Studies on the antitumour effects of N-137.

abstract：:Minimal bactericidal concentrations of trimethoprim, nalidixic acid, and nitrofurantoin revealed effective intraphagolysosomal bactericidal activity against several assay strains of Serratia marcescens as determined with phenylbutazone-treated (2 mg/ml) fresh defibrinated human blood (55 vol%), following killing of ex...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1982-01-01 00:00:00

abstract：:We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determin...

journal_title：Chemotherapy

authors： Matsuura A,Nagayama T,Kitagawa T

更新日期：1988-01-01 00:00:00

abstract：:Silver sulfadiazine was found to be devoid of mutagenic potential in a sensitive mutagenicity assay using Salmonella typhimurium. In view of the close relationship between mutagenicity in this system and carcinogenicity in animals, these findings suggest that silver sulfadiazine is apparently also devoid of carcinogen...

journal_title：Chemotherapy

authors： McCoy EC,Rosenkranz HS

更新日期：1978-01-01 00:00:00

abstract：:28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages o...

journal_title：Chemotherapy

authors： Ball AP,Brookes GR,Farrell ID,Geddes AM,Gould I

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...

journal_title：Chemotherapy

authors： Kim SH,Jeong SH,Kim JW,Lee SH,Kim JM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the feasibility and compliance of adjuvant chemotherapy of S-1 plus carboplatin for patients with completely resected non-small cell lung cancer (NSCLC) of pathological stage IB-IIIB. METHODS:S-1 was given orally at a dose of 80 mg/m²/day for 2 weeks, followed by a ...

journal_title：Chemotherapy

authors： Komazaki Y,Sakashita H,Furuiye M,Fujie T,Tamaoka M,Sumi Y,Miyazaki Y,Kojima K,Jin Y,Inase N

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients th...

journal_title：Chemotherapy

authors： Frielink LM,Pijlman BM,Ezendam NP,Pijnenborg JM

更新日期：2016-01-01 00:00:00

abstract：:Fleroxacin, a new long-acting quinolone, induces rapid killing and bacterial filamentation as do other quinolones. Ten strains of Escherichia coli were exposed comparatively to fleroxacin and ampicillin in order to determine the effect of sub- and supra-inhibitory concentrations of each of these two compounds on turbi...

journal_title：Chemotherapy

authors： Yourassowsky E,Van der Linden MP,Crokaert F

更新日期：1989-01-01 00:00:00

abstract：:The influence of orally administered fosfomycin on intestinal disaccharidases in albino rats was studied. The enzymes were evaluated in a homogenate of the intestinal mucosa, using the method of SOLS and DE LA FUENTE which is based on the colored reaction of the glucose that is freed by the disaccharidases from disacc...

journal_title：Chemotherapy

authors： Casanovas X,Torralba A

更新日期：1977-01-01 00:00:00

abstract：AIMS:This study aimed to evaluate the different abilities of various Phellinus igniarius strains inhibiting quorum sensing (QS), to search for novel QS inhibitors from them and to analyze their inhibitory activity, with a view to their possible use in controlling infections. METHODS:The bioactive metabolites produced ...

journal_title：Chemotherapy

authors： Zhu H,Liu W,Wang SX,Tian BZ,Zhang SS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Kaposi's sarcoma (KS) is the most common neoplastic apoptosis manifestation of acquired immunodeficiency syndrome. Toremifene is known to upregulate transforming growth factor beta-1 (TGF-beta1), which is a growth-inhibitory factor for KS. We investigated the in vitro effect of toremifene on KS cells. METHO...

journal_title：Chemotherapy

authors： Hong A,Leigh BR

更新日期：2002-12-01 00:00:00

abstract：:Minimal bactericidal concentrations of thienamycin revealed moderate intraphagolysosomal bactericidal activity against pseudo-(PSR) and genuinely serum-resistant (NSS) assay strains of Serratia marcescens. Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blo...

journal_title：Chemotherapy

authors： Traub WH

更新日期：1983-01-01 00:00:00

abstract：:The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...

journal_title：Chemotherapy

authors： Dalhoff A,Gehl AE,Gau W,Lode H

更新日期：1982-01-01 00:00:00

abstract：:Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...

journal_title：Chemotherapy

authors： Saijo Y,Nakai Y,Saito J,Sugawara S,Suzuki S,Numata Y,Motomiya M

更新日期：1992-01-01 00:00:00

abstract：:The efficacy of ofloxacin for the treatment of lower respiratory tract infection was evaluated in aged patients with chronic lung disease. Results are the following: improvement of leukocytosis and arterial oxygen tension was observed; peripheral blood cell analysis showed a decrease in natural killer cell counts and ...

journal_title：Chemotherapy

authors： Yamaoka M,Fukuchi Y,Yokouchi M,Teramoto N,Nagase T,Ishida K,Ohtomo E,Orimo H

更新日期：1991-01-01 00:00:00

abstract：:Recent findings justify the opinion that Chlamydia psittaci is the reappearance of a forgotten pathogen. The clinical manifestation and the course of psittacosis are extremely variable, whereas the clinical spectrum of the infection with the different strains of C. psittaci is not known. Reactive arthritis during the ...

journal_title：Chemotherapy

authors： Tsapas G,Klonizakis I,Casakos K,Koncouris L

更新日期：1991-01-01 00:00:00

abstract：:A method is described which may be used to compare the relative activity of beta-lactam antibiotics against gram-negative bacilli. The method offers several important advantages over conventional methods of evaluation of the antibacterial activity of beta-lactam agents: the bacterial inoculum is simply and accurately ...

journal_title：Chemotherapy

authors： Greenwood D

更新日期：1977-01-01 00:00:00

abstract：:The in vitro antimicrobial activities of AM-1155, a new fluoroquinolone, tosufloxacin and fleroxacin were tested against 55 clinical isolates of Neisseria gonorrhoeae using the agar dilution method. In our previous study, all the strains had been examined for mutations in the region corresponding to the quinolone-resi...

journal_title：Chemotherapy

authors： Deguchi T,Yasuda M,Nakano M,Ozeki S,Kanematsu E,Fukuda H,Maeda S,Saito I,Kawada Y

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...

journal_title：Chemotherapy

authors： Roveta S,Marchese A,Debbia EA

更新日期：2008-01-01 00:00:00

abstract：:The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The para...

journal_title：Chemotherapy

authors： Meldrum JB,Gupta VS,Babiuk LA

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:In an ongoing project to evaluate essential oils as modulators of antibiotic resistance, the essential oil from Origanum vulgare L. (OVEO), as well as its individual constituents carvacrol (CAR) and thymol (THY), were investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance...

journal_title：Chemotherapy

authors： Cirino IC,Menezes-Silva SM,Silva HT,de Souza EL,Siqueira-Júnior JP

更新日期：2014-01-01 00:00:00

abstract：:Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...

journal_title：Chemotherapy

authors： Ullmann U

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...

journal_title：Chemotherapy

authors： Spreer A,von Ruden C,Mitchell TJ,Eiffert H,Nau R

更新日期：2007-01-01 00:00:00

abstract：:On the basis of a regression analysis of the correlation between minimal inhibitory concentration (MIC) and inhibitory zone diameter, interpretative criteria are established for the agar diffusion test with ceftriaxone disks (30 micrograms) in DST agar according to the DIN method. The correlation is good (r = -0.9242)...

journal_title：Chemotherapy

authors： Grimm H

更新日期：1984-01-01 00:00:00

abstract：:The aminoglycoside antibiotics are polycationic at physiological pH and hence do not enter most cells. Indeed, when intact mast cells were incubated with gentamicin or tobramycin, extremely low concentrations of the two drugs could be measured. In contrast, when a controlled, specific degranulation of mast cells was i...

journal_title：Chemotherapy

authors： Decorti G,Candussio L,Klugmann FB,Baldini L

更新日期：1997-01-01 00:00:00

abstract：:Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...

journal_title：Chemotherapy

authors： Hof H,Müller KM,Heine WD

更新日期：1982-01-01 00:00:00

abstract：:Chronic bone and soft tissue suppurations have become more frequent recently due to the increasing number of high-energy injuries. There are certain antibiotic beads available for local administration, but they cannot always be applied specifically against the pyogenic microorganisms. In the present study, a new techn...

journal_title：Chemotherapy

authors： Börzsei L,Mintál T,Koós Z,Kocsis B,Helyes Z,Kereskai L,Nyárády J

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:To define the maximum tolerated dose (MTD) tolerability and efficacy of intra-arterial chemotherapy with irinotecan in patients with liver metastases of colorectal carcinoma (CRC). METHODS:Superselective intra-arterial irinotecan was applied on days 1, 14, 28 and 42. The initial dose was 140 mg/m² with esca...

journal_title：Chemotherapy

authors： Eichler K,Dufas T,Hammerstingl R,Gruber-Rouh T,Vogl TJ,Zangos S

更新日期：2013-01-01 00:00:00

abstract：:20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...

journal_title：Chemotherapy

authors： Franson TR,Edwards LD,Collins RF,Root TE

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...

journal_title：Chemotherapy

authors： Ozbek B,Otuk G

更新日期：2009-01-01 00:00:00