokinetics of miocamycin, a new macrolide antibiotic, was studied in 6 healthy controls and 6 patients with compensated liver cirrhosis. The results indicate that in chronic liver disease the kinetics of the drug is altered. Therefore, a dosage adjustment of miocamycin is recommended when dealing with these ...

journal_title：Chemotherapy

authors： Miglioli PA,Pivetta P,Orlando R,Palatini P,Varotto A,Okolicsanyi L

更新日期：1989-01-01 00:00:00

abstract：:The aminoglycoside antibiotics are polycationic at physiological pH and hence do not enter most cells. Indeed, when intact mast cells were incubated with gentamicin or tobramycin, extremely low concentrations of the two drugs could be measured. In contrast, when a controlled, specific degranulation of mast cells was i...

journal_title：Chemotherapy

authors： Decorti G,Candussio L,Klugmann FB,Baldini L

更新日期：1997-01-01 00:00:00

abstract：:Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...

journal_title：Chemotherapy

authors： Draenert FG,Draenert K

更新日期：2008-01-01 00:00:00

abstract：:The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted i...

journal_title：Chemotherapy

authors： Mally MB,Taylor RC,Callewaert DM

更新日期：1980-01-01 00:00:00

abstract：:The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37 degrees C) of PMN with different concentrations of linezolid (2, 10 and 20 mg/l) did not significantly affect the phagocytosis of either...

journal_title：Chemotherapy

authors： Ballesta S,Pascual A,García I,Perea EJ

更新日期：2003-07-01 00:00:00

abstract：:Differences in the pharmacokinetic parameters of cephalosporins between children and adults may be predictable on the basis of the level of maturation of the physiologic processes involved in drug disposition. It appears that the most important of these factors (gastrointestinal, renal and hepatic function) are reason...

journal_title：Chemotherapy

authors： Edwards DJ,Stoeckel K

更新日期：1992-01-01 00:00:00

abstract：:A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...

journal_title：Chemotherapy

authors： Kissling M,Bergamini N

更新日期：1981-01-01 00:00:00

abstract：:The 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. The compound shows antiviral activity in vitro against measles, NDV, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia vir...

journal_title：Chemotherapy

authors： Verini MA,Fioretti A,Casazza AM,Sanfilippo A,Palamidessi G,Ghione M

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...

journal_title：Chemotherapy

authors： Yasumatsu R,Nakashima T,Uryu H,Ayada T,Wakasaki T,Kogo R,Masuda M,Fukushima M,Komune S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...

journal_title：Chemotherapy

authors： Quan ZW,Yue JN,Li JY,Qin YY,Guo RS,Li SG

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...

journal_title：Chemotherapy

authors： Luo DQ,Liu JY,Yang W,Zhang B,Yu MJ,Wu YM

更新日期：2011-01-01 00:00:00

abstract：:Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1984-01-01 00:00:00