Abstract:
:Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checker-board double-dilution test or by killing kinetic studies. However, amdinocillin did show additive killing action when combined with the other beta-lactam antibiotics studied. Amdinocillin failed to induce or inhibit beta-lactamase production in species of Enterobacteriaceae, but with Pseudomonas aeruginosa, beta-lactamase production was induced. It is concluded that the activity of amdinocillin alone or in combination with another beta-lactam antibiotic should not be more effective in the treatment of infections by gram-negative bacilli than just using the beta-lactam antibiotic alone at a higher dose.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Eng RH,Liu R,Smith SM,Johnson ES,Cherubin CEdoi
10.1159/000238542subject
Has Abstractpub_date
1988-01-01 00:00:00pages
18-26issue
1eissn
0009-3157issn
1421-9794journal_volume
34pub_type
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