Abstract:
:The pharmacokinetics of flomoxef in serum and in the mucosal tissue of the middle ear and mastoid were studied in 9 patients undergoing tympanoplasties. All patients received 1 g of flomoxef intravenously. Flomoxef levels in serum and in mucosal tissue were determined by a bioassay method. The peak value of mean concentrations of flomoxef in the mucosal tissue was 30.3 +/- 11.7 micrograms/ml at 10 min after the administrations. Pharmacokinetic analyses showed that the concentration of flomoxef in the mucosal tissue was over 1.56 micrograms/ml (which is the MIC90 for the common pathogens of otitis media) for more than 2 h and decreased parallel with serum concentration with a half-life of about 40 min.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Saito H,Kimura T,Takeda T,Kishimoto S,Oguma T,Shimamura Kdoi
10.1159/000238766subject
Has Abstractpub_date
1990-01-01 00:00:00pages
193-9issue
3eissn
0009-3157issn
1421-9794journal_volume
36pub_type
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