Abstract:
:The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resistance of the free-living ciliates against tinidazole, probably due to their aerobic condition, has been found. Nonetheless, tinidazole at high doses (1--3 mg/ml) caused severe alterations in 3 of the 4 aerobic ciliate species here studied.
journal_name
Chemotherapyjournal_title
Chemotherapyauthors
Alonso Pdoi
10.1159/000237820subject
Has Abstractpub_date
1979-01-01 00:00:00pages
40-7issue
1eissn
0009-3157issn
1421-9794journal_volume
25pub_type
杂志文章相关文献
CHEMOTHERAPY文献大全abstract:BACKGROUND:Adjuvant platinum-based chemotherapy improves survival in women with early-stage epithelial ovarian cancer (EOC). Yet, there is a wide variety in clinical practice. METHODS:All patients diagnosed with FIGO I and IIa EOC (2006-2010) in the south of the Netherlands were analyzed. The percentage of patients th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000445024
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and tolerability of hepatic arterial infusion (HAI) of gemcitabine plus oxaliplatin as second-line treatment for unresectable locally advanced intrahepatic cholangiocarcinoma. PATIENTS AND METHODS:We retrospectively analyzed the outcome of 12 consecutive pa...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000362223
更新日期:2013-01-01 00:00:00
abstract::Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally. Most unusually transferable...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000238899
更新日期:1991-01-01 00:00:00
abstract::Within recent years, novel serological and molecular methods have been developed to improve the early diagnosis of invasive fungal infections especially in patients with malignant hematological diseases being at highest risk of developing these life-threatening infections. Early diagnosis is essential for adequate the...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000007283
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate the impact of different temperatures (22, 35 and 37 degrees C) on the postantifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 x MIC) on Candida albicans and Candida glabrata in PAFE stage (PAFSE). METHODS:This stage was induced by a 1.5-hour ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000007296
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:There are only limited data on tissue kinetics of ertapenem in colorectal tissue more than 3 h after administration of the drug. The purpose of this study was to assess the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. PATIENTS AND METHODS:Patients ≥18 years requiring s...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000333377
更新日期:2011-01-01 00:00:00
abstract::The choice of antimicrobial therapy for the treatment of bacteremia is often empirical and based on the knowledge of susceptibility profiles of the most common bacteria. We analyzed blood culture isolates from a teaching hospital for 13 years prospectively. This study examined the susceptibility profiles of 6,616 gram...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048498
更新日期:2001-01-01 00:00:00
abstract::Without treatment all mice died after receiving 10(3) Klebsiella pneumoniae by intraperitoneal injection. Nevertheless, it was possible to delay treatment for 12 h and still observe a therapeutic response from im gentamicin (5 mg/kg). This gave initial serum concentrations comparable to clinical levels, which fell rap...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238477
更新日期:1987-01-01 00:00:00
abstract::Ninety-three representative, recent clinical isolates of Streptococcus pneumoniae were examined for susceptibility to 9 antimicrobial drugs utilizing Mueller-Hinton agar (MHA) enriched with sheep blood and a hypercapnic atmosphere of incubation. One isolate was resistant to penicillin G (minimum inhibitory concentrati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239450
更新日期:1996-07-01 00:00:00
abstract::Our previous study demonstrated that the effects of isoniazid (INH) on Mycobacterium tuberculosis at the cellular level varied according to the growth phases. In this study, the variations in the INH action on M. avium strain NCTC 8559 are reported. M. avium cells grown on Middlebrook 7H10 agar were harvested at diffe...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000104470
更新日期:2007-01-01 00:00:00
abstract::17,244 pathogens isolated from clinical specimens of 24 hospitals in the Moers area (North-Rhine Westphalia, FRG) were tested in regard to their susceptibility to Augmentin (amoxicillin and clavulanic acid). For this purpose, minimal inhibitory concentrations were determined by use of microbroth dilution technique. 80...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238588
更新日期:1988-01-01 00:00:00
abstract::Susceptibility of 983 isolates of Staphyloccus aureus to tetracycline, doxycycline and minocycline was determined in vitro. Minocycline was shown to be more active than doxycycline, which in turn was shown to be slightly more active than tetracycline. 77% of the isolates which were resistant to tetracycline were also ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000221939
更新日期:1976-01-01 00:00:00
abstract::The aminoglycoside antibiotics are polycationic at physiological pH and hence do not enter most cells. Indeed, when intact mast cells were incubated with gentamicin or tobramycin, extremely low concentrations of the two drugs could be measured. In contrast, when a controlled, specific degranulation of mast cells was i...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239533
更新日期:1997-01-01 00:00:00
abstract::A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. Oxihumate inhibited HIV-1 infection of MT-2 cells with an IC(50) of 12.5 microg/ml. Treatment of free and cell-attached HIV with oxihumate irreversibly reduc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000064919
更新日期:2002-07-01 00:00:00
abstract::After intravenous bolus injection of single doses of 25, 50, 75 and 100 mg of ofloxacin (HOE 280) to 34 healthy male volunteers, concentrations of unchanged drug were estimated at various times in serum and urine over 32 and 48 h. Ofloxacin concentrations were determined using high-pressure liquid chromatography (HPLC...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238567
更新日期:1988-01-01 00:00:00
abstract::Data from five clinical trials of amphotericin B colloidal dispersion (ABCD) in the treatment of invasive mycoses were pooled to analyze the renal sparing effects of ABCD. Serum creatinine levels at baseline and either during or at end of treatment were available for 499 of 572 patients (87.2%). The median cumulative ...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000048469
更新日期:1999-06-01 00:00:00
abstract::Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237903
更新日期:1980-01-01 00:00:00
abstract::Serial serum erythropoietin (EPO) levels were measured in 12 adult lung cancer patients during cancer chemotherapy. In major cases, EPO levels increased significantly after chemotherapy while the hemoglobin (Hb) remained at initial levels. EPO fell gradually or rapidly to initial levels after a peak, although the pati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000239014
更新日期:1992-01-01 00:00:00
abstract::While the majority of patients can be treated safely with fluoropyrimidine, some experience severe fluoropyrimidine-associated toxicity. The frequency and severity of these adverse events vary from patient to patient and are partially explained by genetic polymorphism into the dihydropyrimidine dehydrogenase (DPYD) ge...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000477333
更新日期:2017-01-01 00:00:00
abstract::Cephalosporins do not reach active therapeutical concentrations in the prostatic tissue in patients suffering from chronic bacterial prostatitis. Cefoperazone is an exception. Its efficacy in the treatment of chronic bacterial prostatitis in 20 patients was studied and the concentrations, obtained after intramuscular ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238704
更新日期:1989-01-01 00:00:00
abstract::The in vitro activities of quinupristin/dalfopristin (Synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. The minimal inhibitory concentrations (MICs) for quinupristin/dalfopristin against Staphyloco...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000048530
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000194974
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Taxanes cause hypersensitivity reactions, averted by premedication with H1 blockers and high glucocorticoid (GC) doses. Prolonged weekly taxane administration may lead to GC toxicity. PURPOSE:To determine whether patients not hypersensitive to initial paclitaxel (PTX) infusion after high-dose GC premedicati...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000085618
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS:The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatib...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000354986
更新日期:2013-01-01 00:00:00
abstract::20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237931
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000317750
更新日期:2010-01-01 00:00:00
abstract::We established a method for determining the KD value as a measure of the bilirubin-displacing effect for drugs by using bilirubin oxidase, which is produced by Myrothecium verrucaria MT-1. This method makes it possible to conduct measurements of many beta-lactam antibiotics, including those which could not be determin...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238590
更新日期:1988-01-01 00:00:00
abstract::A-56619 and A-56620 are two new quinolone compounds that are currently being studied. They were found to be active against multi-resistant and routine isolates of Staphylococcus aureus, enterobacteria, aminoglycoside-sensitive and resistant strains of Pseudomonas aeruginosa. Most of the enterobacteria were inhibited b...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238573
更新日期:1988-01-01 00:00:00
abstract::Despite extensive research efforts, effective therapies for refractive cancers have not yet been established, and development of successful treatment strategies remains the most important task in the field of oncology. We recently showed that AVE8062 (formerly AC7700), a derivative of combretastatin A-4, achieved irre...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000088961
更新日期:2005-10-01 00:00:00
abstract::The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus. Subminimal inhibitory concentrations of CZX inhibited the growth of bacteria. Normal human serum as a source of complement and low doses of CZX, such as 1/20...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238399
更新日期:1986-01-01 00:00:00