Abstract:
:A technique for inducing pneumococcal meningitis in mice and a description of the histopathologic changes that accompany this experimentally produced disease are provided in the present report. This infection of mice was investigated to determine whether it could serve as a suitable model for detecting agents that have potential therapeutic utility in bacterial meningitis in man. 21 antibiotics, belonging to six major classes were evaluated for efficacy in the experimental infection. The three most active agents proved to be amoxicillin, cephaloridine, and chlortetracycline. Up to this time, amoxicillin has not been commercially available as an injectable dosage form. However, in view of the compound's outstanding efficacy in the present experiments, it would be desirable to investigate its effectiveness in the naturally occurring disease in man.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Tsai YH,Williams EB,Hirth RS,Price KEdoi
10.1159/000221879subject
Has Abstractpub_date
1975-01-01 00:00:00pages
342-57issue
6eissn
0009-3157issn
1421-9794journal_volume
21pub_type
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