Abstract:
:AM-1155 is a new 8-methoxyquinolonecarboxylic acid with a broad spectrum of antibacterial activity. It inhibited more than 90% of clinical isolates of Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis and Prevotella bivia at the concentration of 3.13 mg/l. The antibacterial activity of AM-1155 was almost equal to that of sparfloxacin. The in vivo efficacy of AM-1155 was evaluated using a polymicrobial pyometra (E. coli and B. fragilis) model of rats. The accumulation of neutrophils to the uterus in the AM-1155-treated group was less marked than that of the nontreated group, as well as the bacteriological response. These results suggest that the new antimicrobial agent AM-1155 might be useful for the treatment of polymicrobial infections in the fields of obstetrics and gynecology.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Mikamo H,Kawazoe K,Sato Y,Hayasaki Y,Izumi K,Tamaya Tdoi
10.1159/000007120subject
Has Abstractpub_date
1998-07-01 00:00:00pages
238-42issue
4eissn
0009-3157issn
1421-9794pii
che44238journal_volume
44pub_type
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