Abstract:
BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients that received adjuvant chemotherapy was determined as well as the comprehensiveness of staging and outcome. RESULTS:Forty percent (54/135) of the patients with early-stage EOC received adjuvant chemotherapy. Treatment with adjuvant chemotherapy was associated with FIGO stage, clear-cell histology and nonoptimal staging. Optimal staging was achieved in 50%, and nonoptimal staging was associated with advanced age, comorbidity and treatment in a non-referral hospital. Overall, there was no difference in outcome between patients with and without adjuvant chemotherapy. Yet, in grade 3 tumors, adjuvant chemotherapy seems beneficial. CONCLUSIONS:Selective treatment of patients with early-stage EOC might reduce adjuvant chemotherapy without compromising outcome.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Frielink LM,Pijlman BM,Ezendam NP,Pijnenborg JMdoi
10.1159/000445024subject
Has Abstractpub_date
2016-01-01 00:00:00pages
287-94issue
6eissn
0009-3157issn
1421-9794pii
000445024journal_volume
61pub_type
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