Abstract:
:Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum beta-D-glucan is useful for early diagnosis. Therapy with fluconazole (FLCZ) was effective in 9 of 11 patients (81.8%) suspected of having fungemia. Fungemia responded in 5 of 7 patients who were given granulocyte-colony-stimulating factor (G-CSF) concomitantly with FLCZ. This result suggested that administration of G-CSF with FLCZ was useful therapy for fungemia, which may occur during granulocytopenia following chemotherapy with anticancer agents.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Niitsu N,Umeda Mdoi
10.1159/000239445subject
Has Abstractpub_date
1996-05-01 00:00:00pages
215-19issue
3eissn
0009-3157issn
1421-9794journal_volume
42pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract::The in vitro susceptibilities of 703 clinical isolates of Salmonella to ciprofloxacin (CIP) and pefloxacin (PEF) were compared with those to trimethoprim-sulfamethoxazole (TMP-SMZ), chloramphenicol (CO) and ampicillin (AP). All isolates were susceptible to CIP, while PEF inhibited 90.7% of the strains. In contrast, re...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238745
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. METHODS:The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. RESULTS:TE...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000323629
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Viscum album (VA) Qu FrF preparation consists of an aqueous extract of Viscum album, the European mistletoe. It has cytotoxic and immunomodulatory properties that support its usefulness in cancer therapy. However, only little information is available on the interaction between mistletoe lectin (ML) and the h...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048545
更新日期:2001-09-01 00:00:00
abstract::The pharmacokinetics of ceftriaxone (CRO) after subcutaneous and intravenous administration was studied in 10 healthy volunteers (5 males, 5 females, age 22-43 years, body weight 64.3 +/- 9.5 kg). Each of them received 2.0 g CRO i.v., and then 0.5 g i.v. and 0.5 g CRO s.c. in a randomized cross-over design. Subcutaneo...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000238342
更新日期:1985-01-01 00:00:00
abstract::Many bis(amidinohydrazones) are potent inhibitors of adenosylmethionine decarboxylase (AdoMetDC), a key enzyme of polyamine biosynthesis, and some of them are also known to be powerful antiviral agents. Therefore, seven bis(amidinohydrazones), including the two most potent inhibitors of eukaryotic AdoMetDC so far repo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238790
更新日期:1990-01-01 00:00:00
abstract::New fluoroquinolones, as exemplified by levofloxacin, possess broad spectrum activity against many common pathogens, including the majority responsible for respiratory tract infections (RTIs), atypical pathogens and those resistant to other therapeutic regimens. Following administration, levofloxacin attains high intr...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000079818
更新日期:2004-01-01 00:00:00
abstract::Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238151
更新日期:1982-01-01 00:00:00
abstract::A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that hav...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221879
更新日期:1975-01-01 00:00:00
abstract::The microbiological properties of cephapirin, a new semisynthetis cephalosporin, have been studied. This antibiotic, if compared with ampicillin, shows a greater activity against gram positive bacteria, a lack of sensitivity to staphlococcal beta-lactamase, and a lower sensitivity to those produced by gram-negative ba...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221871
更新日期:1975-01-01 00:00:00
abstract::Reference is made to the results obtained in 24 children, from 11 months to 12 years, affected with acute pneumopathies and treated with fosfomycin with a dosage of 200 mg/kg/day. In all cases a clinical, radiological, biological and bacteriological study was carried out. At the same time, levels of fosfomycin in plas...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222069
更新日期:1977-01-01 00:00:00
abstract::Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000153315
更新日期:2008-01-01 00:00:00
abstract::The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238136
更新日期:1982-01-01 00:00:00
abstract::The effect of low concentrations of various antimicrobial agents on the adherence of mucoid Staphylococcus epidermidis to intraocular lenses was investigated. Adherent growth of S. epidermidis on to polymethylmethacrylate lenses was greatly diminished by ciprofloxacin and clindamycin (>75%), followed by ceftazidime ( ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007165
更新日期:1999-01-01 00:00:00
abstract::100 febrile patients with chemotherapy-induced neutropenia (less than 0.5 x 10(9)/l) were empirically treated by ceftriaxone (2 g daily in adults, 50 mg/kg daily in children, as a once daily injection) and amikacin (15-20 mg/kg daily). The mean age was 41 years (range 8-72). 51 patients had acute leukemia, 29 non-Hodg...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238883
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Combination antimicrobial therapy is often necessary to eradicate infections caused by gram-negative bacteria. METHODS:To evaluate the potential benefit of aztreonam and fluoroquinolone combination therapy, the activity of aztreonam in combination with ciprofloxacin, gatifloxacin, levofloxacin and moxifloxa...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000069786
更新日期:2003-05-01 00:00:00
abstract::Cefpirome and six other antimicrobial agents were tested against 884 blood culture isolates from cancer patients. Cefpirome was highly active against aerobic gram-negative bacilli including Acinetobacter spp., and the Enterobacteriaceae. Only imipenem was more active than cefpirome against Pseudomonas aeruginosa. Cefp...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238433
更新日期:1986-01-01 00:00:00
abstract::We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract, approximately 70% of which were diagnos...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238927
更新日期:1991-01-01 00:00:00
abstract::The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222052
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-on...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000337062
更新日期:2012-01-01 00:00:00
abstract::Current treatment modalities for bronchopulmonary aspergillosis are not very satisfying. We determined the in vitro activity of recently available azoles against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. Subsequently, these agents were evaluated in an animal model of bronchopulmonary aspergillos...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238951
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:It was the aim of this study to report clinical characteristics and treatment of thyroid tuberculosis (TT). METHODS:During 16 years, 2,426 patients have been operated on the thyroid in the surgical department 'A' in Ibn Sina Hospital, Rabat, Morocco. Anatomopathological results of the removed thyroid were an...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000090244
更新日期:2006-01-01 00:00:00
abstract::Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence of resistance because of high stool levels that are not lik...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000081992
更新日期:2005-01-01 00:00:00
abstract::The mode of action of 5-fluorocytosine (5-FC) was studied in three isolates of pathogenic Aspergillus with varying degrees of susceptibility to the drug. Distribution studies showed that susceptibility or resistance to 5-FC was not dependent on uptake of the drug. While only a small percentage of the total 5-FC taken ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237824
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000159273
更新日期:2008-01-01 00:00:00
abstract::A modified Rieckmann test was developed for assessing chloroquine sensitivity of Plasmodium vivax strains. This test envisages the evaluation of parasite growth with different concentrations of the drug and its comparison with controls, at the end of a 48-hour experimental period. Using this test, 16 strains were asse...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238664
更新日期:1989-01-01 00:00:00
abstract::Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239370
更新日期:1995-09-01 00:00:00
abstract::The pharmacokinetics of flomoxef in serum and in the mucosal tissue of the middle ear and mastoid were studied in 9 patients undergoing tympanoplasties. All patients received 1 g of flomoxef intravenously. Flomoxef levels in serum and in mucosal tissue were determined by a bioassay method. The peak value of mean conce...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238766
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:This phase II study was conducted to evaluate the efficacy and safety of the chemotherapy combination of gemcitabine and vinorelbine in taxane-pretreated Japanese metastatic breast cancer patients. METHODS:In this multicenter, phase II, single-arm study, patients with recurrent or metastatic HER2-negative b...
journal_title:Chemotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000475879
更新日期:2017-01-01 00:00:00
abstract::Aggressive non-Hodgkin lymphoma is associated with poor long-term survival after relapse or resistance to chemotherapy. We report a case of aggressive non-Hodgkin lymphoma refractory to first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and second-line R-DHAP (rituximab, dexameth...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000458147
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Our objectives were to assess the pharmacokinetic interaction and body fluid penetration of ciprofloxacin and levofloxacin. METHODS:This study was a single-dose open randomized three-way crossover in 15 healthy volunteers receiving 500 mg oral levofloxacin, 500 mg oral ciprofloxacin, or 250 mg levofloxacin ...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000329520
更新日期:2011-01-01 00:00:00