Abstract:
:20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and the median tobramycin MIC/MBC was 6.25/25.0 micrograms/ml for all organisms studied. Median cefazolin doses of 49.0 mg/kg/day gave median peak/trough serum levels of 43.0/11.0 micrograms/ml. Median tobramycin doses of 4.3 mg/kg/day gave median peak/trough serum levels of 5.0/1.4 micrograms/ml. Checkerboard studies revealed synergy with 65% of strains. Bacteriologic and clinical success was obtained in 17 of 20 patients.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Franson TR,Edwards LD,Collins RF,Root TEdoi
10.1159/000237931subject
Has Abstractpub_date
1980-01-01 00:00:00pages
384-96issue
5eissn
0009-3157issn
1421-9794journal_volume
26pub_type
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